Interventional Microbubble Enhanced Sonothrombolysis on Left Ventricular Assist Devices
Abstract The left ventricular assist device (LVAD) is often used in the treatment of heart failure. However, 4% to 9% implanted LVAD will have thrombosis problem in one year, which is fatal to the patient's life. In this work, an interventional sonothrombolysis (IST) method is developed to real...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-07-01
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| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202201291 |
| _version_ | 1818043591865401344 |
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| author | Xiaobing Zheng Yunfan Pan Yuan Zhang Kuilin Meng Jianye Zhou Xin Wang Yongchun Cui Jiang Li Yongjian Li Haosheng Chen |
| author_facet | Xiaobing Zheng Yunfan Pan Yuan Zhang Kuilin Meng Jianye Zhou Xin Wang Yongchun Cui Jiang Li Yongjian Li Haosheng Chen |
| author_sort | Xiaobing Zheng |
| collection | DOAJ |
| description | Abstract The left ventricular assist device (LVAD) is often used in the treatment of heart failure. However, 4% to 9% implanted LVAD will have thrombosis problem in one year, which is fatal to the patient's life. In this work, an interventional sonothrombolysis (IST) method is developed to realize the thrombolysis on LVAD. A pair of ultrasound transducer rings is installed on the shell of LVAD, and drug‐loaded microbubbles are injected into the LVAD through the interventional method. The microbubbles are adhere on the thrombus with the coated thrombus‐targeted drugs, and the thrombolytic drugs carried by the bubbles are brought into the thrombus by the cavitation of bubbles under the ultrasound. In a proof‐of‐concept experiment in a live sheep model, the thrombus on LVAD is dissolved in 30 min, without damages on LVADs and organs. This IST exhibits to be more efficient and safer compared with other thrombolysis methods on LVAD. |
| first_indexed | 2024-12-10T09:04:39Z |
| format | Article |
| id | doaj.art-de584a322c214eca94e4413552209e65 |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-12-10T09:04:39Z |
| publishDate | 2022-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-de584a322c214eca94e4413552209e652022-12-22T01:55:10ZengWileyAdvanced Science2198-38442022-07-01921n/an/a10.1002/advs.202201291Interventional Microbubble Enhanced Sonothrombolysis on Left Ventricular Assist DevicesXiaobing Zheng0Yunfan Pan1Yuan Zhang2Kuilin Meng3Jianye Zhou4Xin Wang5Yongchun Cui6Jiang Li7Yongjian Li8Haosheng Chen9State Key Laboratory of Tribology Department of Mechanical Engineering Tsinghua University Beijing 100084 ChinaState Key Laboratory of Tribology Department of Mechanical Engineering Tsinghua University Beijing 100084 ChinaSchool of Mechanical Engineering University of Science and Technology Beijing Beijing 100083 ChinaState Key Laboratory of Tribology Department of Mechanical Engineering Tsinghua University Beijing 100084 ChinaAnimal Experiment Center Fuwai Hospital Chinese Academy of Medical Sciences Beijing 100037 ChinaAnimal Experiment Center Fuwai Hospital Chinese Academy of Medical Sciences Beijing 100037 ChinaAnimal Experiment Center Fuwai Hospital Chinese Academy of Medical Sciences Beijing 100037 ChinaSchool of Mechanical Engineering University of Science and Technology Beijing Beijing 100083 ChinaState Key Laboratory of Tribology Department of Mechanical Engineering Tsinghua University Beijing 100084 ChinaState Key Laboratory of Tribology Department of Mechanical Engineering Tsinghua University Beijing 100084 ChinaAbstract The left ventricular assist device (LVAD) is often used in the treatment of heart failure. However, 4% to 9% implanted LVAD will have thrombosis problem in one year, which is fatal to the patient's life. In this work, an interventional sonothrombolysis (IST) method is developed to realize the thrombolysis on LVAD. A pair of ultrasound transducer rings is installed on the shell of LVAD, and drug‐loaded microbubbles are injected into the LVAD through the interventional method. The microbubbles are adhere on the thrombus with the coated thrombus‐targeted drugs, and the thrombolytic drugs carried by the bubbles are brought into the thrombus by the cavitation of bubbles under the ultrasound. In a proof‐of‐concept experiment in a live sheep model, the thrombus on LVAD is dissolved in 30 min, without damages on LVADs and organs. This IST exhibits to be more efficient and safer compared with other thrombolysis methods on LVAD.https://doi.org/10.1002/advs.202201291interventional therapyLVADmicrobubblethrombolysisultrasound |
| spellingShingle | Xiaobing Zheng Yunfan Pan Yuan Zhang Kuilin Meng Jianye Zhou Xin Wang Yongchun Cui Jiang Li Yongjian Li Haosheng Chen Interventional Microbubble Enhanced Sonothrombolysis on Left Ventricular Assist Devices Advanced Science interventional therapy LVAD microbubble thrombolysis ultrasound |
| title | Interventional Microbubble Enhanced Sonothrombolysis on Left Ventricular Assist Devices |
| title_full | Interventional Microbubble Enhanced Sonothrombolysis on Left Ventricular Assist Devices |
| title_fullStr | Interventional Microbubble Enhanced Sonothrombolysis on Left Ventricular Assist Devices |
| title_full_unstemmed | Interventional Microbubble Enhanced Sonothrombolysis on Left Ventricular Assist Devices |
| title_short | Interventional Microbubble Enhanced Sonothrombolysis on Left Ventricular Assist Devices |
| title_sort | interventional microbubble enhanced sonothrombolysis on left ventricular assist devices |
| topic | interventional therapy LVAD microbubble thrombolysis ultrasound |
| url | https://doi.org/10.1002/advs.202201291 |
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