Gray matter reduction is associated with cognitive dysfunction in depressed patients comorbid with subclinical hypothyroidism
IntroductionTo explore the association between regional gray matter volume (GMV) and cognitive impairments and ascertain whether the regional brain alterations related to cognitive impairments occur in major depressive disorder (MDD) patients with comorbid subclinical hypothyroidism (SHypo).MethodsW...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1106792/full |
| _version_ | 1811169391608332288 |
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| author | Shuai Zhao Shuai Zhao Shuai Zhao Shuai Zhao Shuai Zhao Yishan Du Yu Zhang Xiaoqin Wang Yi Xia Hao Sun Yinghong Huang Haowen Zou Xumiao Wang Zhilu Chen Hongliang Zhou Rui Yan Hao Tang Qing Lu Qing Lu Zhijian Yao Zhijian Yao |
| author_facet | Shuai Zhao Shuai Zhao Shuai Zhao Shuai Zhao Shuai Zhao Yishan Du Yu Zhang Xiaoqin Wang Yi Xia Hao Sun Yinghong Huang Haowen Zou Xumiao Wang Zhilu Chen Hongliang Zhou Rui Yan Hao Tang Qing Lu Qing Lu Zhijian Yao Zhijian Yao |
| author_sort | Shuai Zhao |
| collection | DOAJ |
| description | IntroductionTo explore the association between regional gray matter volume (GMV) and cognitive impairments and ascertain whether the regional brain alterations related to cognitive impairments occur in major depressive disorder (MDD) patients with comorbid subclinical hypothyroidism (SHypo).MethodsWe enrolled 32 MDD patients, 32 MDD patients with comorbid SHypo, and 32 normal controls and subjected them to thyroid function tests, neurocognitive tests, and magnetic resonance imaging (MRI). Using voxel-based morphometry (VBM) analysis, we examined the pattern of gray matter (GM) in these participants. We also used ANOVA to detect group differences and partial correlation to explore the potential association between GMV alterations and cognitive tests in comorbid patients.ResultsThe comorbid patients exhibited significantly smaller GMV in the right middle frontal gyrus (MFG) than the non-comorbid group. Furthermore, the partial correlation analysis showed that GMV of the right MFG was associated with poor executive function (EF) performance in comorbid patients.ConclusionThese findings provide valuable insight into the relationship between the alteration of GMV and cognitive dysfunction of MDD patients with comorbid SHypo. |
| first_indexed | 2024-04-10T16:41:34Z |
| format | Article |
| id | doaj.art-de7136ccc76e48f6b9726a09bbac73db |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-10T16:41:34Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-de7136ccc76e48f6b9726a09bbac73db2023-02-08T06:54:07ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652023-02-011510.3389/fnagi.2023.11067921106792Gray matter reduction is associated with cognitive dysfunction in depressed patients comorbid with subclinical hypothyroidismShuai Zhao0Shuai Zhao1Shuai Zhao2Shuai Zhao3Shuai Zhao4Yishan Du5Yu Zhang6Xiaoqin Wang7Yi Xia8Hao Sun9Yinghong Huang10Haowen Zou11Xumiao Wang12Zhilu Chen13Hongliang Zhou14Rui Yan15Hao Tang16Qing Lu17Qing Lu18Zhijian Yao19Zhijian Yao20Department of Psychiatry, The Affiliated Psychological Hospital of Anhui Medical University, Hefei, ChinaHefei Fourth People’s Hospital, Hefei, ChinaAnhui Mental Health Center, Hefei, ChinaAnhui Clinical Research Center for Mental Disorders, Hefei, ChinaDepartment of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, ChinaNanjing Brain Hospital, Medical School of Nanjing University, Nanjing, ChinaDepartment of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, ChinaSchool of Biological Sciences & Medical Engineering, Southeast University, Nanjing, ChinaChild Development and Learning Science, Key Laboratory of Ministry of Education, Nanjing, ChinaDepartment of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, ChinaNanjing Brain Hospital, Medical School of Nanjing University, Nanjing, ChinaIntroductionTo explore the association between regional gray matter volume (GMV) and cognitive impairments and ascertain whether the regional brain alterations related to cognitive impairments occur in major depressive disorder (MDD) patients with comorbid subclinical hypothyroidism (SHypo).MethodsWe enrolled 32 MDD patients, 32 MDD patients with comorbid SHypo, and 32 normal controls and subjected them to thyroid function tests, neurocognitive tests, and magnetic resonance imaging (MRI). Using voxel-based morphometry (VBM) analysis, we examined the pattern of gray matter (GM) in these participants. We also used ANOVA to detect group differences and partial correlation to explore the potential association between GMV alterations and cognitive tests in comorbid patients.ResultsThe comorbid patients exhibited significantly smaller GMV in the right middle frontal gyrus (MFG) than the non-comorbid group. Furthermore, the partial correlation analysis showed that GMV of the right MFG was associated with poor executive function (EF) performance in comorbid patients.ConclusionThese findings provide valuable insight into the relationship between the alteration of GMV and cognitive dysfunction of MDD patients with comorbid SHypo.https://www.frontiersin.org/articles/10.3389/fnagi.2023.1106792/fullgray mattercognitive declineMDDsubclinical hypothyroidismfMRI |
| spellingShingle | Shuai Zhao Shuai Zhao Shuai Zhao Shuai Zhao Shuai Zhao Yishan Du Yu Zhang Xiaoqin Wang Yi Xia Hao Sun Yinghong Huang Haowen Zou Xumiao Wang Zhilu Chen Hongliang Zhou Rui Yan Hao Tang Qing Lu Qing Lu Zhijian Yao Zhijian Yao Gray matter reduction is associated with cognitive dysfunction in depressed patients comorbid with subclinical hypothyroidism Frontiers in Aging Neuroscience gray matter cognitive decline MDD subclinical hypothyroidism fMRI |
| title | Gray matter reduction is associated with cognitive dysfunction in depressed patients comorbid with subclinical hypothyroidism |
| title_full | Gray matter reduction is associated with cognitive dysfunction in depressed patients comorbid with subclinical hypothyroidism |
| title_fullStr | Gray matter reduction is associated with cognitive dysfunction in depressed patients comorbid with subclinical hypothyroidism |
| title_full_unstemmed | Gray matter reduction is associated with cognitive dysfunction in depressed patients comorbid with subclinical hypothyroidism |
| title_short | Gray matter reduction is associated with cognitive dysfunction in depressed patients comorbid with subclinical hypothyroidism |
| title_sort | gray matter reduction is associated with cognitive dysfunction in depressed patients comorbid with subclinical hypothyroidism |
| topic | gray matter cognitive decline MDD subclinical hypothyroidism fMRI |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1106792/full |
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