Chitotriosidase and Neopterin as Two Novel Potential Biomarkers for Advanced Stage and Survival Prediction in Gastric Cancer—A Pilot Study
Gastric cancer is the fifth type of neoplasia most frequently diagnosed and the fourth cause of death among other cancers. Prevalence is around two times higher for males than females. Chitotriosidase and neopterin are two molecular biomarkers with potential diagnostic and prognostic use in malignan...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/13/7/1362 |
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| author | Vlad-Ionuţ Nechita Nadim Al Hajjar Cristina Drugan Cristina-Sorina Cătană Emil Moiş Mihaela-Ancuţa Nechita Florin Graur |
| author_facet | Vlad-Ionuţ Nechita Nadim Al Hajjar Cristina Drugan Cristina-Sorina Cătană Emil Moiş Mihaela-Ancuţa Nechita Florin Graur |
| author_sort | Vlad-Ionuţ Nechita |
| collection | DOAJ |
| description | Gastric cancer is the fifth type of neoplasia most frequently diagnosed and the fourth cause of death among other cancers. Prevalence is around two times higher for males than females. Chitotriosidase and neopterin are two molecular biomarkers with potential diagnostic and prognostic use in malignant pathology. We conducted a longitudinal prospective cohort study on thirty-nine patients with gastric adenocarcinoma, with a male-to-female ratio of 1.78 and an average age of 64.3 ± 9.97 years. No statistically significant differences in biomarker levels at presentation were observed between curative-intent surgery (28 patients) and advanced cases, suited only for palliative procedures (11 patients). Biomarker values were not significantly different for the advanced T stage and the presence of metastasis (<i>p</i> > 0.05—Mann Whitney test). The patients that died in the first 30 days after surgery did not present significantly different values at baseline, in comparison with those that had longer survival times, though a significant cut-off value was observed for chitotriosidase activity at 310 nmol/mL/h [AUC (area under the curve) = 0.78; 95% CI (0.61–0.92)]. The cut-off values corresponding to death after the first year, tumor invasion, and metastasis were not statistically significant. In the COX multivariate model, neopterin did not validate itself as a prognostic biomarker, however, chitotriosidase activity before surgery was significantly associated with overall survival (HR = 1.0038, <i>p</i> = 0.03). We conclude that chitotriosidase may have the potential to improve the prognostic model for gastric adenocarcinoma. |
| first_indexed | 2024-03-11T05:40:16Z |
| format | Article |
| id | doaj.art-de6cda7f1b9940ca9d7f3292145e3c81 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-11T05:40:16Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-de6cda7f1b9940ca9d7f3292145e3c812023-11-17T16:31:33ZengMDPI AGDiagnostics2075-44182023-04-01137136210.3390/diagnostics13071362Chitotriosidase and Neopterin as Two Novel Potential Biomarkers for Advanced Stage and Survival Prediction in Gastric Cancer—A Pilot StudyVlad-Ionuţ Nechita0Nadim Al Hajjar1Cristina Drugan2Cristina-Sorina Cătană3Emil Moiş4Mihaela-Ancuţa Nechita5Florin Graur6Department of Medical Informatics and Biostatistics, “Iuliu Hațieganu” University of Medicine and Pharmacy, Louis Pasteur Str., No. 6, 400349 Cluj-Napoca, Romania“Octavian Fodor” Regional Institute of Gastroenterology and Hepatology, 010336 Cluj-Napoca, RomaniaDepartment of Medical Biochemistry, “Iuliu Hațieganu” University of Medicine and Pharmacy Cluj-Napoca, Louis Pasteur Str., No. 6, 400349 Cluj-Napoca, RomaniaDepartment of Medical Biochemistry, “Iuliu Hațieganu” University of Medicine and Pharmacy Cluj-Napoca, Louis Pasteur Str., No. 6, 400349 Cluj-Napoca, Romania“Octavian Fodor” Regional Institute of Gastroenterology and Hepatology, 010336 Cluj-Napoca, Romania“Ion Chiricuță” Oncology Institute, Republicii Str., No. 34–36, 400015 Cluj-Napoca, Romania“Octavian Fodor” Regional Institute of Gastroenterology and Hepatology, 010336 Cluj-Napoca, RomaniaGastric cancer is the fifth type of neoplasia most frequently diagnosed and the fourth cause of death among other cancers. Prevalence is around two times higher for males than females. Chitotriosidase and neopterin are two molecular biomarkers with potential diagnostic and prognostic use in malignant pathology. We conducted a longitudinal prospective cohort study on thirty-nine patients with gastric adenocarcinoma, with a male-to-female ratio of 1.78 and an average age of 64.3 ± 9.97 years. No statistically significant differences in biomarker levels at presentation were observed between curative-intent surgery (28 patients) and advanced cases, suited only for palliative procedures (11 patients). Biomarker values were not significantly different for the advanced T stage and the presence of metastasis (<i>p</i> > 0.05—Mann Whitney test). The patients that died in the first 30 days after surgery did not present significantly different values at baseline, in comparison with those that had longer survival times, though a significant cut-off value was observed for chitotriosidase activity at 310 nmol/mL/h [AUC (area under the curve) = 0.78; 95% CI (0.61–0.92)]. The cut-off values corresponding to death after the first year, tumor invasion, and metastasis were not statistically significant. In the COX multivariate model, neopterin did not validate itself as a prognostic biomarker, however, chitotriosidase activity before surgery was significantly associated with overall survival (HR = 1.0038, <i>p</i> = 0.03). We conclude that chitotriosidase may have the potential to improve the prognostic model for gastric adenocarcinoma.https://www.mdpi.com/2075-4418/13/7/1362gastric cancerneopterinchitotriosidasestadialisationresectabilitysurvival |
| spellingShingle | Vlad-Ionuţ Nechita Nadim Al Hajjar Cristina Drugan Cristina-Sorina Cătană Emil Moiş Mihaela-Ancuţa Nechita Florin Graur Chitotriosidase and Neopterin as Two Novel Potential Biomarkers for Advanced Stage and Survival Prediction in Gastric Cancer—A Pilot Study Diagnostics gastric cancer neopterin chitotriosidase stadialisation resectability survival |
| title | Chitotriosidase and Neopterin as Two Novel Potential Biomarkers for Advanced Stage and Survival Prediction in Gastric Cancer—A Pilot Study |
| title_full | Chitotriosidase and Neopterin as Two Novel Potential Biomarkers for Advanced Stage and Survival Prediction in Gastric Cancer—A Pilot Study |
| title_fullStr | Chitotriosidase and Neopterin as Two Novel Potential Biomarkers for Advanced Stage and Survival Prediction in Gastric Cancer—A Pilot Study |
| title_full_unstemmed | Chitotriosidase and Neopterin as Two Novel Potential Biomarkers for Advanced Stage and Survival Prediction in Gastric Cancer—A Pilot Study |
| title_short | Chitotriosidase and Neopterin as Two Novel Potential Biomarkers for Advanced Stage and Survival Prediction in Gastric Cancer—A Pilot Study |
| title_sort | chitotriosidase and neopterin as two novel potential biomarkers for advanced stage and survival prediction in gastric cancer a pilot study |
| topic | gastric cancer neopterin chitotriosidase stadialisation resectability survival |
| url | https://www.mdpi.com/2075-4418/13/7/1362 |
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