Biomimetic Nanomaterials Triggered Ferroptosis for Cancer Theranostics
Ferroptosis, as a recently discovered non-apoptotic programmed cell death with an iron-dependent form, has attracted great attention in the field of cancer nanomedicine. However, many ferroptosis-related nano-inducers encountered unexpected limitations such as immune exposure, low circulation time,...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-11-01
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| Series: | Frontiers in Chemistry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fchem.2021.768248/full |
| _version_ | 1818844449334099968 |
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| author | Xinyu Zhang Yanling Ma Jipeng Wan Jia Yuan Diqing Wang Weiyi Wang Xiao Sun Qingwei Meng |
| author_facet | Xinyu Zhang Yanling Ma Jipeng Wan Jia Yuan Diqing Wang Weiyi Wang Xiao Sun Qingwei Meng |
| author_sort | Xinyu Zhang |
| collection | DOAJ |
| description | Ferroptosis, as a recently discovered non-apoptotic programmed cell death with an iron-dependent form, has attracted great attention in the field of cancer nanomedicine. However, many ferroptosis-related nano-inducers encountered unexpected limitations such as immune exposure, low circulation time, and ineffective tumor targeting. Biomimetic nanomaterials possess some unique physicochemical properties which can achieve immune escape and effective tumor targeting. Especially, certain components of biomimetic nanomaterials can further enhance ferroptosis. Therefore, this review will provide a comprehensive overview on recent developments of biomimetic nanomaterials in ferroptosis-related cancer nanomedicine. First, the definition and character of ferroptosis and its current applications associated with chemotherapy, radiotherapy, and immunotherapy for enhancing cancer theranostics were briefly discussed. Subsequently, the advantages and limitations of some representative biomimetic nanomedicines, including biomembranes, proteins, amino acids, polyunsaturated fatty acids, and biomineralization-based ferroptosis nano-inducers, were further spotlighted. This review would therefore help the spectrum of advanced and novice researchers who are interested in this area to quickly zoom in the essential information and glean some provoking ideas to advance this subfield in cancer nanomedicine. |
| first_indexed | 2024-12-19T05:13:56Z |
| format | Article |
| id | doaj.art-de6ebf63e3e4447faba09af47c5a086b |
| institution | Directory Open Access Journal |
| issn | 2296-2646 |
| language | English |
| last_indexed | 2024-12-19T05:13:56Z |
| publishDate | 2021-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemistry |
| spelling | doaj.art-de6ebf63e3e4447faba09af47c5a086b2022-12-21T20:34:44ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462021-11-01910.3389/fchem.2021.768248768248Biomimetic Nanomaterials Triggered Ferroptosis for Cancer TheranosticsXinyu Zhang0Yanling Ma1Jipeng Wan2Jia Yuan3Diqing Wang4Weiyi Wang5Xiao Sun6Qingwei Meng7Department of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, ChinaDepartment of Chemical and Biomolecular Engineering, National University of Singapore, Singapore, SingaporeSchool of Chemistry and Pharmaceutical Engineering, Institute of Optical Functional Materials for Biomedical Imaging, Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, ChinaSchool of Chemistry and Pharmaceutical Engineering, Institute of Optical Functional Materials for Biomedical Imaging, Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, ChinaSchool of Chemistry and Pharmaceutical Engineering, Institute of Optical Functional Materials for Biomedical Imaging, Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, ChinaSchool of Chemistry and Pharmaceutical Engineering, Institute of Optical Functional Materials for Biomedical Imaging, Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, ChinaSchool of Chemistry and Pharmaceutical Engineering, Institute of Optical Functional Materials for Biomedical Imaging, Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, ChinaDepartment of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, ChinaFerroptosis, as a recently discovered non-apoptotic programmed cell death with an iron-dependent form, has attracted great attention in the field of cancer nanomedicine. However, many ferroptosis-related nano-inducers encountered unexpected limitations such as immune exposure, low circulation time, and ineffective tumor targeting. Biomimetic nanomaterials possess some unique physicochemical properties which can achieve immune escape and effective tumor targeting. Especially, certain components of biomimetic nanomaterials can further enhance ferroptosis. Therefore, this review will provide a comprehensive overview on recent developments of biomimetic nanomaterials in ferroptosis-related cancer nanomedicine. First, the definition and character of ferroptosis and its current applications associated with chemotherapy, radiotherapy, and immunotherapy for enhancing cancer theranostics were briefly discussed. Subsequently, the advantages and limitations of some representative biomimetic nanomedicines, including biomembranes, proteins, amino acids, polyunsaturated fatty acids, and biomineralization-based ferroptosis nano-inducers, were further spotlighted. This review would therefore help the spectrum of advanced and novice researchers who are interested in this area to quickly zoom in the essential information and glean some provoking ideas to advance this subfield in cancer nanomedicine.https://www.frontiersin.org/articles/10.3389/fchem.2021.768248/fullbiomimetic modificationnanomedicineferroptosisdiagnosiscancer therapy |
| spellingShingle | Xinyu Zhang Yanling Ma Jipeng Wan Jia Yuan Diqing Wang Weiyi Wang Xiao Sun Qingwei Meng Biomimetic Nanomaterials Triggered Ferroptosis for Cancer Theranostics Frontiers in Chemistry biomimetic modification nanomedicine ferroptosis diagnosis cancer therapy |
| title | Biomimetic Nanomaterials Triggered Ferroptosis for Cancer Theranostics |
| title_full | Biomimetic Nanomaterials Triggered Ferroptosis for Cancer Theranostics |
| title_fullStr | Biomimetic Nanomaterials Triggered Ferroptosis for Cancer Theranostics |
| title_full_unstemmed | Biomimetic Nanomaterials Triggered Ferroptosis for Cancer Theranostics |
| title_short | Biomimetic Nanomaterials Triggered Ferroptosis for Cancer Theranostics |
| title_sort | biomimetic nanomaterials triggered ferroptosis for cancer theranostics |
| topic | biomimetic modification nanomedicine ferroptosis diagnosis cancer therapy |
| url | https://www.frontiersin.org/articles/10.3389/fchem.2021.768248/full |
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