Gorlin syndrome-derived induced pluripotent stem cells are hypersensitive to hedgehog-mediated osteogenic induction.

Gorlin syndrome-derived induced pluripotent stem cells are hypersensitive to hedgehog-mediated osteogenic induction.

Gorlin syndrome is an autosomal dominant inherited syndrome that predisposes a patient to the formation of basal cell carcinomas, odontogenic keratocysts, and skeletal anomalies. Causative mutations in several genes associated with the sonic hedgehog (SHH) signaling pathway, including PTCH1, have be...

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Main Authors: Daigo Hasegawa, Hiromi Ochiai-Shino, Shoko Onodera, Takashi Nakamura, Akiko Saito, Takeshi Onda, Katsuhito Watanabe, Ken Nishimura, Manami Ohtaka, Mahito Nakanishi, Kenjiro Kosaki, Akira Yamaguchi, Takahiko Shibahara, Toshifumi Azuma
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5663396?pdf=render

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