Interplay between P-Glycoprotein Expression and Resistance to Endoplasmic Reticulum Stressors

Interplay between P-Glycoprotein Expression and Resistance to Endoplasmic Reticulum Stressors

Multidrug resistance (MDR) is a phenotype of cancer cells with reduced sensitivity to a wide range of unrelated drugs. P-glycoprotein (P-gp)—a drug efflux pump (ABCB1 member of the ABC transporter gene family)—is frequently observed to be a molecular cause of MDR. The drug-efflux activity of P-gp is...

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Bibliographic Details
Main Authors: Milan Hano, Lenka Tomášová, Mário Šereš, Lucia Pavlíková, Albert Breier, Zdena Sulová
Format: Article
Language:English
Published: MDPI AG 2018-02-01
Series:Molecules
Subjects:
multidrug resistance
P-glycoprotein
ER stress
unfolded protein response
ERAD
N-glycosylation
malignancies
Online Access:http://www.mdpi.com/1420-3049/23/2/337

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