Visual acuity and contrast sensitivity outcomes in Indian eyes undergoing photodynamic therapy with intravitreal injection of triamcinolone acetonide in age-related macular degeneration
<b>Purpose: </b> To evaluate photodynamic therapy (PDT) with verteporfin along with intravitreal triamcinolone acetonide (IVTA) in the treatment of neovascular age-related macular degeneration (AMD). <b> Materials and Methods: </b> This prospective interventional case series...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2007-01-01
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| Series: | Indian Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.ijo.in/article.asp?issn=0301-4738;year=2007;volume=55;issue=3;spage=207;epage=211;aulast=Kumar |
| _version_ | 1811323971815079936 |
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| author | Kumar Atul Sinha Subijay Kumar Vikram |
| author_facet | Kumar Atul Sinha Subijay Kumar Vikram |
| author_sort | Kumar Atul |
| collection | DOAJ |
| description | <b>Purpose: </b> To evaluate photodynamic therapy (PDT) with verteporfin along with intravitreal triamcinolone acetonide (IVTA) in the treatment of neovascular age-related macular degeneration (AMD). <b> Materials and Methods: </b> This prospective interventional case series included 23 patients (23 eyes) of choroidal neovascularization due to neovascular AMD who were treated with PDT with verteporfin followed by an injection of 4 mg IVTA. The main outcome measures were visual acuity (VA), contrast sensitivity, retreatment frequency with PDT (and triamcinolone) and frequency of side-effects. <b> Results: </b> Twenty-three eyes underwent PDT with verteporfin followed by IVTA one week later. All patients were followed up for one year. Initial VA ranged from 20/32 to 20/800 and final VA ranged from 20/40 to 20/500 at the end of 12 months. VA stabilized (that is loss/gain < 2 lines) in 19 (82%) eyes. Contrast sensitivity also improved in 16/23 eyes (70%). Lesion type and patient′s age had no influence on the outcome, but baseline VA had a borderline statistically significant effect (<i> P</i> =0.059). Six eyes (27%) had an increase in intraocular pressure that required therapy. There were no cases of endophthalmitis, but four eyes (18%) developed significant cataract that required surgery during the follow-up period. <b> Conclusion</b> : The combination of PDT along with IVTA improves contrast sensitivity and stabilizes vision during one-year follow-up. |
| first_indexed | 2024-04-13T14:04:49Z |
| format | Article |
| id | doaj.art-de5ce7b2098a4131ab3e114b04374155 |
| institution | Directory Open Access Journal |
| issn | 0301-4738 |
| language | English |
| last_indexed | 2024-04-13T14:04:49Z |
| publishDate | 2007-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Ophthalmology |
| spelling | doaj.art-de5ce7b2098a4131ab3e114b043741552022-12-22T02:43:56ZengWolters Kluwer Medknow PublicationsIndian Journal of Ophthalmology0301-47382007-01-01553207211Visual acuity and contrast sensitivity outcomes in Indian eyes undergoing photodynamic therapy with intravitreal injection of triamcinolone acetonide in age-related macular degenerationKumar AtulSinha SubijayKumar Vikram<b>Purpose: </b> To evaluate photodynamic therapy (PDT) with verteporfin along with intravitreal triamcinolone acetonide (IVTA) in the treatment of neovascular age-related macular degeneration (AMD). <b> Materials and Methods: </b> This prospective interventional case series included 23 patients (23 eyes) of choroidal neovascularization due to neovascular AMD who were treated with PDT with verteporfin followed by an injection of 4 mg IVTA. The main outcome measures were visual acuity (VA), contrast sensitivity, retreatment frequency with PDT (and triamcinolone) and frequency of side-effects. <b> Results: </b> Twenty-three eyes underwent PDT with verteporfin followed by IVTA one week later. All patients were followed up for one year. Initial VA ranged from 20/32 to 20/800 and final VA ranged from 20/40 to 20/500 at the end of 12 months. VA stabilized (that is loss/gain < 2 lines) in 19 (82%) eyes. Contrast sensitivity also improved in 16/23 eyes (70%). Lesion type and patient′s age had no influence on the outcome, but baseline VA had a borderline statistically significant effect (<i> P</i> =0.059). Six eyes (27%) had an increase in intraocular pressure that required therapy. There were no cases of endophthalmitis, but four eyes (18%) developed significant cataract that required surgery during the follow-up period. <b> Conclusion</b> : The combination of PDT along with IVTA improves contrast sensitivity and stabilizes vision during one-year follow-up.http://www.ijo.in/article.asp?issn=0301-4738;year=2007;volume=55;issue=3;spage=207;epage=211;aulast=KumarAge-related macular degenerationchoroidal neovascularizationintravitreal triamcinolonephotodynamic therapyverteporfin. |
| spellingShingle | Kumar Atul Sinha Subijay Kumar Vikram Visual acuity and contrast sensitivity outcomes in Indian eyes undergoing photodynamic therapy with intravitreal injection of triamcinolone acetonide in age-related macular degeneration Indian Journal of Ophthalmology Age-related macular degeneration choroidal neovascularization intravitreal triamcinolone photodynamic therapy verteporfin. |
| title | Visual acuity and contrast sensitivity outcomes in Indian eyes undergoing photodynamic therapy with intravitreal injection of triamcinolone acetonide in age-related macular degeneration |
| title_full | Visual acuity and contrast sensitivity outcomes in Indian eyes undergoing photodynamic therapy with intravitreal injection of triamcinolone acetonide in age-related macular degeneration |
| title_fullStr | Visual acuity and contrast sensitivity outcomes in Indian eyes undergoing photodynamic therapy with intravitreal injection of triamcinolone acetonide in age-related macular degeneration |
| title_full_unstemmed | Visual acuity and contrast sensitivity outcomes in Indian eyes undergoing photodynamic therapy with intravitreal injection of triamcinolone acetonide in age-related macular degeneration |
| title_short | Visual acuity and contrast sensitivity outcomes in Indian eyes undergoing photodynamic therapy with intravitreal injection of triamcinolone acetonide in age-related macular degeneration |
| title_sort | visual acuity and contrast sensitivity outcomes in indian eyes undergoing photodynamic therapy with intravitreal injection of triamcinolone acetonide in age related macular degeneration |
| topic | Age-related macular degeneration choroidal neovascularization intravitreal triamcinolone photodynamic therapy verteporfin. |
| url | http://www.ijo.in/article.asp?issn=0301-4738;year=2007;volume=55;issue=3;spage=207;epage=211;aulast=Kumar |
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