Gene Expression Profiling of Skeletal Muscle of Nursing Piglets
<p>To gain insight into the regulation mechanism associated with the rapid gain in skeletal muscle during neonatal period, gene expression profiles of skeletal muscle of nursing pigs was investigated using Affymetrix Porcine GeneChip. A total of 1094 transcripts were detected as differential e...
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| Format: | Article |
| Language: | English |
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Ivyspring International Publisher
2010-01-01
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| Series: | International Journal of Biological Sciences |
| Online Access: | http://www.biolsci.org/v06p0627.htm |
| _version_ | 1828296071112032256 |
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| author | Caode Jiang, Ping Shi, Shun Li, Ranran Dong, Jiawei Tian, Jin Wei, Shuang Luo |
| author_facet | Caode Jiang, Ping Shi, Shun Li, Ranran Dong, Jiawei Tian, Jin Wei, Shuang Luo |
| author_sort | Caode Jiang, Ping Shi, Shun Li, Ranran Dong, Jiawei Tian, Jin Wei, Shuang Luo |
| collection | DOAJ |
| description | <p>To gain insight into the regulation mechanism associated with the rapid gain in skeletal muscle during neonatal period, gene expression profiles of skeletal muscle of nursing pigs was investigated using Affymetrix Porcine GeneChip. A total of 1094 transcripts were detected as differential expression over time course tested (p<0.01, q<0.05). With combinative use of partitioning around medoid and hierarchical clustering, three clusters of transcripts with distinct temporal expression were defined. Gene functional categories and pathways, particularly involved in cell signaling, cell cycle, cell adhesion, ECM-receptor interaction, glycolysis, protein synthesis and degradation, and intracellular transport, were identified. Moreover, we showed 49 of the differentially expressed genes within published QTL regions or with marked deletion effects. Our study demonstrates previously uncharacterized changes in transcription accompanying early postnatal growth of skeletal muscle of pigs. It has highlighted potential cascades and important candidates for further investigation on controlling of postnatal muscle growth.</p> |
| first_indexed | 2024-04-13T12:05:27Z |
| format | Article |
| id | doaj.art-de6d1b9bd32d451da32d8a2520e710b1 |
| institution | Directory Open Access Journal |
| issn | 1449-2288 |
| language | English |
| last_indexed | 2024-04-13T12:05:27Z |
| publishDate | 2010-01-01 |
| publisher | Ivyspring International Publisher |
| record_format | Article |
| series | International Journal of Biological Sciences |
| spelling | doaj.art-de6d1b9bd32d451da32d8a2520e710b12022-12-22T02:47:40ZengIvyspring International PublisherInternational Journal of Biological Sciences1449-22882010-01-0167627638Gene Expression Profiling of Skeletal Muscle of Nursing PigletsCaode Jiang, Ping Shi, Shun Li, Ranran Dong, Jiawei Tian, Jin Wei, Shuang Luo<p>To gain insight into the regulation mechanism associated with the rapid gain in skeletal muscle during neonatal period, gene expression profiles of skeletal muscle of nursing pigs was investigated using Affymetrix Porcine GeneChip. A total of 1094 transcripts were detected as differential expression over time course tested (p<0.01, q<0.05). With combinative use of partitioning around medoid and hierarchical clustering, three clusters of transcripts with distinct temporal expression were defined. Gene functional categories and pathways, particularly involved in cell signaling, cell cycle, cell adhesion, ECM-receptor interaction, glycolysis, protein synthesis and degradation, and intracellular transport, were identified. Moreover, we showed 49 of the differentially expressed genes within published QTL regions or with marked deletion effects. Our study demonstrates previously uncharacterized changes in transcription accompanying early postnatal growth of skeletal muscle of pigs. It has highlighted potential cascades and important candidates for further investigation on controlling of postnatal muscle growth.</p>http://www.biolsci.org/v06p0627.htm |
| spellingShingle | Caode Jiang, Ping Shi, Shun Li, Ranran Dong, Jiawei Tian, Jin Wei, Shuang Luo Gene Expression Profiling of Skeletal Muscle of Nursing Piglets International Journal of Biological Sciences |
| title | Gene Expression Profiling of Skeletal Muscle of Nursing Piglets |
| title_full | Gene Expression Profiling of Skeletal Muscle of Nursing Piglets |
| title_fullStr | Gene Expression Profiling of Skeletal Muscle of Nursing Piglets |
| title_full_unstemmed | Gene Expression Profiling of Skeletal Muscle of Nursing Piglets |
| title_short | Gene Expression Profiling of Skeletal Muscle of Nursing Piglets |
| title_sort | gene expression profiling of skeletal muscle of nursing piglets |
| url | http://www.biolsci.org/v06p0627.htm |
| work_keys_str_mv | AT caodejiangpingshishunliranrandongjiaweitianjinweishuangluo geneexpressionprofilingofskeletalmuscleofnursingpiglets |