Exploiting frequent and specific expression of PRL3 in pediatric solid tumors for first-in-child use of PRL3-zumab humanized antibody

Exploiting frequent and specific expression of PRL3 in pediatric solid tumors for first-in-child use of PRL3-zumab humanized antibody

Phosphatase of regenerating liver 3 (PRL3) is a specific tumor antigen overexpressed in a broad range of adult cancer types. However, its physiological expression in pediatric embryonal and mesenchymal tumors and its association with clinical outcomes in children is unknown. We sought to profile the...

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Bibliographic Details
Main Authors: Amos Hong Pheng Loh, Min Thura, Abhishek Gupta, Sheng Hui Tan, Kelvin Kam Yew Kuan, Koon Hwee Ang, Khurshid Merchant, Kenneth Tou En Chang, Hui Yi Yon, Yong Chen, Mathew Hern Wang Cheng, Arjandas Mahadev, Matthew Chau Hsien Ng, Michaela Su-Fern Seng, Prasad Iyer, Pei Ling Chia, Shui Yen Soh, Qi Zeng
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Molecular Therapy: Oncolytics
Subjects:
PRL3
PTP4A3, PRL3-zumab
pediatric tumors
neuroblastoma
rhabdomyosarcoma
non-rhabdomyosarcoma soft tissue sarcoma
Online Access:http://www.sciencedirect.com/science/article/pii/S237277052300061X

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