Clinical Utility of Increased Nuchal Translucency at 11–13 Weeks of Gestation in Twin Pregnancies Based on the Chorionicity
To assess clinical implications of increased nuchal translucency (INT) in twin pregnancies based on the chorionicity. This was a retrospective review of the twin pregnancies who underwent first trimester ultrasound with nuchal translucency (NT) measurement at 11–13 weeks of gestation from January 20...
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MDPI AG
2021-01-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/3/433 |
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| author | SiWon Lee Hyun-Mi Lee You Jung Han Moon Young Kim Hye Yeon Boo Jin Hoon Chung |
| author_facet | SiWon Lee Hyun-Mi Lee You Jung Han Moon Young Kim Hye Yeon Boo Jin Hoon Chung |
| author_sort | SiWon Lee |
| collection | DOAJ |
| description | To assess clinical implications of increased nuchal translucency (INT) in twin pregnancies based on the chorionicity. This was a retrospective review of the twin pregnancies who underwent first trimester ultrasound with nuchal translucency (NT) measurement at 11–13 weeks of gestation from January 2006 to December 2014. Data were collected using the OB database and the chart review. Pregnancy outcomes, including gestational weeks at the delivery, abnormal fetal karyotypes, fetal structural anomalies, and twin-specific complications, were analyzed. A total of 1622 twin pregnancies with INT ≥ 95th percentile in one or both fetuses were identified. In all twin pregnancies with INT, abnormal fetal karyotypes were identified in 17 (8.6%) patients (odds ratio = 13.28, CI = 5.990–29.447, <i>p</i> = 0.000) and twin-specific complications were identified in 23 (11.6%) patients (odds ratio = 2.398, CI = 1.463–3.928, <i>p</i> = 0.001) compared to those with normal NT. Among the INT group, when the groups were subdivided into monochorionic (MC) and dichorionic (DC) pregnancies, 14.8% and 29.6% of the MC pregnancies had structural anomalies in one or both fetuses (odds ratio = 5.774, 95% CI = 1.445–23.071, <i>p</i> = 0.01) and twin-specific complications (odds ratio = 4.379, 95% CI = 1.641–11.684, <i>p</i> = 0.03), respectively, compared to DC pregnancies with 2.9% for structural anomalies and 8.8% for twin-specific complications. The prevalence of abnormal fetal karyotypes was not statistically different in patients with INT when compared between MC and DC pregnancies (<i>p</i> = 0.329). INT was associated with a higher rate of twin-specific complications and fetal structural anomalies in MC twin pregnancies rather than abnormal fetal karyotype. Therefore, NT measurement in MC twin pregnancies can be a useful tool for predicting adverse pregnancy outcomes. Appropriate counseling and surveillance based on the chorionicity are imperative in the prenatal care of twin pregnancies. |
| first_indexed | 2024-03-09T03:53:53Z |
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| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T03:53:53Z |
| publishDate | 2021-01-01 |
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| spelling | doaj.art-de668e9b6e3f46ce8e8850cd63e5087f2023-12-03T14:23:52ZengMDPI AGJournal of Clinical Medicine2077-03832021-01-0110343310.3390/jcm10030433Clinical Utility of Increased Nuchal Translucency at 11–13 Weeks of Gestation in Twin Pregnancies Based on the ChorionicitySiWon Lee0Hyun-Mi Lee1You Jung Han2Moon Young Kim3Hye Yeon Boo4Jin Hoon Chung5Department of Obstetrics and Gynecology, Mount Sinai Medical Center, Miami Beach, FL 33109, USADepartment of Obstetrics and Gynecology, CHA Ilsan Medical Center, CHA University, Goyang 10414, KoreaDepartment of Obstetrics and Gynecology, CHA Gangnam Medical Center, CHA University, Seoul 06135, KoreaDepartment of Obstetrics and Gynecology, CHA Gangnam Medical Center, CHA University, Seoul 06135, KoreaDepartment of Obstetrics and Gynecology, CHA Ilsan Medical Center, CHA University, Goyang 10414, KoreaDepartment of Obstetrics and Gynecology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, KoreaTo assess clinical implications of increased nuchal translucency (INT) in twin pregnancies based on the chorionicity. This was a retrospective review of the twin pregnancies who underwent first trimester ultrasound with nuchal translucency (NT) measurement at 11–13 weeks of gestation from January 2006 to December 2014. Data were collected using the OB database and the chart review. Pregnancy outcomes, including gestational weeks at the delivery, abnormal fetal karyotypes, fetal structural anomalies, and twin-specific complications, were analyzed. A total of 1622 twin pregnancies with INT ≥ 95th percentile in one or both fetuses were identified. In all twin pregnancies with INT, abnormal fetal karyotypes were identified in 17 (8.6%) patients (odds ratio = 13.28, CI = 5.990–29.447, <i>p</i> = 0.000) and twin-specific complications were identified in 23 (11.6%) patients (odds ratio = 2.398, CI = 1.463–3.928, <i>p</i> = 0.001) compared to those with normal NT. Among the INT group, when the groups were subdivided into monochorionic (MC) and dichorionic (DC) pregnancies, 14.8% and 29.6% of the MC pregnancies had structural anomalies in one or both fetuses (odds ratio = 5.774, 95% CI = 1.445–23.071, <i>p</i> = 0.01) and twin-specific complications (odds ratio = 4.379, 95% CI = 1.641–11.684, <i>p</i> = 0.03), respectively, compared to DC pregnancies with 2.9% for structural anomalies and 8.8% for twin-specific complications. The prevalence of abnormal fetal karyotypes was not statistically different in patients with INT when compared between MC and DC pregnancies (<i>p</i> = 0.329). INT was associated with a higher rate of twin-specific complications and fetal structural anomalies in MC twin pregnancies rather than abnormal fetal karyotype. Therefore, NT measurement in MC twin pregnancies can be a useful tool for predicting adverse pregnancy outcomes. Appropriate counseling and surveillance based on the chorionicity are imperative in the prenatal care of twin pregnancies.https://www.mdpi.com/2077-0383/10/3/433twin pregnancynuchal translucencychorionicityanomalytwin complications |
| spellingShingle | SiWon Lee Hyun-Mi Lee You Jung Han Moon Young Kim Hye Yeon Boo Jin Hoon Chung Clinical Utility of Increased Nuchal Translucency at 11–13 Weeks of Gestation in Twin Pregnancies Based on the Chorionicity Journal of Clinical Medicine twin pregnancy nuchal translucency chorionicity anomaly twin complications |
| title | Clinical Utility of Increased Nuchal Translucency at 11–13 Weeks of Gestation in Twin Pregnancies Based on the Chorionicity |
| title_full | Clinical Utility of Increased Nuchal Translucency at 11–13 Weeks of Gestation in Twin Pregnancies Based on the Chorionicity |
| title_fullStr | Clinical Utility of Increased Nuchal Translucency at 11–13 Weeks of Gestation in Twin Pregnancies Based on the Chorionicity |
| title_full_unstemmed | Clinical Utility of Increased Nuchal Translucency at 11–13 Weeks of Gestation in Twin Pregnancies Based on the Chorionicity |
| title_short | Clinical Utility of Increased Nuchal Translucency at 11–13 Weeks of Gestation in Twin Pregnancies Based on the Chorionicity |
| title_sort | clinical utility of increased nuchal translucency at 11 13 weeks of gestation in twin pregnancies based on the chorionicity |
| topic | twin pregnancy nuchal translucency chorionicity anomaly twin complications |
| url | https://www.mdpi.com/2077-0383/10/3/433 |
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