The gut microbiota, environmental factors, and links to the development of food allergy
Abstract Food allergy appears to have its roots in an insufficient exposure to a diverse range of environmental microbiota during early life. Microbial exposure ensures the colonization of the gastrointestinal tract with commensal microbes, which is necessary for the induction of a balanced and tole...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2020-04-01
|
| Series: | Clinical and Molecular Allergy |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12948-020-00120-x |
| _version_ | 1819047583318802432 |
|---|---|
| author | Khui Hung Lee Yong Song Weidong Wu Kan Yu Guicheng Zhang |
| author_facet | Khui Hung Lee Yong Song Weidong Wu Kan Yu Guicheng Zhang |
| author_sort | Khui Hung Lee |
| collection | DOAJ |
| description | Abstract Food allergy appears to have its roots in an insufficient exposure to a diverse range of environmental microbiota during early life. Microbial exposure ensures the colonization of the gastrointestinal tract with commensal microbes, which is necessary for the induction of a balanced and tolerogenic immune function. High-throughput sequencing technology has facilitated in-depth studies of the gut microbiota as well as bacterial-derived metabolites. Although the role of the microbiota in allergies is now widely studied, its importance for food allergy was only recently noted. Studies in human cohorts have shown that there is an association of dysbiosis and pathogenesis of food allergy, while studies from animal models have demonstrated the capacity of specific species in the gut microbiota to alter immune response, which may lead to the desensitization of food allergy. This article reviews the role of the gut microbiota in food allergy, and discusses the influence of environmental factors as well as prevention and management strategies relating to such regulatory mechanism. |
| first_indexed | 2024-12-21T11:02:40Z |
| format | Article |
| id | doaj.art-de5ae2812ea5493287dc0739ba3dc637 |
| institution | Directory Open Access Journal |
| issn | 1476-7961 |
| language | English |
| last_indexed | 2024-12-21T11:02:40Z |
| publishDate | 2020-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Clinical and Molecular Allergy |
| spelling | doaj.art-de5ae2812ea5493287dc0739ba3dc6372022-12-21T19:06:18ZengBMCClinical and Molecular Allergy1476-79612020-04-0118111110.1186/s12948-020-00120-xThe gut microbiota, environmental factors, and links to the development of food allergyKhui Hung Lee0Yong Song1Weidong Wu2Kan Yu3Guicheng Zhang4School of Public Health, Curtin University of TechnologySchool of Public Health, Curtin University of TechnologySchool of Public Health, Xinxiang Medical UniversitySchool of Science, Edith Cowan UniversitySchool of Public Health, Curtin University of TechnologyAbstract Food allergy appears to have its roots in an insufficient exposure to a diverse range of environmental microbiota during early life. Microbial exposure ensures the colonization of the gastrointestinal tract with commensal microbes, which is necessary for the induction of a balanced and tolerogenic immune function. High-throughput sequencing technology has facilitated in-depth studies of the gut microbiota as well as bacterial-derived metabolites. Although the role of the microbiota in allergies is now widely studied, its importance for food allergy was only recently noted. Studies in human cohorts have shown that there is an association of dysbiosis and pathogenesis of food allergy, while studies from animal models have demonstrated the capacity of specific species in the gut microbiota to alter immune response, which may lead to the desensitization of food allergy. This article reviews the role of the gut microbiota in food allergy, and discusses the influence of environmental factors as well as prevention and management strategies relating to such regulatory mechanism.http://link.springer.com/article/10.1186/s12948-020-00120-xEnvironmental factorsFood allergyImmune systemMicrobiotaProbiotics |
| spellingShingle | Khui Hung Lee Yong Song Weidong Wu Kan Yu Guicheng Zhang The gut microbiota, environmental factors, and links to the development of food allergy Clinical and Molecular Allergy Environmental factors Food allergy Immune system Microbiota Probiotics |
| title | The gut microbiota, environmental factors, and links to the development of food allergy |
| title_full | The gut microbiota, environmental factors, and links to the development of food allergy |
| title_fullStr | The gut microbiota, environmental factors, and links to the development of food allergy |
| title_full_unstemmed | The gut microbiota, environmental factors, and links to the development of food allergy |
| title_short | The gut microbiota, environmental factors, and links to the development of food allergy |
| title_sort | gut microbiota environmental factors and links to the development of food allergy |
| topic | Environmental factors Food allergy Immune system Microbiota Probiotics |
| url | http://link.springer.com/article/10.1186/s12948-020-00120-x |
| work_keys_str_mv | AT khuihunglee thegutmicrobiotaenvironmentalfactorsandlinkstothedevelopmentoffoodallergy AT yongsong thegutmicrobiotaenvironmentalfactorsandlinkstothedevelopmentoffoodallergy AT weidongwu thegutmicrobiotaenvironmentalfactorsandlinkstothedevelopmentoffoodallergy AT kanyu thegutmicrobiotaenvironmentalfactorsandlinkstothedevelopmentoffoodallergy AT guichengzhang thegutmicrobiotaenvironmentalfactorsandlinkstothedevelopmentoffoodallergy AT khuihunglee gutmicrobiotaenvironmentalfactorsandlinkstothedevelopmentoffoodallergy AT yongsong gutmicrobiotaenvironmentalfactorsandlinkstothedevelopmentoffoodallergy AT weidongwu gutmicrobiotaenvironmentalfactorsandlinkstothedevelopmentoffoodallergy AT kanyu gutmicrobiotaenvironmentalfactorsandlinkstothedevelopmentoffoodallergy AT guichengzhang gutmicrobiotaenvironmentalfactorsandlinkstothedevelopmentoffoodallergy |