Changing clinical significance of oocyte maturity grades with advancing female age advances precision medicine in IVF
Summary: In current IVF practice, metaphase-2 (M2) oocytes are considered most efficient in producing good quality embryos. Maximizing their number at all ages is standard clinical practice, while immature germinal vesicle (GV) oocytes are mostly automatically discarded. We present preliminary evide...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-08-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004223013858 |
| _version_ | 1797772424799846400 |
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| author | Cari Nicholas Sarah Darmon Pasquale Patrizio David F. Albertini David H. Barad Norbert Gleicher |
| author_facet | Cari Nicholas Sarah Darmon Pasquale Patrizio David F. Albertini David H. Barad Norbert Gleicher |
| author_sort | Cari Nicholas |
| collection | DOAJ |
| description | Summary: In current IVF practice, metaphase-2 (M2) oocytes are considered most efficient in producing good quality embryos. Maximizing their number at all ages is standard clinical practice, while immature germinal vesicle (GV) oocytes are mostly automatically discarded. We present preliminary evidence that oocyte maturity grades with advancing age significantly change in their abilities to produce good quality embryos, with M2 oocytes significantly declining, GV oocytes improving, and M1 oocytes staying the same. These data contradict the over-40-year-old dogma that oocyte grades functionally do not change with advancing age, supporting potential changes to current IVF practice: (1) Stimulation protocols and timing of oocyte retrieval can be adjusted to a patient’s age and ovarian function. (2) In older and younger women with prematurely aging ovaries, GV oocytes may no longer be automatically discarded. (3) In some infertile women, rescue in vitro maturation of immature oocytes may delay the need for third-party egg donation. |
| first_indexed | 2024-03-12T21:50:39Z |
| format | Article |
| id | doaj.art-de61229ff83c4d8e9e5aeb4959a15e10 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-03-12T21:50:39Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-de61229ff83c4d8e9e5aeb4959a15e102023-07-26T04:09:34ZengElsevieriScience2589-00422023-08-01268107308Changing clinical significance of oocyte maturity grades with advancing female age advances precision medicine in IVFCari Nicholas0Sarah Darmon1Pasquale Patrizio2David F. Albertini3David H. Barad4Norbert Gleicher5Center for Human Reproduction, New York, NY, USACenter for Human Reproduction, New York, NY, USACenter for Human Reproduction, New York, NY, USA; Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Miami, Miller School of Medicine, Miami, FL, USACenter for Human Reproduction, New York, NY, USA; Bedford Research Foundation, Bedford, MA, USACenter for Human Reproduction, New York, NY, USA; Foundation for Reproductive Medicine, New York, NY, USACenter for Human Reproduction, New York, NY, USA; Foundation for Reproductive Medicine, New York, NY, USA; Stem Cell Biology and Molecular Embryology Laboratory, The Rockefeller University, New York, NY, USA; Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria; Corresponding authorSummary: In current IVF practice, metaphase-2 (M2) oocytes are considered most efficient in producing good quality embryos. Maximizing their number at all ages is standard clinical practice, while immature germinal vesicle (GV) oocytes are mostly automatically discarded. We present preliminary evidence that oocyte maturity grades with advancing age significantly change in their abilities to produce good quality embryos, with M2 oocytes significantly declining, GV oocytes improving, and M1 oocytes staying the same. These data contradict the over-40-year-old dogma that oocyte grades functionally do not change with advancing age, supporting potential changes to current IVF practice: (1) Stimulation protocols and timing of oocyte retrieval can be adjusted to a patient’s age and ovarian function. (2) In older and younger women with prematurely aging ovaries, GV oocytes may no longer be automatically discarded. (3) In some infertile women, rescue in vitro maturation of immature oocytes may delay the need for third-party egg donation.http://www.sciencedirect.com/science/article/pii/S2589004223013858Women’s healthReproductive medicineCell biology |
| spellingShingle | Cari Nicholas Sarah Darmon Pasquale Patrizio David F. Albertini David H. Barad Norbert Gleicher Changing clinical significance of oocyte maturity grades with advancing female age advances precision medicine in IVF iScience Women’s health Reproductive medicine Cell biology |
| title | Changing clinical significance of oocyte maturity grades with advancing female age advances precision medicine in IVF |
| title_full | Changing clinical significance of oocyte maturity grades with advancing female age advances precision medicine in IVF |
| title_fullStr | Changing clinical significance of oocyte maturity grades with advancing female age advances precision medicine in IVF |
| title_full_unstemmed | Changing clinical significance of oocyte maturity grades with advancing female age advances precision medicine in IVF |
| title_short | Changing clinical significance of oocyte maturity grades with advancing female age advances precision medicine in IVF |
| title_sort | changing clinical significance of oocyte maturity grades with advancing female age advances precision medicine in ivf |
| topic | Women’s health Reproductive medicine Cell biology |
| url | http://www.sciencedirect.com/science/article/pii/S2589004223013858 |
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