2.6 BLOOD PRESSURE-INDEPENDENCE OF AORTIC-TO-BRACHIAL ARTERY STIFFNESS RATIO IS DEPENDENT ON DISEASE STATUS
Introduction: Aortic stiffness predicts cardiovascular mortality but is limited as a risk marker because it is dependent on blood pressure (BP). A potential solution is provided from the ratio of aortic-to-brachial artery stiffness (ab-ratio), which is purported to be a BP-independent risk marker am...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2017-12-01
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| Series: | Artery Research |
| Online Access: | https://www.atlantis-press.com/article/125930209/view |
| _version_ | 1818006373011554304 |
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| author | Matthew K. Armstrong Martin G. Schultz Dean S. Picone James E. Sharman |
| author_facet | Matthew K. Armstrong Martin G. Schultz Dean S. Picone James E. Sharman |
| author_sort | Matthew K. Armstrong |
| collection | DOAJ |
| description | Introduction: Aortic stiffness predicts cardiovascular mortality but is limited as a risk marker because it is dependent on blood pressure (BP). A potential solution is provided from the ratio of aortic-to-brachial artery stiffness (ab-ratio), which is purported to be a BP-independent risk marker among patients with renal dysfunction (RD). We sought to determine the BP-independence of the ab-ratio in patients with disease (including RD) and healthy populations.
Methods: The ab-ratio (aortic/brachial pulse wave velocity; PWV) and mean arterial pressure (MAP) were recorded in patients with RD (n = 119, aged 65 ± 7 years), hypertension (n = 140, aged 62 ± 9 years), type 2 diabetes (n = 77, aged 60 ± 9 years) and healthy individuals (n = 99, aged 51 ± 8 years). Multiple-regression analysis was performed to test the independent association of MAP with the ab-ratio adjusted for age, sex, body-mass index and blood glucose.
Results: There was no significant relationship between the ab-ratio and MAP in patients with RD (β = 0.002, 95% CI 0.002, 0.006, p = 0.34), hypertension (β = 0.001, 95% CI 0.003, 0.006, p = 0.62) or diabetes (β = 0.006, 95% CI 0.002, 0.014, p = 0.11). However, in healthy individuals the ab-ratio was significantly and independently associated with MAP (β = 0.008, 95% CI 0.003, 0.013, p = 0.003). There was a significant difference in the strength of association between the ab-ratio and MAP between patients with disease and healthy individuals (z > 2.2, p < 0.05 for all).
Conclusion: Although ab-ratio is purported to be a risk marker that is independent of BP, this was observed only among patient populations, and not in healthy individuals. Therefore, the ab-ratio is influenced by disease status and may have restricted value as a BP-independent risk marker. |
| first_indexed | 2024-04-14T05:00:11Z |
| format | Article |
| id | doaj.art-de60fb844f5a49e6840263f7dff47af1 |
| institution | Directory Open Access Journal |
| issn | 1876-4401 |
| language | English |
| last_indexed | 2024-04-14T05:00:11Z |
| publishDate | 2017-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Artery Research |
| spelling | doaj.art-de60fb844f5a49e6840263f7dff47af12022-12-22T02:11:00ZengBMCArtery Research1876-44012017-12-012010.1016/j.artres.2017.10.0282.6 BLOOD PRESSURE-INDEPENDENCE OF AORTIC-TO-BRACHIAL ARTERY STIFFNESS RATIO IS DEPENDENT ON DISEASE STATUSMatthew K. ArmstrongMartin G. SchultzDean S. PiconeJames E. SharmanIntroduction: Aortic stiffness predicts cardiovascular mortality but is limited as a risk marker because it is dependent on blood pressure (BP). A potential solution is provided from the ratio of aortic-to-brachial artery stiffness (ab-ratio), which is purported to be a BP-independent risk marker among patients with renal dysfunction (RD). We sought to determine the BP-independence of the ab-ratio in patients with disease (including RD) and healthy populations. Methods: The ab-ratio (aortic/brachial pulse wave velocity; PWV) and mean arterial pressure (MAP) were recorded in patients with RD (n = 119, aged 65 ± 7 years), hypertension (n = 140, aged 62 ± 9 years), type 2 diabetes (n = 77, aged 60 ± 9 years) and healthy individuals (n = 99, aged 51 ± 8 years). Multiple-regression analysis was performed to test the independent association of MAP with the ab-ratio adjusted for age, sex, body-mass index and blood glucose. Results: There was no significant relationship between the ab-ratio and MAP in patients with RD (β = 0.002, 95% CI 0.002, 0.006, p = 0.34), hypertension (β = 0.001, 95% CI 0.003, 0.006, p = 0.62) or diabetes (β = 0.006, 95% CI 0.002, 0.014, p = 0.11). However, in healthy individuals the ab-ratio was significantly and independently associated with MAP (β = 0.008, 95% CI 0.003, 0.013, p = 0.003). There was a significant difference in the strength of association between the ab-ratio and MAP between patients with disease and healthy individuals (z > 2.2, p < 0.05 for all). Conclusion: Although ab-ratio is purported to be a risk marker that is independent of BP, this was observed only among patient populations, and not in healthy individuals. Therefore, the ab-ratio is influenced by disease status and may have restricted value as a BP-independent risk marker.https://www.atlantis-press.com/article/125930209/view |
| spellingShingle | Matthew K. Armstrong Martin G. Schultz Dean S. Picone James E. Sharman 2.6 BLOOD PRESSURE-INDEPENDENCE OF AORTIC-TO-BRACHIAL ARTERY STIFFNESS RATIO IS DEPENDENT ON DISEASE STATUS Artery Research |
| title | 2.6 BLOOD PRESSURE-INDEPENDENCE OF AORTIC-TO-BRACHIAL ARTERY STIFFNESS RATIO IS DEPENDENT ON DISEASE STATUS |
| title_full | 2.6 BLOOD PRESSURE-INDEPENDENCE OF AORTIC-TO-BRACHIAL ARTERY STIFFNESS RATIO IS DEPENDENT ON DISEASE STATUS |
| title_fullStr | 2.6 BLOOD PRESSURE-INDEPENDENCE OF AORTIC-TO-BRACHIAL ARTERY STIFFNESS RATIO IS DEPENDENT ON DISEASE STATUS |
| title_full_unstemmed | 2.6 BLOOD PRESSURE-INDEPENDENCE OF AORTIC-TO-BRACHIAL ARTERY STIFFNESS RATIO IS DEPENDENT ON DISEASE STATUS |
| title_short | 2.6 BLOOD PRESSURE-INDEPENDENCE OF AORTIC-TO-BRACHIAL ARTERY STIFFNESS RATIO IS DEPENDENT ON DISEASE STATUS |
| title_sort | 2 6 blood pressure independence of aortic to brachial artery stiffness ratio is dependent on disease status |
| url | https://www.atlantis-press.com/article/125930209/view |
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