Type-1 metabotropic glutamate receptor signaling in cerebellar Purkinje cells in health and disease [version 1; referees: 3 approved]
The cerebellum is a brain structure involved in coordination, control, and learning of movements, as well as certain aspects of cognitive function. Purkinje cells are the sole output neurons from the cerebellar cortex and therefore play crucial roles in the overall function of the cerebellum. The ty...
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2017-04-01
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| Series: | F1000Research |
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| Online Access: | https://f1000research.com/articles/6-416/v1 |
| _version_ | 1818282926922530816 |
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| author | Masanobu Kano Takaki Watanabe |
| author_facet | Masanobu Kano Takaki Watanabe |
| author_sort | Masanobu Kano |
| collection | DOAJ |
| description | The cerebellum is a brain structure involved in coordination, control, and learning of movements, as well as certain aspects of cognitive function. Purkinje cells are the sole output neurons from the cerebellar cortex and therefore play crucial roles in the overall function of the cerebellum. The type-1 metabotropic glutamate receptor (mGluR1) is a key “hub” molecule that is critically involved in the regulation of synaptic wiring, excitability, synaptic response, and synaptic plasticity of Purkinje cells. In this review, we aim to highlight how mGluR1 controls these events in Purkinje cells. We also describe emerging evidence that altered mGluR1 signaling in Purkinje cells underlies cerebellar dysfunctions in several clinically relevant mouse models of human ataxias. |
| first_indexed | 2024-12-13T00:28:47Z |
| format | Article |
| id | doaj.art-de77eba47a9e44aab4c7ead16b177fb3 |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-12-13T00:28:47Z |
| publishDate | 2017-04-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-de77eba47a9e44aab4c7ead16b177fb32022-12-22T00:05:22ZengF1000 Research LtdF1000Research2046-14022017-04-01610.12688/f1000research.10485.111298Type-1 metabotropic glutamate receptor signaling in cerebellar Purkinje cells in health and disease [version 1; referees: 3 approved]Masanobu Kano0Takaki Watanabe1Department of Neurophysiology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, JapanDepartment of Neurophysiology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, JapanThe cerebellum is a brain structure involved in coordination, control, and learning of movements, as well as certain aspects of cognitive function. Purkinje cells are the sole output neurons from the cerebellar cortex and therefore play crucial roles in the overall function of the cerebellum. The type-1 metabotropic glutamate receptor (mGluR1) is a key “hub” molecule that is critically involved in the regulation of synaptic wiring, excitability, synaptic response, and synaptic plasticity of Purkinje cells. In this review, we aim to highlight how mGluR1 controls these events in Purkinje cells. We also describe emerging evidence that altered mGluR1 signaling in Purkinje cells underlies cerebellar dysfunctions in several clinically relevant mouse models of human ataxias.https://f1000research.com/articles/6-416/v1Animal GeneticsBehavioral NeuroscienceMedical GeneticsMotor SystemsMovement DisordersNeurobiology of Disease & RegenerationNeurodevelopmentNeurogeneticsNeuronal Signaling MechanismsNeuropharmacology & Psychopharmacology |
| spellingShingle | Masanobu Kano Takaki Watanabe Type-1 metabotropic glutamate receptor signaling in cerebellar Purkinje cells in health and disease [version 1; referees: 3 approved] F1000Research Animal Genetics Behavioral Neuroscience Medical Genetics Motor Systems Movement Disorders Neurobiology of Disease & Regeneration Neurodevelopment Neurogenetics Neuronal Signaling Mechanisms Neuropharmacology & Psychopharmacology |
| title | Type-1 metabotropic glutamate receptor signaling in cerebellar Purkinje cells in health and disease [version 1; referees: 3 approved] |
| title_full | Type-1 metabotropic glutamate receptor signaling in cerebellar Purkinje cells in health and disease [version 1; referees: 3 approved] |
| title_fullStr | Type-1 metabotropic glutamate receptor signaling in cerebellar Purkinje cells in health and disease [version 1; referees: 3 approved] |
| title_full_unstemmed | Type-1 metabotropic glutamate receptor signaling in cerebellar Purkinje cells in health and disease [version 1; referees: 3 approved] |
| title_short | Type-1 metabotropic glutamate receptor signaling in cerebellar Purkinje cells in health and disease [version 1; referees: 3 approved] |
| title_sort | type 1 metabotropic glutamate receptor signaling in cerebellar purkinje cells in health and disease version 1 referees 3 approved |
| topic | Animal Genetics Behavioral Neuroscience Medical Genetics Motor Systems Movement Disorders Neurobiology of Disease & Regeneration Neurodevelopment Neurogenetics Neuronal Signaling Mechanisms Neuropharmacology & Psychopharmacology |
| url | https://f1000research.com/articles/6-416/v1 |
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