Incomplete recovery of the fecal flora of hematological patients with neutropenia and repeated fluoroquinolone prophylaxis
Yong Chong,1 Shinji Shimoda,1 Noriko Miyake,1 Takatoshi Aoki,2 Yoshikiyo Ito,3 Tomohiko Kamimura,2 Nobuyuki Shimono4 1Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, 2Department of Blood and Marrow Transplantation, Hara-Sanshin Hospital, Fukuoka...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2017-06-01
|
| Series: | Infection and Drug Resistance |
| Subjects: | |
| Online Access: | https://www.dovepress.com/incomplete-recovery-of-the-fecal-flora-of-hematological-patients-with--peer-reviewed-article-IDR |
| _version_ | 1811280143457452032 |
|---|---|
| author | Chong Y Shimoda S Miyake N Aoki T Ito Y Kamimura T Shimono N |
| author_facet | Chong Y Shimoda S Miyake N Aoki T Ito Y Kamimura T Shimono N |
| author_sort | Chong Y |
| collection | DOAJ |
| description | Yong Chong,1 Shinji Shimoda,1 Noriko Miyake,1 Takatoshi Aoki,2 Yoshikiyo Ito,3 Tomohiko Kamimura,2 Nobuyuki Shimono4 1Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, 2Department of Blood and Marrow Transplantation, Hara-Sanshin Hospital, Fukuoka, 3Department of Internal Medicine, Kyushu University Beppu Hospital, Beppu, 4Center for the Study of Global Infection, Kyushu University Hospital, Fukuoka, Japan Background: Routine fluoroquinolone prophylaxis in neutropenic patients with hematological malignancies is still controversial, because of antibiotic resistance concerns. The recovery of the fecal microbiota to the initial composition in patients receiving multiple courses of quinolone prophylaxis and repeated chemotherapy has not been evaluated. Methods: We prospectively examined the changes in the fecal bacterial composition before and after levofloxacin prophylaxis. A sequential observation of bacterial resistance in patients receiving multiple prophylactic courses was also conducted. Results: In this trial, 68 cases, including (35 with the first course and 33 with the second and subsequent courses) were registered. The disappearance of quinolone-susceptible (QS) Enterobacteriaceae and dominant emergence of quinolone-resistant (QR) coagulase negative staphylococci (CNS) and QR Enterococci were observed after the first prophylaxis. The detection of QS Enterobacteriaceae was recovered before the second and subsequent courses to a level of the initial composition (28/35 samples, 80.0% before the first course vs 23/33 samples, 69.7% before the second and subsequent courses, P=0.41). In contrast, the detection rate of QR CNS and Enterococci significantly increased at the second and subsequent courses, even before prophylaxis (8/35 samples, 22.9% before the first course vs 20/33 samples, 60.6% before the second and subsequent courses, P=0.003). The incomplete recovery of the initial bacterial composition was associated with a prophylactic interval of within 30 days. Of the patients receiving multiple prophylactic courses, six had QR Escherichia coli, including extended-spectrum β-lactamase (ESBL) producers, at the first course, and four (66.3%) of the six patients had persistent detection of QR E. coli at the second course. Conclusion: In patients receiving multiple courses of prophylactic quinolone, along with a common chemotherapy schedule, newly emergent resistant bacteria could be frequently persistent in their fecal flora. Keywords: febrile neutropenia, prophylaxis, fluoroquinolone, antibiotic resistance, fecal flora, chemotherapy |
| first_indexed | 2024-04-13T01:08:14Z |
| format | Article |
| id | doaj.art-de6e74044f1d4a84837e970dccc89d0c |
| institution | Directory Open Access Journal |
| issn | 1178-6973 |
| language | English |
| last_indexed | 2024-04-13T01:08:14Z |
| publishDate | 2017-06-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Infection and Drug Resistance |
| spelling | doaj.art-de6e74044f1d4a84837e970dccc89d0c2022-12-22T03:09:16ZengDove Medical PressInfection and Drug Resistance1178-69732017-06-01Volume 1019319933456Incomplete recovery of the fecal flora of hematological patients with neutropenia and repeated fluoroquinolone prophylaxisChong YShimoda SMiyake NAoki TIto YKamimura TShimono NYong Chong,1 Shinji Shimoda,1 Noriko Miyake,1 Takatoshi Aoki,2 Yoshikiyo Ito,3 Tomohiko Kamimura,2 Nobuyuki Shimono4 1Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, 2Department of Blood and Marrow Transplantation, Hara-Sanshin Hospital, Fukuoka, 3Department of Internal Medicine, Kyushu University Beppu Hospital, Beppu, 4Center for the Study of Global Infection, Kyushu University Hospital, Fukuoka, Japan Background: