Quantum Dot Conjugated Magnetic Nanoparticles for Targeted Drug Delivery and Imaging
Nanotechnology is being increasingly applied for developing drug delivery options for specific treatments. Magnetic nanoparticles have drawn attention as drug delivery vehicles due to their stability, biocompatibility and ability to be non-invasively guided to desired target areas using magnetic fie...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2016-03-01
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| Series: | Nano Biomedicine and Engineering |
| Subjects: | |
| Online Access: | https://www.sciopen.com/article/10.5101/nbe.v8i1.p24-38 |
| _version_ | 1797673407838420992 |
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| author | Indu Venugopal Sebastian Pernal Taylor Fusinatto David Ashkenaz Andreas Linninger |
| author_facet | Indu Venugopal Sebastian Pernal Taylor Fusinatto David Ashkenaz Andreas Linninger |
| author_sort | Indu Venugopal |
| collection | DOAJ |
| description | Nanotechnology is being increasingly applied for developing drug delivery options for specific treatments. Magnetic nanoparticles have drawn attention as drug delivery vehicles due to their stability, biocompatibility and ability to be non-invasively guided to desired target areas using magnetic fields. In this paper, we describe a new delivery vehicle for magnetic drug targeting. In magnetic drug targeting, drug functionalized magnetic nanoparticles are guided and localized at specific sites using external magnetic fields. Magnetic nanoparticles act as contrast agents for magnetic resonance imaging. However, it cannot be visualized via this technique during drug delivery. This is between magnetic fields used for imaging and delivery can interference with each other. Our laboratory has synthesized a magnetic drug targeting vehicle conjugated with quantum dots that can be imaged during the drug delivery process with in vivo imaging techniques such as fluorescence molecular tomography. These nanocomposites can be used as drug delivery vehicles for the central nervous system, where drug targeting is especially difficult and minimizing side effects is critical. |
| first_indexed | 2024-03-11T21:45:02Z |
| format | Article |
| id | doaj.art-de6d2001603e4b3bbeba4f63327462e0 |
| institution | Directory Open Access Journal |
| issn | 2150-5578 |
| language | English |
| last_indexed | 2024-03-11T21:45:02Z |
| publishDate | 2016-03-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Nano Biomedicine and Engineering |
| spelling | doaj.art-de6d2001603e4b3bbeba4f63327462e02023-09-26T10:54:24ZengTsinghua University PressNano Biomedicine and Engineering2150-55782016-03-0181243810.5101/nbe.v8i1.p24-38Quantum Dot Conjugated Magnetic Nanoparticles for Targeted Drug Delivery and ImagingIndu Venugopal0Sebastian Pernal1Taylor Fusinatto2David Ashkenaz3Andreas Linninger4University of Illinois at Chicago, Department of Bioengineering, Laboratory for Product and Process DesignUniversity of Illinois at Chicago, Department of Bioengineering, Laboratory for Product and Process DesignUniversity of Illinois at Chicago, Department of Bioengineering, Laboratory for Product and Process DesignUniversity of Illinois at Chicago, Department of Bioengineering, Laboratory for Product and Process DesignUniversity of Illinois at Chicago, Department of Bioengineering, Laboratory for Product and Process DesignNanotechnology is being increasingly applied for developing drug delivery options for specific treatments. Magnetic nanoparticles have drawn attention as drug delivery vehicles due to their stability, biocompatibility and ability to be non-invasively guided to desired target areas using magnetic fields. In this paper, we describe a new delivery vehicle for magnetic drug targeting. In magnetic drug targeting, drug functionalized magnetic nanoparticles are guided and localized at specific sites using external magnetic fields. Magnetic nanoparticles act as contrast agents for magnetic resonance imaging. However, it cannot be visualized via this technique during drug delivery. This is between magnetic fields used for imaging and delivery can interference with each other. Our laboratory has synthesized a magnetic drug targeting vehicle conjugated with quantum dots that can be imaged during the drug delivery process with in vivo imaging techniques such as fluorescence molecular tomography. These nanocomposites can be used as drug delivery vehicles for the central nervous system, where drug targeting is especially difficult and minimizing side effects is critical.https://www.sciopen.com/article/10.5101/nbe.v8i1.p24-38fluorescent nanoparticlesmagnetic nanoparticlesmagnetic drug targetingdrug delivery |
| spellingShingle | Indu Venugopal Sebastian Pernal Taylor Fusinatto David Ashkenaz Andreas Linninger Quantum Dot Conjugated Magnetic Nanoparticles for Targeted Drug Delivery and Imaging Nano Biomedicine and Engineering fluorescent nanoparticles magnetic nanoparticles magnetic drug targeting drug delivery |
| title | Quantum Dot Conjugated Magnetic Nanoparticles for Targeted Drug Delivery and Imaging |
| title_full | Quantum Dot Conjugated Magnetic Nanoparticles for Targeted Drug Delivery and Imaging |
| title_fullStr | Quantum Dot Conjugated Magnetic Nanoparticles for Targeted Drug Delivery and Imaging |
| title_full_unstemmed | Quantum Dot Conjugated Magnetic Nanoparticles for Targeted Drug Delivery and Imaging |
| title_short | Quantum Dot Conjugated Magnetic Nanoparticles for Targeted Drug Delivery and Imaging |
| title_sort | quantum dot conjugated magnetic nanoparticles for targeted drug delivery and imaging |
| topic | fluorescent nanoparticles magnetic nanoparticles magnetic drug targeting drug delivery |
| url | https://www.sciopen.com/article/10.5101/nbe.v8i1.p24-38 |
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