Rheumatic diseases and viral infection: is there an association?
Viral infections, hepatitis B and C and herpesvirus-induced infections in particular, are widespread in the population. Recent years have seen the emergence of new viral infections that were previously endemic. Understanding the role of viruses in the pathogenesis of rheumatic diseases (RDs) is of g...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
IMA-PRESS LLC
2020-11-01
|
| Series: | Современная ревматология |
| Subjects: | |
| Online Access: | https://mrj.ima-press.net/mrj/article/view/1075 |
| _version_ | 1797876703401345024 |
|---|---|
| author | R. M. Balabanova |
| author_facet | R. M. Balabanova |
| author_sort | R. M. Balabanova |
| collection | DOAJ |
| description | Viral infections, hepatitis B and C and herpesvirus-induced infections in particular, are widespread in the population. Recent years have seen the emergence of new viral infections that were previously endemic. Understanding the role of viruses in the pathogenesis of rheumatic diseases (RDs) is of great importance. First, they cause the clinical manifestations characteristic of many RDs (systemic lupus erythematosus, rheumatoid arthritis, polymyositis, and Sjö gren's disease). The author discusses several possible mechanisms of the involvement of viruses in the development of autoimmune disorders: molecular mimicry; polyclonal B cell activation with overproduction of antibodies and immune complexes; T cell activation with cytokine overproduction. Secondly, viral infection can be reactivated during immunosuppressive therapy (also using biological agents), which is widely used to treat RDs. The review presents data on both the most common viruses (hepatitis B and C viruses, HIV, and human herpesviruses types 1–6) and more rare ones (chikungunya virus and polyomavirus) in the Russian population. |
| first_indexed | 2024-04-10T02:06:49Z |
| format | Article |
| id | doaj.art-de665347136848a49a843c91a98c1eb4 |
| institution | Directory Open Access Journal |
| issn | 1996-7012 2310-158X |
| language | Russian |
| last_indexed | 2024-04-10T02:06:49Z |
| publishDate | 2020-11-01 |
| publisher | IMA-PRESS LLC |
| record_format | Article |
| series | Современная ревматология |
| spelling | doaj.art-de665347136848a49a843c91a98c1eb42023-03-13T08:39:28ZrusIMA-PRESS LLCСовременная ревматология1996-70122310-158X2020-11-011449810210.14412/1996-7012-2020-4-98-1022303Rheumatic diseases and viral infection: is there an association?R. M. Balabanova0ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»Viral infections, hepatitis B and C and herpesvirus-induced infections in particular, are widespread in the population. Recent years have seen the emergence of new viral infections that were previously endemic. Understanding the role of viruses in the pathogenesis of rheumatic diseases (RDs) is of great importance. First, they cause the clinical manifestations characteristic of many RDs (systemic lupus erythematosus, rheumatoid arthritis, polymyositis, and Sjö gren's disease). The author discusses several possible mechanisms of the involvement of viruses in the development of autoimmune disorders: molecular mimicry; polyclonal B cell activation with overproduction of antibodies and immune complexes; T cell activation with cytokine overproduction. Secondly, viral infection can be reactivated during immunosuppressive therapy (also using biological agents), which is widely used to treat RDs. The review presents data on both the most common viruses (hepatitis B and C viruses, HIV, and human herpesviruses types 1–6) and more rare ones (chikungunya virus and polyomavirus) in the Russian population.https://mrj.ima-press.net/mrj/article/view/1075ревматические заболеваниявирусы гепатита всвичгерпесвирусы человека 1–6-го типоввирус чукунгуньяполиомавирусиммуносупрессивная терапия |
| spellingShingle | R. M. Balabanova Rheumatic diseases and viral infection: is there an association? Современная ревматология ревматические заболевания вирусы гепатита в с вич герпесвирусы человека 1–6-го типов вирус чукунгунья полиомавирус иммуносупрессивная терапия |
| title | Rheumatic diseases and viral infection: is there an association? |
| title_full | Rheumatic diseases and viral infection: is there an association? |
| title_fullStr | Rheumatic diseases and viral infection: is there an association? |
| title_full_unstemmed | Rheumatic diseases and viral infection: is there an association? |
| title_short | Rheumatic diseases and viral infection: is there an association? |
| title_sort | rheumatic diseases and viral infection is there an association |
| topic | ревматические заболевания вирусы гепатита в с вич герпесвирусы человека 1–6-го типов вирус чукунгунья полиомавирус иммуносупрессивная терапия |
| url | https://mrj.ima-press.net/mrj/article/view/1075 |
| work_keys_str_mv | AT rmbalabanova rheumaticdiseasesandviralinfectionisthereanassociation |