Synthesis and Trace-Level Quantification of Mutagenic and Cohort-of-Concern Ciprofloxacin Nitroso Drug Substance-Related Impurities (NDSRIs) and Other Nitroso Impurities Using UPLC-ESI-MS/MSMethod Optimization Using I‑Optimal Mixture Design

Synthesis and Trace-Level Quantification of Mutagenic and Cohort-of-Concern Ciprofloxacin Nitroso Drug Substance-Related Impurities (NDSRIs) and Other Nitroso Impurities Using UPLC-ESI-MS/MSMethod Optimization Using I‑Optimal Mixture Design

Bibliographic Details
Main Authors: Srinivas Nakka, Naresh Kumar Katari, Siva Krishna Muchakayala, Sreekantha Babu Jonnalagadda, Surendra Babu Manabolu Surya
Format: Article
Language:English
Published: American Chemical Society 2024-02-01
Series:ACS Omega
Online Access:https://doi.org/10.1021/acsomega.3c05170

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