Assessment of the role of afucosylated glycoforms on the in vitro antibody-dependent phagocytosis activity of an antibody to Aβ aggregates

Assessment of the role of afucosylated glycoforms on the in vitro antibody-dependent phagocytosis activity of an antibody to Aβ aggregates

The terminal sugars of Fc glycans can influence the Fc-dependent biological activities of monoclonal antibody therapeutics. Afucosylated N-glycans have been shown to significantly alter binding to FcγRIIIa and affect antibody-dependent cell-mediated cytotoxicity (ADCC). Therefore, in order to mainta...

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Bibliographic Details
Main Authors: Allyson Kwiatkowski, Carl Co, Sei Kameoka, An Zhang, John Coughlin, Tom Cameron, Eric Chiao, Svetlana Bergelson, Cullen Schmid Mason
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:mAbs
Subjects:
Antibody
IgG1
antibody-dependent cell-mediated phagocytosis
ADCP
phagocytosis
Fc effector function
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2020.1803645

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