Increased Serum Growth Differentiation Factor 15 Levels may be Associated with Diastolic Dysfunction in Acromegaly
Introduction:Growth differentiation factor-15 (GDF-15) is a cytokine that is associated with various metabolic and cardiac changes. Acromegaly is a chronic multisystemic disease that causes cardiac dysfunction due to an increased levels of growth hormone. We evaluated the association of GDF-15 with...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2022-08-01
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| Series: | İstanbul Medical Journal |
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http://istanbulmedicaljournal.org/archives/archive-detail/article-preview/ncreased-serum-growth-differentiation-factor-15-le/52710
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| _version_ | 1797922209850720256 |
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| author | Yalçın Hacıoğlu Mehmet Emin Pişkinpaşa Pelin Kılıçkaya Mutlu Niyazoğlu Burcu Hacıoğlu Esra Hatipoğlu |
| author_facet | Yalçın Hacıoğlu Mehmet Emin Pişkinpaşa Pelin Kılıçkaya Mutlu Niyazoğlu Burcu Hacıoğlu Esra Hatipoğlu |
| author_sort | Yalçın Hacıoğlu |
| collection | DOAJ |
| description | Introduction:Growth differentiation factor-15 (GDF-15) is a cytokine that is associated with various metabolic and cardiac changes. Acromegaly is a chronic multisystemic disease that causes cardiac dysfunction due to an increased levels of growth hormone. We evaluated the association of GDF-15 with diastolic dysfunction in acromegaly.Methods:Fifty-four patients with acromegaly [active (n=24), inactive (n=30)] and 34 healthy controls were included in the study. The acromegaly group (AG) and control group (CG) were compared for their blood pressures, metabolic parameters, GDF-15 levels, and echocardiographic findings. The correlation analysis was performed between the GDF-15 and the parameters that may be associated with it in the AG.Results:GDF-15 was significantly higher in AG than in the CG (p<0.001). GDF-15 was positively correlated with body mass index (r=0.4, p=0.008) and negatively correlated with fasting blood glucose (r=-0.4, p=0.004). GDF-15 was also positively correlated with diastolic blood pressure (DBP) (r=0.4, p=0.002). Among echocardiographic findings, end-diastolic volume (EDV), and stroke volume (SV) were negatively correlated with GDF-15 levels (r=-0.4, p=0.003, and r=-0.4, p=0.03, respectively).Conclusion:GDF-15 was detected to be significantly increased in patients with acromegaly. This increment was associated with subtle changes in DBP, EDV, and SV. Therefore, GDF-15 may play a role in diastolic impairment at the cardiac involvement in acromegaly. |
| first_indexed | 2024-04-10T14:27:53Z |
| format | Article |
| id | doaj.art-de7777459e1949278c0bb163c66aba13 |
| institution | Directory Open Access Journal |
| issn | 2619-9793 2148-094X |
| language | English |
| last_indexed | 2024-04-10T14:27:53Z |
| publishDate | 2022-08-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | İstanbul Medical Journal |
| spelling | doaj.art-de7777459e1949278c0bb163c66aba132023-02-15T16:09:00ZengGalenos Yayineviİstanbul Medical Journal2619-97932148-094X2022-08-0123317918210.4274/imj.galenos.2022.4478813049054Increased Serum Growth Differentiation Factor 15 Levels may be Associated with Diastolic Dysfunction in AcromegalyYalçın Hacıoğlu0Mehmet Emin Pişkinpaşa1Pelin Kılıçkaya2Mutlu Niyazoğlu3Burcu Hacıoğlu4Esra Hatipoğlu5 University of Health Sciences Turkey, İstanbul Training and Research Hospital, Clinic of Family Medicine, İstanbul, Turkey University of Health Sciences Turkey, İstanbul Training and Research Hospital, Clinic of Internal Medicine, İstanbul, Turkey Burdur Tefenni State Hospital, Clinic of Family Medicine, Burdur, Turkey University of Health Sciences Turkey, Başakşehir Çam and Sakura City Hospital, Clinic of Endocrinology and Metabolism, İstanbul, Turkey University of Health Sciences Turkey, Haseki Training and Research Hospital, Clinic of Internal Medicine, İstanbul, Turkey University of Health Sciences Turkey, Başakşehir Çam and Sakura City Hospital, Clinic of Endocrinology and Metabolism, İstanbul, Turkey Introduction:Growth differentiation factor-15 (GDF-15) is a cytokine that is associated with various metabolic and cardiac changes. Acromegaly is a chronic multisystemic disease that causes cardiac dysfunction due to an increased levels of growth hormone. We evaluated the association of GDF-15 with diastolic dysfunction in acromegaly.Methods:Fifty-four patients with acromegaly [active (n=24), inactive (n=30)] and 34 healthy controls were included in the study. The acromegaly group (AG) and control group (CG) were compared for their blood pressures, metabolic parameters, GDF-15 levels, and echocardiographic findings. The correlation analysis was performed between the GDF-15 and the parameters that may be associated with it in the AG.Results:GDF-15 was significantly higher in AG than in the CG (p<0.001). GDF-15 was positively correlated with body mass index (r=0.4, p=0.008) and negatively correlated with fasting blood glucose (r=-0.4, p=0.004). GDF-15 was also positively correlated with diastolic blood pressure (DBP) (r=0.4, p=0.002). Among echocardiographic findings, end-diastolic volume (EDV), and stroke volume (SV) were negatively correlated with GDF-15 levels (r=-0.4, p=0.003, and r=-0.4, p=0.03, respectively).Conclusion:GDF-15 was detected to be significantly increased in patients with acromegaly. This increment was associated with subtle changes in DBP, EDV, and SV. Therefore, GDF-15 may play a role in diastolic impairment at the cardiac involvement in acromegaly. http://istanbulmedicaljournal.org/archives/archive-detail/article-preview/ncreased-serum-growth-differentiation-factor-15-le/52710 acromegalycardiac complicationsdiastolic dysfunctiongrowth differentiation factor 15 |
| spellingShingle | Yalçın Hacıoğlu Mehmet Emin Pişkinpaşa Pelin Kılıçkaya Mutlu Niyazoğlu Burcu Hacıoğlu Esra Hatipoğlu Increased Serum Growth Differentiation Factor 15 Levels may be Associated with Diastolic Dysfunction in Acromegaly İstanbul Medical Journal acromegaly cardiac complications diastolic dysfunction growth differentiation factor 15 |
| title | Increased Serum Growth Differentiation Factor 15 Levels may be Associated with Diastolic Dysfunction in Acromegaly |
| title_full | Increased Serum Growth Differentiation Factor 15 Levels may be Associated with Diastolic Dysfunction in Acromegaly |
| title_fullStr | Increased Serum Growth Differentiation Factor 15 Levels may be Associated with Diastolic Dysfunction in Acromegaly |
| title_full_unstemmed | Increased Serum Growth Differentiation Factor 15 Levels may be Associated with Diastolic Dysfunction in Acromegaly |
| title_short | Increased Serum Growth Differentiation Factor 15 Levels may be Associated with Diastolic Dysfunction in Acromegaly |
| title_sort | increased serum growth differentiation factor 15 levels may be associated with diastolic dysfunction in acromegaly |
| topic | acromegaly cardiac complications diastolic dysfunction growth differentiation factor 15 |
| url |
http://istanbulmedicaljournal.org/archives/archive-detail/article-preview/ncreased-serum-growth-differentiation-factor-15-le/52710
|
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