Synthesis Of 1-phenyl-4-(3’, 4’-dimethoxy phenyl)-1-Buten-3-on From Eugenol
The synthesis of 1-phenyl-4-(3’, 4’-dimethoxy phenyl)-1-buten-3-one from eugenol has been done through four reaction steps. The metilation of eugenol with dimethyl sulphate yields 81.81% of methyl eugenol. Oxymercuration-demercuration of methyl eugenol with mercury acetate yields 67.27% of met...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Department of Chemistry, Pattimura University
2014-07-01
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| Series: | Indonesian Journal of Chemical Research |
| Subjects: | |
| Online Access: | https://ojs3.unpatti.ac.id/index.php/ijcr/article/view/83 |
| Summary: | The synthesis of 1-phenyl-4-(3’, 4’-dimethoxy phenyl)-1-buten-3-one from eugenol has been done through four
reaction steps. The metilation of eugenol with dimethyl sulphate yields 81.81% of methyl eugenol.
Oxymercuration-demercuration of methyl eugenol with mercury acetate yields 67.27% of methyl eugenyl
alcohol. Oxidation of methyl eugenyl alcohol with pyridinium chloro chromate (PCC) yields 45.31% of methyl
eugenyl ketone. Aldol condensation reaction of methyl eugenyl ketone with benzaldehide catalyzed by potasium
hydroxyde yields 7.38% of 1-phenyl4-(3’,4’-dimethoxyphenyl)-1-buten-3-one. The purity of compounds was
tested by GC and LC. The Elucidation of structure was analyzed by FTIR, GC-MS, LC-ESI-MS, and
H-NMR. |
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| ISSN: | 2338-5359 2614-2627 |