Impact of Advanced Age on the Clinical Presentation and Outcome of Sporadic Medullary Thyroid Carcinoma
Sporadic medullary thyroid carcinoma (MTC) is a rare malignancy with a heterogeneous clinical course. Several potential prognostic factors have been investigated, but the impact of some of these is controversial, such as age at diagnosis. We evaluated the data of 432 sporadic MTC patients followed-u...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-12-01
|
| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/13/1/94 |
| _version_ | 1797543048505196544 |
|---|---|
| author | Antonio Matrone Carla Gambale Alessandro Prete Paolo Piaggi Virginia Cappagli Valeria Bottici Cristina Romei Raffaele Ciampi Liborio Torregrossa Luigi De Napoli Eleonora Molinaro Gabriele Materazzi Fulvio Basolo Rossella Elisei |
| author_facet | Antonio Matrone Carla Gambale Alessandro Prete Paolo Piaggi Virginia Cappagli Valeria Bottici Cristina Romei Raffaele Ciampi Liborio Torregrossa Luigi De Napoli Eleonora Molinaro Gabriele Materazzi Fulvio Basolo Rossella Elisei |
| author_sort | Antonio Matrone |
| collection | DOAJ |
| description | Sporadic medullary thyroid carcinoma (MTC) is a rare malignancy with a heterogeneous clinical course. Several potential prognostic factors have been investigated, but the impact of some of these is controversial, such as age at diagnosis. We evaluated the data of 432 sporadic MTC patients followed-up for a median of 7.4 years. Patients were divided and compared according to their age at diagnosis in group A (<65 years—n = 338, 78.2%) and group B (≥65 years—n = 94, 21.8%). No differences were detected between the two groups. Median follow-up time was significantly longer in patients <65 than ≥65 years. We observed 41 (9.5%) cancer-related death events. The death rate was similar between the two age groups. However, the Kaplan Meier curve showed a longer survival time for younger patients compared to older patients [HR 2.5 (CI 95%: 1.27–4.94), <i>p</i> < 0.01]. Nevertheless, no differences in the aggressiveness of the disease at presentation and in the number and type of treatments performed were found in the two subgroups of dead patients. In patients with sporadic MTC, age at diagnosis did not correlate with any clinical and pathological features. Cancer-related death events are similar in older and younger patients, but survival time is longer in the younger. |
| first_indexed | 2024-03-10T13:40:08Z |
| format | Article |
| id | doaj.art-de5f0c419fbc466a97b15f38f17c8ba5 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T13:40:08Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-de5f0c419fbc466a97b15f38f17c8ba52023-11-21T03:11:10ZengMDPI AGCancers2072-66942020-12-011319410.3390/cancers13010094Impact of Advanced Age on the Clinical Presentation and Outcome of Sporadic Medullary Thyroid CarcinomaAntonio Matrone0Carla Gambale1Alessandro Prete2Paolo Piaggi3Virginia Cappagli4Valeria Bottici5Cristina Romei6Raffaele Ciampi7Liborio Torregrossa8Luigi De Napoli9Eleonora Molinaro10Gabriele Materazzi11Fulvio Basolo12Rossella Elisei13 Endocrine Unit, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Via Paradisa 2, 56124 Pisa, Italy Endocrine Unit, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Via Paradisa 2, 56124 Pisa, Italy Endocrine Unit, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Via Paradisa 2, 56124 Pisa, ItalyNational Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85016, USA Endocrine Unit, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Via Paradisa 2, 56124 Pisa, Italy Endocrine Unit, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Via Paradisa 2, 56124 Pisa, Italy Endocrine Unit, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Via Paradisa 2, 56124 Pisa, Italy Endocrine Unit, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Via Paradisa 2, 56124 Pisa, ItalyDepartment of Surgical, Medical, Molecular Pathology and Critical Area, University Hospital of Pisa, 56124 Pisa, ItalyUnit of Endocrine Surgery, Department of Surgical, Medical, Molecular Pathology and Critical Area, University Hospital of Pisa, 56124 Pisa, Italy Endocrine Unit, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Via Paradisa 2, 56124 Pisa, ItalyUnit of Endocrine Surgery, Department of Surgical, Medical, Molecular Pathology and Critical Area, University Hospital of Pisa, 56124 Pisa, ItalyDepartment of