Key role of histological and PCR studies in the differential diagnosis of heart valve disease in Takayasu’s arteritis, infective endocarditis and myxomatous degeneration
Aortic valve lesion is a common cardiopathy, which may have very diverse causes, from degenerative, congenital and infectious diseases to autoimmune conditions. We present a rare case of Takayasu arteritis and severe heart lesion due to the myxomatous degeneration of the aortic and mitral valve cusp...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Peoples’ Friendship University of Russia (RUDN University)
2023-06-01
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| Series: | RUDN Journal of Medicine |
| Subjects: | |
| Online Access: | https://journals.rudn.ru/medicine/article/viewFile/35097/22179 |
| _version_ | 1797789109519908864 |
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| author | Alexandra S. Pisaryuk Elizaveta O. Kotova Alexandra Yu. Moiseeva Elvira A. Domonova Natalia S. Tsimbalist Imad A. Meray Ayten F. Safarova Tatiana G. Bogdanova Natalia E. Tolokonnikova Zhanna D. Kobalava |
| author_facet | Alexandra S. Pisaryuk Elizaveta O. Kotova Alexandra Yu. Moiseeva Elvira A. Domonova Natalia S. Tsimbalist Imad A. Meray Ayten F. Safarova Tatiana G. Bogdanova Natalia E. Tolokonnikova Zhanna D. Kobalava |
| author_sort | Alexandra S. Pisaryuk |
| collection | DOAJ |
| description | Aortic valve lesion is a common cardiopathy, which may have very diverse causes, from degenerative, congenital and infectious diseases to autoimmune conditions. We present a rare case of Takayasu arteritis and severe heart lesion due to the myxomatous degeneration of the aortic and mitral valve cusps associated with the development of infectious endocarditis (IE) complicated by abscess, fistula, valve perforation and recurrent acute decompensated heart failure in a young female patient. A combined use of histopathological and PCR analyses of valve tissues was critically important for differential diagnosis of the valve lesions, as it made it possible to identify the true cause of the structural cardiopathy associated with myxomatous degeneration and a prior IE. The presence of Takayasu arteritis has played an indirect though apparently decisive role by creating conditions for the development of immunosuppression and determining the disease severity and progression rate. |
| first_indexed | 2024-03-13T01:46:06Z |
| format | Article |
| id | doaj.art-de6e63e670014d00961d8e616ea8d461 |
| institution | Directory Open Access Journal |
| issn | 2313-0245 2313-0261 |
| language | English |
| last_indexed | 2024-03-13T01:46:06Z |
| publishDate | 2023-06-01 |
| publisher | Peoples’ Friendship University of Russia (RUDN University) |
| record_format | Article |
| series | RUDN Journal of Medicine |
| spelling | doaj.art-de6e63e670014d00961d8e616ea8d4612023-07-03T08:32:29ZengPeoples’ Friendship University of Russia (RUDN University)RUDN Journal of Medicine2313-02452313-02612023-06-0127219520610.22363/2313-0245-2023-27-2-195-20621111Key role of histological and PCR studies in the differential diagnosis of heart valve disease in Takayasu’s arteritis, infective endocarditis and myxomatous degenerationAlexandra S. Pisaryuk0https://orcid.org/0000-0003-4103-4322Elizaveta O. Kotova1https://orcid.org/0000-0002-9643-5089Alexandra Yu. Moiseeva2https://orcid.org/0000-0003-0718-5258Elvira A. Domonova3Natalia S. Tsimbalist4https://orcid.org/0000-0001-8719-1169Imad A. Meray5https://orcid.org/0000-0001-6818-8845Ayten F. Safarova6https://orcid.org/0000-0003-2412-5986Tatiana G. Bogdanova7https://orcid.org/0000-0001-5485-8633Natalia E. Tolokonnikova8https://orcid.org/0000-0002-4769-1983Zhanna D. Kobalava9https://orcid.org/0000-0002-5873-1768City Clinical Hospital named after V.V. VinogradovCity Clinical Hospital named after V.V. VinogradovCity Clinical Hospital named after V.V. VinogradovCentral Research Institute of EpidemiologyCity Clinical Hospital named after V.V. VinogradovCity Clinical Hospital named after V.V. VinogradovCity Clinical Hospital named after V.V. VinogradovCity Clinical Hospital named after V.V. VinogradovCity Clinical Hospital named after V.V. VinogradovCity Clinical Hospital named after V.V. VinogradovAortic valve lesion is a common cardiopathy, which may have very diverse causes, from degenerative, congenital and infectious diseases to autoimmune conditions. We present a rare case of Takayasu arteritis and severe heart lesion due to the myxomatous degeneration of the aortic and mitral valve cusps associated with the development of infectious endocarditis (IE) complicated by abscess, fistula, valve perforation and recurrent acute decompensated heart failure in a young female patient. A combined use of histopathological and PCR analyses of valve tissues was critically important for differential diagnosis of the valve lesions, as it made it possible to identify the true cause of the structural cardiopathy associated with myxomatous degeneration and a prior IE. The presence of Takayasu arteritis has played an indirect though apparently decisive role by creating conditions for the development of immunosuppression and determining the disease severity and progression rate.https://journals.rudn.ru/medicine/article/viewFile/35097/22179infectious endocarditistakayasu arteritisaortic insufficiencypcr-testmyxomatous degenerationhistopathologic examinationduke criteria |
| spellingShingle | Alexandra S. Pisaryuk Elizaveta O. Kotova Alexandra Yu. Moiseeva Elvira A. Domonova Natalia S. Tsimbalist Imad A. Meray Ayten F. Safarova Tatiana G. Bogdanova Natalia E. Tolokonnikova Zhanna D. Kobalava Key role of histological and PCR studies in the differential diagnosis of heart valve disease in Takayasu’s arteritis, infective endocarditis and myxomatous degeneration RUDN Journal of Medicine infectious endocarditis takayasu arteritis aortic insufficiency pcr-test myxomatous degeneration histopathologic examination duke criteria |
| title | Key role of histological and PCR studies in the differential diagnosis of heart valve disease in Takayasu’s arteritis, infective endocarditis and myxomatous degeneration |
| title_full | Key role of histological and PCR studies in the differential diagnosis of heart valve disease in Takayasu’s arteritis, infective endocarditis and myxomatous degeneration |
| title_fullStr | Key role of histological and PCR studies in the differential diagnosis of heart valve disease in Takayasu’s arteritis, infective endocarditis and myxomatous degeneration |
| title_full_unstemmed | Key role of histological and PCR studies in the differential diagnosis of heart valve disease in Takayasu’s arteritis, infective endocarditis and myxomatous degeneration |
| title_short | Key role of histological and PCR studies in the differential diagnosis of heart valve disease in Takayasu’s arteritis, infective endocarditis and myxomatous degeneration |
| title_sort | key role of histological and pcr studies in the differential diagnosis of heart valve disease in takayasu s arteritis infective endocarditis and myxomatous degeneration |
| topic | infectious endocarditis takayasu arteritis aortic insufficiency pcr-test myxomatous degeneration histopathologic examination duke criteria |
| url | https://journals.rudn.ru/medicine/article/viewFile/35097/22179 |
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