Enhanced immunocompatibility of ligand-targeted liposomes by attenuating natural IgM absorption
Targeting ligands on drug carriers can trigger immune responses. Here, the authors modify liposomes with a peptidomimetic that preserves bioactivity of the nanocarrier in blood circulation and attenuates IgM absorption, thereby improving the immunocompatibility of brain-targeted liposomes.
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-05384-1 |
| _version_ | 1818978492859023360 |
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| author | Juan Guan Qing Shen Zui Zhang Zhuxuan Jiang Yang Yang Meiqing Lou Jun Qian Weiyue Lu Changyou Zhan |
| author_facet | Juan Guan Qing Shen Zui Zhang Zhuxuan Jiang Yang Yang Meiqing Lou Jun Qian Weiyue Lu Changyou Zhan |
| author_sort | Juan Guan |
| collection | DOAJ |
| description | Targeting ligands on drug carriers can trigger immune responses. Here, the authors modify liposomes with a peptidomimetic that preserves bioactivity of the nanocarrier in blood circulation and attenuates IgM absorption, thereby improving the immunocompatibility of brain-targeted liposomes. |
| first_indexed | 2024-12-20T16:44:30Z |
| format | Article |
| id | doaj.art-de6780060c3d401faf616e76a93f9070 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T16:44:30Z |
| publishDate | 2018-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-de6780060c3d401faf616e76a93f90702022-12-21T19:32:58ZengNature PortfolioNature Communications2041-17232018-07-019111110.1038/s41467-018-05384-1Enhanced immunocompatibility of ligand-targeted liposomes by attenuating natural IgM absorptionJuan Guan0Qing Shen1Zui Zhang2Zhuxuan Jiang3Yang Yang4Meiqing Lou5Jun Qian6Weiyue Lu7Changyou Zhan8School of Basic Medical Sciences & State Key Laboratory of Molecular Engineering of Polymers, Fudan UniversityState Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong UniversitySchool of Basic Medical Sciences & State Key Laboratory of Molecular Engineering of Polymers, Fudan UniversitySchool of Basic Medical Sciences & State Key Laboratory of Molecular Engineering of Polymers, Fudan UniversitySchool of Basic Medical Sciences & State Key Laboratory of Molecular Engineering of Polymers, Fudan UniversityDepartment of Neurosurgery, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong UniversitySchool of Pharmacy, Fudan University & Key Laboratory of Smart Drug Delivery (Fudan University), Ministry of EducationSchool of Pharmacy, Fudan University & Key Laboratory of Smart Drug Delivery (Fudan University), Ministry of EducationSchool of Basic Medical Sciences & State Key Laboratory of Molecular Engineering of Polymers, Fudan UniversityTargeting ligands on drug carriers can trigger immune responses. Here, the authors modify liposomes with a peptidomimetic that preserves bioactivity of the nanocarrier in blood circulation and attenuates IgM absorption, thereby improving the immunocompatibility of brain-targeted liposomes.https://doi.org/10.1038/s41467-018-05384-1 |
| spellingShingle | Juan Guan Qing Shen Zui Zhang Zhuxuan Jiang Yang Yang Meiqing Lou Jun Qian Weiyue Lu Changyou Zhan Enhanced immunocompatibility of ligand-targeted liposomes by attenuating natural IgM absorption Nature Communications |
| title | Enhanced immunocompatibility of ligand-targeted liposomes by attenuating natural IgM absorption |
| title_full | Enhanced immunocompatibility of ligand-targeted liposomes by attenuating natural IgM absorption |
| title_fullStr | Enhanced immunocompatibility of ligand-targeted liposomes by attenuating natural IgM absorption |
| title_full_unstemmed | Enhanced immunocompatibility of ligand-targeted liposomes by attenuating natural IgM absorption |
| title_short | Enhanced immunocompatibility of ligand-targeted liposomes by attenuating natural IgM absorption |
| title_sort | enhanced immunocompatibility of ligand targeted liposomes by attenuating natural igm absorption |
| url | https://doi.org/10.1038/s41467-018-05384-1 |
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