Surgical, Medical, Molecular Pathology and Critical Area, University Hospital of Pisa, 56124 Pisa, Italy Endocrine Unit, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Via Paradisa 2, 56124 Pisa, ItalySporadic medullary thyroid carcinoma (MTC) is a rare malignancy with a heterogeneous clinical course. Several potential prognostic factors have been investigated, but the impact of some of these is controversial, such as age at diagnosis. We evaluated the data of 432 sporadic MTC patients followed-up for a median of 7.4 years. Patients were divided and compared according to their age at diagnosis in group A (<65 years—n = 338, 78.2%) and group B (≥65 years—n = 94, 21.8%). No differences were detected between the two groups. Median follow-up time was significantly longer in patients <65 than ≥65 years. We observed 41 (9.5%) cancer-related death events. The death rate was similar between the two age groups. However, the Kaplan Meier curve showed a longer survival time for younger patients compared to older patients [HR 2.5 (CI 95%: 1.27–4.94), <i>p</i> < 0.01]. Nevertheless, no differences in the aggressiveness of the disease at presentation and in the number and type of treatments performed were found in the two subgroups of dead patients. In patients with sporadic MTC, age at diagnosis did not correlate with any clinical and pathological features. Cancer-related death events are similar in older and younger patients, but survival time is longer in the younger.https://www.mdpi.com/2072-6694/13/1/94medullary thyroid carcinomasporadicagedistant metastasisdeath rate |
| spellingShingle | Antonio Matrone Carla Gambale Alessandro Prete Paolo Piaggi Virginia Cappagli Valeria Bottici Cristina Romei Raffaele Ciampi Liborio Torregrossa Luigi De Napoli Eleonora Molinaro Gabriele Materazzi Fulvio Basolo Rossella Elisei Impact of Advanced Age on the Clinical Presentation and Outcome of Sporadic Medullary Thyroid Carcinoma Cancers medullary thyroid carcinoma sporadic age distant metastasis death rate |
| title | Impact of Advanced Age on the Clinical Presentation and Outcome of Sporadic Medullary Thyroid Carcinoma |
| title_full | Impact of Advanced Age on the Clinical Presentation and Outcome of Sporadic Medullary Thyroid Carcinoma |
| title_fullStr | Impact of Advanced Age on the Clinical Presentation and Outcome of Sporadic Medullary Thyroid Carcinoma |
| title_full_unstemmed | Impact of Advanced Age on the Clinical Presentation and Outcome of Sporadic Medullary Thyroid Carcinoma |
| title_short | Impact of Advanced Age on the Clinical Presentation and Outcome of Sporadic Medullary Thyroid Carcinoma |
| title_sort | impact of advanced age on the clinical presentation and outcome of sporadic medullary thyroid carcinoma |
| topic | medullary thyroid carcinoma sporadic age distant metastasis death rate |
| url | https://www.mdpi.com/2072-6694/13/1/94 |
| work_keys_str_mv | AT antoniomatrone impactofadvancedageontheclinicalpresentationandoutcomeofsporadicmedullarythyroidcarcinoma AT carlagambale impactofadvancedageontheclinicalpresentationandoutcomeofsporadicmedullarythyroidcarcinoma AT alessandroprete impactofadvancedageontheclinicalpresentationandoutcomeofsporadicmedullarythyroidcarcinoma AT paolopiaggi impactofadvancedageontheclinicalpresentationandoutcomeofsporadicmedullarythyroidcarcinoma AT virginiacappagli impactofadvancedageontheclinicalpresentationandoutcomeofsporadicmedullarythyroidcarcinoma AT valeriabottici impactofadvancedageontheclinicalpresentationandoutcomeofsporadicmedullarythyroidcarcinoma AT cristinaromei impactofadvancedageontheclinicalpresentationandoutcomeofsporadicmedullarythyroidcarcinoma AT raffaeleciampi impactofadvancedageontheclinicalpresentationandoutcomeofsporadicmedullarythyroidcarcinoma AT liboriotorregrossa impactofadvancedageontheclinicalpresentationandoutcomeofsporadicmedullarythyroidcarcinoma AT luigidenapoli impactofadvancedageontheclinicalpresentationandoutcomeofsporadicmedullarythyroidcarcinoma AT eleonoramolinaro impactofadvancedageontheclinicalpresentationandoutcomeofsporadicmedullarythyroidcarcinoma AT gabrielematerazzi impactofadvancedageontheclinicalpresentationandoutcomeofsporadicmedullarythyroidcarcinoma AT fulviobasolo impactofadvancedageontheclinicalpresentationandoutcomeofsporadicmedullarythyroidcarcinoma AT rossellaelisei impactofadvancedageontheclinicalpresentationandoutcomeofsporadicmedullarythyroidcarcinoma |