The Short- and Long-Term Risk of Mortality in Intracranial Hemorrhage Patients with Tranexamic Acid Treatment in a Population-Based Cohort Study
<b>Background:</b> The mortality rate associated with nontraumatic intracranial hemorrhage (NTICrH) remains consistently high under the current care modality. The effectiveness of tranexamic acid (TXA) as a treatment option is still a subject of debate. This study aims to assess the asso...
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MDPI AG
2024-03-01
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author | Chien-Ming Chiu Sung-Yuan Hu Pei-Lun Liao Jing-Yang Huang Ming-Chih Chou Shun-Fa Yang Chao-Bin Yeh |
author_facet | Chien-Ming Chiu Sung-Yuan Hu Pei-Lun Liao Jing-Yang Huang Ming-Chih Chou Shun-Fa Yang Chao-Bin Yeh |
author_sort | Chien-Ming Chiu |
collection | DOAJ |
description | <b>Background:</b> The mortality rate associated with nontraumatic intracranial hemorrhage (NTICrH) remains consistently high under the current care modality. The effectiveness of tranexamic acid (TXA) as a treatment option is still a subject of debate. This study aims to assess the association between TXA administration and both short-term and long-term mortality rates in patients with NTICrH. <b>Methods:</b> We conducted a retrospective cohort study using data from the Taiwan National Health Insurance Research Database (NHIRD) spanning from January 2000 to December 2017. The study population consists of NTICrH patients admitted to the ICU, divided into two groups: patients who were treated with TXA and those who were not. Propensity score matching (PSM) was conducted to balance the baseline characteristics of the two groups. Cox proportional hazard analysis was conducted to estimate the hazard ratio (HR) for the all-cause mortality. Sensitivity analyses were performed using the inverse probability of treatment-weighted hazard ratio (IPTW-HR). To assess the timing of TXA use, we compared the risk of all-cause mortality within 180 days between patients receiving early TXA treatment and those receiving late TXA treatment. <b>Results:</b> There was no significant difference in 180-day all-cause mortality between the groups; the hazard ratio was 1.07 (95% CI: 0.96–1.20) in patients treated with TXA compared to those without TXA treatment. Within 7 days of admission, patients treated with TXA had a lower hazard ratio of 0.81 (95% CI: 0.74–0.90) for all-cause mortality. <b>Conclusions:</b> Lower mortality within the first 7 days was observed in patients with NTICrH who received TXA. |
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spelling | doaj.art-de58fe3dfcc646acb74d8bdcf8d0e24c2024-03-27T13:47:48ZengMDPI AGJournal of Clinical Medicine2077-03832024-03-01136159710.3390/jcm13061597The Short- and Long-Term Risk of Mortality in Intracranial Hemorrhage Patients with Tranexamic Acid Treatment in a Population-Based Cohort StudyChien-Ming Chiu0Sung-Yuan Hu1Pei-Lun Liao2Jing-Yang Huang3Ming-Chih Chou4Shun-Fa Yang5Chao-Bin Yeh6Institute of Medicine, Chung Shan Medical University, Taichung 402, TaiwanInstitute of Medicine, Chung Shan Medical University, Taichung 402, TaiwanInstitute of Medicine, Chung Shan Medical University, Taichung 402, TaiwanInstitute of Medicine, Chung Shan Medical University, Taichung 402, TaiwanInstitute of Medicine, Chung Shan Medical University, Taichung 402, TaiwanInstitute of Medicine, Chung Shan Medical University, Taichung 402, TaiwanInstitute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan<b>Background:</b> The mortality rate associated with nontraumatic intracranial hemorrhage (NTICrH) remains consistently high under the current care modality. The effectiveness of tranexamic acid (TXA) as a treatment option is still a subject of debate. This study aims to assess the association between TXA administration and both short-term and long-term mortality rates in patients with NTICrH. <b>Methods:</b> We conducted a retrospective cohort study using data from the Taiwan National Health Insurance Research Database (NHIRD) spanning from January 2000 to December 2017. The study population consists of NTICrH patients admitted to the ICU, divided into two groups: patients who were treated with TXA and those who were not. Propensity score matching (PSM) was conducted to balance the baseline characteristics of the two groups. Cox proportional hazard analysis was conducted to estimate the hazard ratio (HR) for the all-cause mortality. Sensitivity analyses were performed using the inverse probability of treatment-weighted hazard ratio (IPTW-HR). To assess the timing of TXA use, we compared the risk of all-cause mortality within 180 days between patients receiving early TXA treatment and those receiving late TXA treatment. <b>Results:</b> There was no significant difference in 180-day all-cause mortality between the groups; the hazard ratio was 1.07 (95% CI: 0.96–1.20) in patients treated with TXA compared to those without TXA treatment. Within 7 days of admission, patients treated with TXA had a lower hazard ratio of 0.81 (95% CI: 0.74–0.90) for all-cause mortality. <b>Conclusions:</b> Lower mortality within the first 7 days was observed in patients with NTICrH who received TXA.https://www.mdpi.com/2077-0383/13/6/1597tranexamic acidintracranial hemorrhagemortalitythromboembolic eventscohort study |
spellingShingle | Chien-Ming Chiu Sung-Yuan Hu Pei-Lun Liao Jing-Yang Huang Ming-Chih Chou Shun-Fa Yang Chao-Bin Yeh The Short- and Long-Term Risk of Mortality in Intracranial Hemorrhage Patients with Tranexamic Acid Treatment in a Population-Based Cohort Study Journal of Clinical Medicine tranexamic acid intracranial hemorrhage mortality thromboembolic events cohort study |
title | The Short- and Long-Term Risk of Mortality in Intracranial Hemorrhage Patients with Tranexamic Acid Treatment in a Population-Based Cohort Study |
title_full | The Short- and Long-Term Risk of Mortality in Intracranial Hemorrhage Patients with Tranexamic Acid Treatment in a Population-Based Cohort Study |
title_fullStr | The Short- and Long-Term Risk of Mortality in Intracranial Hemorrhage Patients with Tranexamic Acid Treatment in a Population-Based Cohort Study |
title_full_unstemmed | The Short- and Long-Term Risk of Mortality in Intracranial Hemorrhage Patients with Tranexamic Acid Treatment in a Population-Based Cohort Study |
title_short | The Short- and Long-Term Risk of Mortality in Intracranial Hemorrhage Patients with Tranexamic Acid Treatment in a Population-Based Cohort Study |
title_sort | short and long term risk of mortality in intracranial hemorrhage patients with tranexamic acid treatment in a population based cohort study |
topic | tranexamic acid intracranial hemorrhage mortality thromboembolic events cohort study |
url | https://www.mdpi.com/2077-0383/13/6/1597 |
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