Cool executive functions and their association with body mass & fatness and the FTO gene in school-aged children
Abstract The FTO gene rs9936909 polymorphism is one of the well-documented single nucleotide polymorphisms in the context of increased risk of obesity, including in children. Few studies have tested the association of the FTO gene with cognitive functions. Deficits of “cool” executive functions (EFs...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-07-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-38808-0 |
| _version_ | 1797769604773183488 |
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| author | Paula Szcześniewska Ewa Bryl Agata Dutkiewicz Aneta R. Borkowska Karolina Bilska Elżbieta Paszyńska Agnieszka Słopień Monika Dmitrzak-Węglarz Tomasz Hanć |
| author_facet | Paula Szcześniewska Ewa Bryl Agata Dutkiewicz Aneta R. Borkowska Karolina Bilska Elżbieta Paszyńska Agnieszka Słopień Monika Dmitrzak-Węglarz Tomasz Hanć |
| author_sort | Paula Szcześniewska |
| collection | DOAJ |
| description | Abstract The FTO gene rs9936909 polymorphism is one of the well-documented single nucleotide polymorphisms in the context of increased risk of obesity, including in children. Few studies have tested the association of the FTO gene with cognitive functions. Deficits of “cool” executive functions (EFs) are considered a potential risk factor for excessive weight. The aims of our study were to investigate whether cool EFs are associated with the Body Mass Index, the Fat Mass Index and the risk of excess body mass and overfatness in neurotypically school-aged children, and whether the FTO gene polymorphism is involved in development of this possible association. The sample consisted of 553 children aged 6–12 years old. A body composition analysis, a neuropsychological assessment of EFs, and FTO polymorphism genotyping were performed in the children studied. The study found a significant association of an interference effect in theStroop Color-Word Interference Task and the risk of excessive body fatness, but not excessive body mass. There were no explicit associations between the FTO genotype and EFs deficits. Environmental factors, and particularly low maternal education, appeared to be the strongest contributors to the increased risk of obesity. |
| first_indexed | 2024-03-12T21:11:25Z |
| format | Article |
| id | doaj.art-de5b2843deb145dc88cba947f0c74818 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-12T21:11:25Z |
| publishDate | 2023-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-de5b2843deb145dc88cba947f0c748182023-07-30T11:11:35ZengNature PortfolioScientific Reports2045-23222023-07-0113111010.1038/s41598-023-38808-0Cool executive functions and their association with body mass & fatness and the FTO gene in school-aged childrenPaula Szcześniewska0Ewa Bryl1Agata Dutkiewicz2Aneta R. Borkowska3Karolina Bilska4Elżbieta Paszyńska5Agnieszka Słopień6Monika Dmitrzak-Węglarz7Tomasz Hanć8Institute of Biology and Human Evolution, Faculty of Biology, Adam Mickiewicz UniversityInstitute of Biology and Human Evolution, Faculty of Biology, Adam Mickiewicz UniversityDepartment of Child and Adolescent Psychiatry, Poznan University of Medical SciencesFaculty of Education and Psychology, Maria Curie-Sklodowska UniversityDepartment of Psychiatric Genetics, Department of Psychiatry, Poznan University of Medical SciencesDepartment of Integrated Dentistry, Poznan University of Medical SciencesDepartment of Child and Adolescent Psychiatry, Poznan University of Medical SciencesDepartment of Psychiatric Genetics, Department of Psychiatry, Poznan University of Medical SciencesInstitute of Biology and Human Evolution, Faculty of Biology, Adam Mickiewicz UniversityAbstract The FTO gene rs9936909 polymorphism is one of the well-documented single nucleotide polymorphisms in the context of increased risk of obesity, including in children. Few studies have tested the association of the FTO gene with cognitive functions. Deficits of “cool” executive functions (EFs) are considered a potential risk factor for excessive weight. The aims of our study were to investigate whether cool EFs are associated with the Body Mass Index, the Fat Mass Index and the risk of excess body mass and overfatness in neurotypically school-aged children, and whether the FTO gene polymorphism is involved in development of this possible association. The sample consisted of 553 children aged 6–12 years old. A body composition analysis, a neuropsychological assessment of EFs, and FTO polymorphism genotyping were performed in the children studied. The study found a significant association of an interference effect in theStroop Color-Word Interference Task and the risk of excessive body fatness, but not excessive body mass. There were no explicit associations between the FTO genotype and EFs deficits. Environmental factors, and particularly low maternal education, appeared to be the strongest contributors to the increased risk of obesity.https://doi.org/10.1038/s41598-023-38808-0 |
| spellingShingle | Paula Szcześniewska Ewa Bryl Agata Dutkiewicz Aneta R. Borkowska Karolina Bilska Elżbieta Paszyńska Agnieszka Słopień Monika Dmitrzak-Węglarz Tomasz Hanć Cool executive functions and their association with body mass & fatness and the FTO gene in school-aged children Scientific Reports |
| title | Cool executive functions and their association with body mass & fatness and the FTO gene in school-aged children |
| title_full | Cool executive functions and their association with body mass & fatness and the FTO gene in school-aged children |
| title_fullStr | Cool executive functions and their association with body mass & fatness and the FTO gene in school-aged children |
| title_full_unstemmed | Cool executive functions and their association with body mass & fatness and the FTO gene in school-aged children |
| title_short | Cool executive functions and their association with body mass & fatness and the FTO gene in school-aged children |
| title_sort | cool executive functions and their association with body mass fatness and the fto gene in school aged children |
| url | https://doi.org/10.1038/s41598-023-38808-0 |
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