Clinical and Pathological Profiles of Vertebral Bone Metastases from Endometrial Cancers: Evidence from a Twenty-Year Case Series
Patients with endometrial cancer (EC) frequently have metastases to lungs, extra-pelvic nodes, and liver. Although an uncommon occurrence, cases of EC metastasis to bone, prevalently in vertebral bone, have also been reported. The objective of this study was to analyze clinical and pathological prof...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/12/2941 |
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| author | Stefano Bandiera Francesca Salamanna Veronica Borsari Deyanira Contartese Marco Bontempi Matilde Tschon Giovanni Tosini Stefano Pasini Silvia Terzi Milena Fini Alessandro Gasbarrini |
| author_facet | Stefano Bandiera Francesca Salamanna Veronica Borsari Deyanira Contartese Marco Bontempi Matilde Tschon Giovanni Tosini Stefano Pasini Silvia Terzi Milena Fini Alessandro Gasbarrini |
| author_sort | Stefano Bandiera |
| collection | DOAJ |
| description | Patients with endometrial cancer (EC) frequently have metastases to lungs, extra-pelvic nodes, and liver. Although an uncommon occurrence, cases of EC metastasis to bone, prevalently in vertebral bone, have also been reported. The objective of this study was to analyze clinical and pathological profiles of patients with EC metastatic to vertebral bone. We carried out a retrospective case series on surgically treated patients for this pathology. From 2001 to 2021, out of 775 patients with bone metastasis, 1.6% had bone metastasis from EC. The median time between the diagnosis of primary tumor and that of bone metastases was 31.5 months. Solitary bone lesion was present in 7 patients and lumbar vertebrae were the segments most affected. Pathological fractures in 46.2% of patients and spinal pain in all were present. In terms of location, 46.2% of bone metastases resided within the anterior section of the vertebra, while the remaining presented an extension within the anterior and posterior sections, with 46.1% of cases showing an extradural extra-osseous extension and paraspinous envelope. Median survival after diagnosis of bone metastasis was 11.5 months. Vertebral bone metastasis in EC is a rare phenomenon, with severe prognosis. An in-depth understanding of this topic may guide future management and treatment decisions, thus improving life expectancy and quality. |
| first_indexed | 2024-03-09T17:08:48Z |
| format | Article |
| id | doaj.art-de680bf0bbd4415899972b1ef236db14 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T17:08:48Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-de680bf0bbd4415899972b1ef236db142023-11-24T14:15:56ZengMDPI AGDiagnostics2075-44182022-11-011212294110.3390/diagnostics12122941Clinical and Pathological Profiles of Vertebral Bone Metastases from Endometrial Cancers: Evidence from a Twenty-Year Case SeriesStefano Bandiera0Francesca Salamanna1Veronica Borsari2Deyanira Contartese3Marco Bontempi4Matilde Tschon5Giovanni Tosini6Stefano Pasini7Silvia Terzi8Milena Fini9Alessandro Gasbarrini10Spine Surgery Unit, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, ItalyComplex Structure of Surgical Sciences and Technologies, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, ItalyComplex Structure of Surgical Sciences and Technologies, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, ItalyComplex Structure of Surgical Sciences and Technologies, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, ItalyComplex Structure of Surgical Sciences and Technologies, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, ItalyComplex Structure of Surgical Sciences and Technologies, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, ItalySpine Surgery Unit, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, ItalySpine Surgery Unit, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, ItalySpine Surgery Unit, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, ItalyScientific Direction, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, ItalySpine Surgery Unit, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, ItalyPatients with endometrial cancer (EC) frequently have metastases to lungs, extra-pelvic nodes, and liver. Although an uncommon occurrence, cases of EC metastasis to bone, prevalently in vertebral bone, have also been reported. The objective of this study was to analyze clinical and pathological profiles of patients with EC metastatic to vertebral bone. We carried out a retrospective case series on surgically treated patients for this pathology. From 2001 to 2021, out of 775 patients with bone metastasis, 1.6% had bone metastasis from EC. The median time between the diagnosis of primary tumor and that of bone metastases was 31.5 months. Solitary bone lesion was present in 7 patients and lumbar vertebrae were the segments most affected. Pathological fractures in 46.2% of patients and spinal pain in all were present. In terms of location, 46.2% of bone metastases resided within the anterior section of the vertebra, while the remaining presented an extension within the anterior and posterior sections, with 46.1% of cases showing an extradural extra-osseous extension and paraspinous envelope. Median survival after diagnosis of bone metastasis was 11.5 months. Vertebral bone metastasis in EC is a rare phenomenon, with severe prognosis. An in-depth understanding of this topic may guide future management and treatment decisions, thus improving life expectancy and quality.https://www.mdpi.com/2075-4418/12/12/2941bone metastasisvertebral boneendometrial cancerclinical-pathological characteristicssurvival |
| spellingShingle | Stefano Bandiera Francesca Salamanna Veronica Borsari Deyanira Contartese Marco Bontempi Matilde Tschon Giovanni Tosini Stefano Pasini Silvia Terzi Milena Fini Alessandro Gasbarrini Clinical and Pathological Profiles of Vertebral Bone Metastases from Endometrial Cancers: Evidence from a Twenty-Year Case Series Diagnostics bone metastasis vertebral bone endometrial cancer clinical-pathological characteristics survival |
| title | Clinical and Pathological Profiles of Vertebral Bone Metastases from Endometrial Cancers: Evidence from a Twenty-Year Case Series |
| title_full | Clinical and Pathological Profiles of Vertebral Bone Metastases from Endometrial Cancers: Evidence from a Twenty-Year Case Series |
| title_fullStr | Clinical and Pathological Profiles of Vertebral Bone Metastases from Endometrial Cancers: Evidence from a Twenty-Year Case Series |
| title_full_unstemmed | Clinical and Pathological Profiles of Vertebral Bone Metastases from Endometrial Cancers: Evidence from a Twenty-Year Case Series |
| title_short | Clinical and Pathological Profiles of Vertebral Bone Metastases from Endometrial Cancers: Evidence from a Twenty-Year Case Series |
| title_sort | clinical and pathological profiles of vertebral bone metastases from endometrial cancers evidence from a twenty year case series |
| topic | bone metastasis vertebral bone endometrial cancer clinical-pathological characteristics survival |
| url | https://www.mdpi.com/2075-4418/12/12/2941 |
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