Obstructive sleep apnoea-related respiratory events and desaturation severity are associated with the cardiac response
Background Obstructive sleep apnoea (OSA) causes, among other things, intermittent blood oxygen desaturations, increasing the sympathetic tone. Yet the effect of desaturations on heart rate variability (HRV), a simple and noninvasive method for assessing sympathovagal balance, has not been comprehen...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
European Respiratory Society
2022-10-01
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| Series: | ERJ Open Research |
| Online Access: | http://openres.ersjournals.com/content/8/4/00121-2022.full |
| _version_ | 1797809464552718336 |
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| author | Salla Hietakoste Tuomas Karhu Saara Sillanmäki Raquel Bailón Thomas Penzel Juha Töyräs Timo Leppänen Sami Myllymaa Samu Kainulainen |
| author_facet | Salla Hietakoste Tuomas Karhu Saara Sillanmäki Raquel Bailón Thomas Penzel Juha Töyräs Timo Leppänen Sami Myllymaa Samu Kainulainen |
| author_sort | Salla Hietakoste |
| collection | DOAJ |
| description | Background
Obstructive sleep apnoea (OSA) causes, among other things, intermittent blood oxygen desaturations, increasing the sympathetic tone. Yet the effect of desaturations on heart rate variability (HRV), a simple and noninvasive method for assessing sympathovagal balance, has not been comprehensively studied. We aimed to study whether desaturation severity affects the immediate HRV.
Methods
We retrospectively analysed the electrocardiography signals in 5-min segments (n=39 132) recorded during clinical polysomnographies of 642 patients with suspected OSA. HRV parameters were calculated for each segment. The segments were pooled into severity groups based on the desaturation severity (i.e. the integrated area under the blood oxygen saturation curve) and the respiratory event rate within the segment. Covariate-adjusted regression analyses were performed to investigate possible confounding effects.
Results
With increasing respiratory event rate, the normalised high-frequency band power (HFNU) decreased from 0.517 to 0.364 (p<0.01), the normalised low-frequency band power (LFNU) increased from 0.483 to 0.636 (p<0.01) and the mean RR interval decreased from 915 to 869 ms (p<0.01). Similarly, with increasing desaturation severity, the HFNU decreased from 0.499 to 0.364 (p<0.01), the LFNU increased from 0.501 to 0.636 (p<0.01) and the mean RR interval decreased from 952 to 854 ms (p<0.01). Desaturation severity-related findings were confirmed by considering the confounding factors in the regression analyses.
Conclusion
The short-term HRV response differs based on the desaturation severity and the respiratory event rate in patients with suspected OSA. Therefore, a more detailed analysis of HRV and desaturation characteristics could enhance OSA severity estimation. |
| first_indexed | 2024-03-13T06:53:12Z |
| format | Article |
| id | doaj.art-de6c8bef099b46aba1ff9b5e24bcd070 |
| institution | Directory Open Access Journal |
| issn | 2312-0541 |
| language | English |
| last_indexed | 2024-03-13T06:53:12Z |
| publishDate | 2022-10-01 |
| publisher | European Respiratory Society |
| record_format | Article |
| series | ERJ Open Research |
| spelling | doaj.art-de6c8bef099b46aba1ff9b5e24bcd0702023-06-07T13:30:36ZengEuropean Respiratory SocietyERJ Open Research2312-05412022-10-018410.1183/23120541.00121-202200121-2022Obstructive sleep apnoea-related respiratory events and desaturation severity are associated with the cardiac responseSalla Hietakoste0Tuomas Karhu1Saara Sillanmäki2Raquel Bailón3Thomas Penzel4Juha Töyräs5Timo Leppänen6Sami Myllymaa7Samu Kainulainen8 Dept of Applied Physics, University of Eastern Finland, Kuopio, Finland Dept of Applied Physics, University of Eastern Finland, Kuopio, Finland Diagnostic Imaging Center, Kuopio University Hospital, Kuopio, Finland Aragón Institute of Engineering Research, University of Zaragoza, Zaragoza, Spain Interdisciplinary Sleep Medicine Center, Charité-Universitätsmedizin Berlin, Berlin, Germany Dept of Applied Physics, University of Eastern Finland, Kuopio, Finland Dept of Applied Physics, University of Eastern Finland, Kuopio, Finland Dept of Applied Physics, University of Eastern Finland, Kuopio, Finland Dept of Applied Physics, University of Eastern Finland, Kuopio, Finland Background Obstructive sleep apnoea (OSA) causes, among other things, intermittent blood oxygen desaturations, increasing the sympathetic tone. Yet the effect of desaturations on heart rate variability (HRV), a simple and noninvasive method for assessing sympathovagal balance, has not been comprehensively studied. We aimed to study whether desaturation severity affects the immediate HRV. Methods We retrospectively analysed the electrocardiography signals in 5-min segments (n=39 132) recorded during clinical polysomnographies of 642 patients with suspected OSA. HRV parameters were calculated for each segment. The segments were pooled into severity groups based on the desaturation severity (i.e. the integrated area under the blood oxygen saturation curve) and the respiratory event rate within the segment. Covariate-adjusted regression analyses were performed to investigate possible confounding effects. Results With increasing respiratory event rate, the normalised high-frequency band power (HFNU) decreased from 0.517 to 0.364 (p<0.01), the normalised low-frequency band power (LFNU) increased from 0.483 to 0.636 (p<0.01) and the mean RR interval decreased from 915 to 869 ms (p<0.01). Similarly, with increasing desaturation severity, the HFNU decreased from 0.499 to 0.364 (p<0.01), the LFNU increased from 0.501 to 0.636 (p<0.01) and the mean RR interval decreased from 952 to 854 ms (p<0.01). Desaturation severity-related findings were confirmed by considering the confounding factors in the regression analyses. Conclusion The short-term HRV response differs based on the desaturation severity and the respiratory event rate in patients with suspected OSA. Therefore, a more detailed analysis of HRV and desaturation characteristics could enhance OSA severity estimation.http://openres.ersjournals.com/content/8/4/00121-2022.full |
| spellingShingle | Salla Hietakoste Tuomas Karhu Saara Sillanmäki Raquel Bailón Thomas Penzel Juha Töyräs Timo Leppänen Sami Myllymaa Samu Kainulainen Obstructive sleep apnoea-related respiratory events and desaturation severity are associated with the cardiac response ERJ Open Research |
| title | Obstructive sleep apnoea-related respiratory events and desaturation severity are associated with the cardiac response |
| title_full | Obstructive sleep apnoea-related respiratory events and desaturation severity are associated with the cardiac response |
| title_fullStr | Obstructive sleep apnoea-related respiratory events and desaturation severity are associated with the cardiac response |
| title_full_unstemmed | Obstructive sleep apnoea-related respiratory events and desaturation severity are associated with the cardiac response |
| title_short | Obstructive sleep apnoea-related respiratory events and desaturation severity are associated with the cardiac response |
| title_sort | obstructive sleep apnoea related respiratory events and desaturation severity are associated with the cardiac response |
| url | http://openres.ersjournals.com/content/8/4/00121-2022.full |
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