Tryptophan metabolic pathway and neopterin in asthmatic children in clinical practice
Abstract Tryptophan metabolic pathway is involved in pathogenic mechanisms of asthma. This study aimed to evaluate tryptophan metabolites and neopterin in a group of asthmatic children. Tryptophan metabolites and neopterin were measured in asthmatic children (121, 71 males, 50 females, mean age 11.6...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-08-01
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| Series: | Italian Journal of Pediatrics |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13052-019-0699-6 |
| _version_ | 1818443499715952640 |
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| author | Amelia Licari Dietmar Fuchs Gianluigi Marseglia Giorgio Ciprandi |
| author_facet | Amelia Licari Dietmar Fuchs Gianluigi Marseglia Giorgio Ciprandi |
| author_sort | Amelia Licari |
| collection | DOAJ |
| description | Abstract Tryptophan metabolic pathway is involved in pathogenic mechanisms of asthma. This study aimed to evaluate tryptophan metabolites and neopterin in a group of asthmatic children. Tryptophan metabolites and neopterin were measured in asthmatic children (121, 71 males, 50 females, mean age 11.6 + 3.2 years) and well-matched healthy controls (63, 32 males, 31 females, mean age 10.7 + 2.6 years). Tryptophan, kynurenine, and neopterin levels were significantly higher in asthmatic children than in healthy controls (p < 0.01; p < 0.01; p = 0.0015 respectively). Tryptophan metabolites and neopterin are increased in asthmatic children; these mediators underline the complex mechanisms involved in the immune response in asthma. |
| first_indexed | 2024-12-14T19:01:01Z |
| format | Article |
| id | doaj.art-de66185916c147969ce2fa9fc5ecec3b |
| institution | Directory Open Access Journal |
| issn | 1824-7288 |
| language | English |
| last_indexed | 2024-12-14T19:01:01Z |
| publishDate | 2019-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Italian Journal of Pediatrics |
| spelling | doaj.art-de66185916c147969ce2fa9fc5ecec3b2022-12-21T22:50:58ZengBMCItalian Journal of Pediatrics1824-72882019-08-014511410.1186/s13052-019-0699-6Tryptophan metabolic pathway and neopterin in asthmatic children in clinical practiceAmelia Licari0Dietmar Fuchs1Gianluigi Marseglia2Giorgio Ciprandi3Pediatrics Clinic, Department of Pediatrics, Ospedale San Matteo, University of PaviaBiological Chemistry, Biocenter, Innsbruck Medical UniversityPediatrics Clinic, Department of Pediatrics, Ospedale San Matteo, University of PaviaAllergy Clinic, Casa di Cura Villa MontallegroAbstract Tryptophan metabolic pathway is involved in pathogenic mechanisms of asthma. This study aimed to evaluate tryptophan metabolites and neopterin in a group of asthmatic children. Tryptophan metabolites and neopterin were measured in asthmatic children (121, 71 males, 50 females, mean age 11.6 + 3.2 years) and well-matched healthy controls (63, 32 males, 31 females, mean age 10.7 + 2.6 years). Tryptophan, kynurenine, and neopterin levels were significantly higher in asthmatic children than in healthy controls (p < 0.01; p < 0.01; p = 0.0015 respectively). Tryptophan metabolites and neopterin are increased in asthmatic children; these mediators underline the complex mechanisms involved in the immune response in asthma.http://link.springer.com/article/10.1186/s13052-019-0699-6TryptophanKynurenineNeopterinAsthmaChildren |
| spellingShingle | Amelia Licari Dietmar Fuchs Gianluigi Marseglia Giorgio Ciprandi Tryptophan metabolic pathway and neopterin in asthmatic children in clinical practice Italian Journal of Pediatrics Tryptophan Kynurenine Neopterin Asthma Children |
| title | Tryptophan metabolic pathway and neopterin in asthmatic children in clinical practice |
| title_full | Tryptophan metabolic pathway and neopterin in asthmatic children in clinical practice |
| title_fullStr | Tryptophan metabolic pathway and neopterin in asthmatic children in clinical practice |
| title_full_unstemmed | Tryptophan metabolic pathway and neopterin in asthmatic children in clinical practice |
| title_short | Tryptophan metabolic pathway and neopterin in asthmatic children in clinical practice |
| title_sort | tryptophan metabolic pathway and neopterin in asthmatic children in clinical practice |
| topic | Tryptophan Kynurenine Neopterin Asthma Children |
| url | http://link.springer.com/article/10.1186/s13052-019-0699-6 |
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