Routine fluoroquinolone prophylaxis in neutropenic patients with hematological malignancies is still controversial, because of antibiotic resistance concerns. The recovery of the fecal microbiota to the initial composition in patients receiving multiple courses of quinolone prophylaxis and repeated chemotherapy has not been evaluated. Methods: We prospectively examined the changes in the fecal bacterial composition before and after levofloxacin prophylaxis. A sequential observation of bacterial resistance in patients receiving multiple prophylactic courses was also conducted. Results: In this trial, 68 cases, including (35 with the first course and 33 with the second and subsequent courses) were registered. The disappearance of quinolone-susceptible (QS) Enterobacteriaceae and dominant emergence of quinolone-resistant (QR) coagulase negative staphylococci (CNS) and QR Enterococci were observed after the first prophylaxis. The detection of QS Enterobacteriaceae was recovered before the second and subsequent courses to a level of the initial composition (28/35 samples, 80.0% before the first course vs 23/33 samples, 69.7% before the second and subsequent courses, P=0.41). In contrast, the detection rate of QR CNS and Enterococci significantly increased at the second and subsequent courses, even before prophylaxis (8/35 samples, 22.9% before the first course vs 20/33 samples, 60.6% before the second and subsequent courses, P=0.003). The incomplete recovery of the initial bacterial composition was associated with a prophylactic interval of within 30 days. Of the patients receiving multiple prophylactic courses, six had QR Escherichia coli, including extended-spectrum β-lactamase (ESBL) producers, at the first course, and four (66.3%) of the six patients had persistent detection of QR E. coli at the second course. Conclusion: In patients receiving multiple courses of prophylactic quinolone, along with a common chemotherapy schedule, newly emergent resistant bacteria could be frequently persistent in their fecal flora. Keywords: febrile neutropenia, prophylaxis, fluoroquinolone, antibiotic resistance, fecal flora, chemotherapyhttps://www.dovepress.com/incomplete-recovery-of-the-fecal-flora-of-hematological-patients-with--peer-reviewed-article-IDRfebrile neutropeniaprophylaxisfluoroquinoloneantibiotic resistancefecal flora |
| spellingShingle | Chong Y Shimoda S Miyake N Aoki T Ito Y Kamimura T Shimono N Incomplete recovery of the fecal flora of hematological patients with neutropenia and repeated fluoroquinolone prophylaxis Infection and Drug Resistance febrile neutropenia prophylaxis fluoroquinolone antibiotic resistance fecal flora |
| title | Incomplete recovery of the fecal flora of hematological patients with neutropenia and repeated fluoroquinolone prophylaxis |
| title_full | Incomplete recovery of the fecal flora of hematological patients with neutropenia and repeated fluoroquinolone prophylaxis |
| title_fullStr | Incomplete recovery of the fecal flora of hematological patients with neutropenia and repeated fluoroquinolone prophylaxis |
| title_full_unstemmed | Incomplete recovery of the fecal flora of hematological patients with neutropenia and repeated fluoroquinolone prophylaxis |
| title_short | Incomplete recovery of the fecal flora of hematological patients with neutropenia and repeated fluoroquinolone prophylaxis |
| title_sort | incomplete recovery of the fecal flora of hematological patients with neutropenia and repeated fluoroquinolone prophylaxis |
| topic | febrile neutropenia prophylaxis fluoroquinolone antibiotic resistance fecal flora |
| url | https://www.dovepress.com/incomplete-recovery-of-the-fecal-flora-of-hematological-patients-with--peer-reviewed-article-IDR |
| work_keys_str_mv | AT chongy incompleterecoveryofthefecalfloraofhematologicalpatientswithneutropeniaandrepeatedfluoroquinoloneprophylaxis AT shimodas incompleterecoveryofthefecalfloraofhematologicalpatientswithneutropeniaandrepeatedfluoroquinoloneprophylaxis AT miyaken incompleterecoveryofthefecalfloraofhematologicalpatientswithneutropeniaandrepeatedfluoroquinoloneprophylaxis AT aokit incompleterecoveryofthefecalfloraofhematologicalpatientswithneutropeniaandrepeatedfluoroquinoloneprophylaxis AT itoy incompleterecoveryofthefecalfloraofhematologicalpatientswithneutropeniaandrepeatedfluoroquinoloneprophylaxis AT kamimurat incompleterecoveryofthefecalfloraofhematologicalpatientswithneutropeniaandrepeatedfluoroquinoloneprophylaxis AT shimonon incompleterecoveryofthefecalfloraofhematologicalpatientswithneutropeniaandrepeatedfluoroquinoloneprophylaxis |