Dexmedetomidine provides better hemodynamic stability compared to clonidine in spine surgery
Introduction: Spine surgery presents a number of challenges to the anesthesiologist. The a2 adrenergic agonist drugs are commonly used in such cases to provide hemodynamic and sympathoadrenal stability. Dexmedetomidine (DEX) is one of the most potent and highly selective a2-adrenergic receptor agoni...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2018-01-01
|
| Series: | Bali Journal of Anesthesiology |
| Subjects: | |
| Online Access: | http://www.bjoaonline.com/article.asp?issn=2549-2276;year=2018;volume=2;issue=3;spage=90;epage=94;aulast=Suyasa;type=0 |
| _version_ | 1819145500123725824 |
|---|---|
| author | I Ketut Suyasa Christopher Ryalino Ni Putu Novita Pradnyani |
| author_facet | I Ketut Suyasa Christopher Ryalino Ni Putu Novita Pradnyani |
| author_sort | I Ketut Suyasa |
| collection | DOAJ |
| description | Introduction: Spine surgery presents a number of challenges to the anesthesiologist. The a2 adrenergic agonist drugs are commonly used in such cases to provide hemodynamic and sympathoadrenal stability. Dexmedetomidine (DEX) is one of the most potent and highly selective a2-adrenergic receptor agonists. Another a2 adrenergic agonist drug that is used widely is clonidine. The study aims to compare both drugs in terms of hemodynamic stability in spine surgeries.
Patients and Methods: 30 patients underwent spinal surgery were classified into one of the following group: DEX group (received DEX 1 mcg/kg in 10 minutes followed by 0.5 mcg/kg/hour during the course of the surgery) or CLO group (received clonidine 1 mcg/kg in 10 minutes followed by 1 mcg/kg/hour during surgery), by consecutive sampling. All other treatments and medications were similar in both groups. The systolic and diastolic blood pressure, mean arterial pressure, and heart rate were recorded every 5 minutes. Data was then analyzed by SPSS.
Result: The patients in the DEX group had a better mean arterial pressure (p=0.002) and heart rate (p=0.018) stability compared to those in the CLO group.
Conclusion: The administration of dexmedetomidine provides a better hemodynamic stability compared to clonidine in patients underwent spinal surgery. |
| first_indexed | 2024-12-22T12:59:01Z |
| format | Article |
| id | doaj.art-de71fcee0a4b45f488675b68b1f0ea47 |
| institution | Directory Open Access Journal |
| issn | 2549-2276 |
| language | English |
| last_indexed | 2024-12-22T12:59:01Z |
| publishDate | 2018-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Bali Journal of Anesthesiology |
| spelling | doaj.art-de71fcee0a4b45f488675b68b1f0ea472022-12-21T18:25:02ZengWolters Kluwer Medknow PublicationsBali Journal of Anesthesiology2549-22762018-01-0123909410.15562/bjoa.v2i3.100Dexmedetomidine provides better hemodynamic stability compared to clonidine in spine surgeryI Ketut SuyasaChristopher RyalinoNi Putu Novita PradnyaniIntroduction: Spine surgery presents a number of challenges to the anesthesiologist. The a2 adrenergic agonist drugs are commonly used in such cases to provide hemodynamic and sympathoadrenal stability. Dexmedetomidine (DEX) is one of the most potent and highly selective a2-adrenergic receptor agonists. Another a2 adrenergic agonist drug that is used widely is clonidine. The study aims to compare both drugs in terms of hemodynamic stability in spine surgeries. Patients and Methods: 30 patients underwent spinal surgery were classified into one of the following group: DEX group (received DEX 1 mcg/kg in 10 minutes followed by 0.5 mcg/kg/hour during the course of the surgery) or CLO group (received clonidine 1 mcg/kg in 10 minutes followed by 1 mcg/kg/hour during surgery), by consecutive sampling. All other treatments and medications were similar in both groups. The systolic and diastolic blood pressure, mean arterial pressure, and heart rate were recorded every 5 minutes. Data was then analyzed by SPSS. Result: The patients in the DEX group had a better mean arterial pressure (p=0.002) and heart rate (p=0.018) stability compared to those in the CLO group. Conclusion: The administration of dexmedetomidine provides a better hemodynamic stability compared to clonidine in patients underwent spinal surgery.http://www.bjoaonline.com/article.asp?issn=2549-2276;year=2018;volume=2;issue=3;spage=90;epage=94;aulast=Suyasa;type=0spine surgerydexmedetomidineclonidinehemodynamic stability. |
| spellingShingle | I Ketut Suyasa Christopher Ryalino Ni Putu Novita Pradnyani Dexmedetomidine provides better hemodynamic stability compared to clonidine in spine surgery Bali Journal of Anesthesiology spine surgery dexmedetomidine clonidine hemodynamic stability. |
| title | Dexmedetomidine provides better hemodynamic stability compared to clonidine in spine surgery |
| title_full | Dexmedetomidine provides better hemodynamic stability compared to clonidine in spine surgery |
| title_fullStr | Dexmedetomidine provides better hemodynamic stability compared to clonidine in spine surgery |
| title_full_unstemmed | Dexmedetomidine provides better hemodynamic stability compared to clonidine in spine surgery |
| title_short | Dexmedetomidine provides better hemodynamic stability compared to clonidine in spine surgery |
| title_sort | dexmedetomidine provides better hemodynamic stability compared to clonidine in spine surgery |
| topic | spine surgery dexmedetomidine clonidine hemodynamic stability. |
| url | http://www.bjoaonline.com/article.asp?issn=2549-2276;year=2018;volume=2;issue=3;spage=90;epage=94;aulast=Suyasa;type=0 |
| work_keys_str_mv | AT iketutsuyasa dexmedetomidineprovidesbetterhemodynamicstabilitycomparedtoclonidineinspinesurgery AT christopherryalino dexmedetomidineprovidesbetterhemodynamicstabilitycomparedtoclonidineinspinesurgery AT niputunovitapradnyani dexmedetomidineprovidesbetterhemodynamicstabilitycomparedtoclonidineinspinesurgery |