Behavioral and Cortical Effects during Attention Driven Brain-Computer Interface Operations in Spatial Neglect: A Feasibility Case Study
During the last years, several studies have suggested that Brain-Computer Interface (BCI) can play a critical role in the field of motor rehabilitation. In this case report, we aim to investigate the feasibility of a covert visuospatial attention (CVSA) driven BCI in three patients with left spatial...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-06-01
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| Series: | Frontiers in Human Neuroscience |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fnhum.2017.00336/full |
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| author | Luca Tonin Marco Pitteri Robert Leeb Huaijian Zhang Emanuele Menegatti Francesco Piccione Francesco Piccione José del R. Millán |
| author_facet | Luca Tonin Marco Pitteri Robert Leeb Huaijian Zhang Emanuele Menegatti Francesco Piccione Francesco Piccione José del R. Millán |
| author_sort | Luca Tonin |
| collection | DOAJ |
| description | During the last years, several studies have suggested that Brain-Computer Interface (BCI) can play a critical role in the field of motor rehabilitation. In this case report, we aim to investigate the feasibility of a covert visuospatial attention (CVSA) driven BCI in three patients with left spatial neglect (SN). We hypothesize that such a BCI is able to detect attention task-specific brain patterns in SN patients and can induce significant changes in their abnormal cortical activity (α-power modulation, feature recruitment, and connectivity). The three patients were asked to control online a CVSA BCI by focusing their attention at different spatial locations, including their neglected (left) space. As primary outcome, results show a significant improvement of the reaction time in the neglected space between calibration and online modalities (p < 0.01) for the two out of three patients that had the slowest initial behavioral response. Such an evolution of reaction time negatively correlates (p < 0.05) with an increment of the Individual α-Power computed in the pre-cue interval. Furthermore, all patients exhibited a significant reduction of the inter-hemispheric imbalance (p < 0.05) over time in the parieto-occipital regions. Finally, analysis on the inter-hemispheric functional connectivity suggests an increment across modalities for regions in the affected (right) hemisphere and decrement for those in the healthy. Although preliminary, this feasibility study suggests a possible role of BCI in the therapeutic treatment of lateralized, attention-based visuospatial deficits. |
| first_indexed | 2024-12-10T07:03:02Z |
| format | Article |
| id | doaj.art-de788f4213f546df856e61752393b34c |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-12-10T07:03:02Z |
| publishDate | 2017-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-de788f4213f546df856e61752393b34c2022-12-22T01:58:16ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612017-06-011110.3389/fnhum.2017.00336278014Behavioral and Cortical Effects during Attention Driven Brain-Computer Interface Operations in Spatial Neglect: A Feasibility Case StudyLuca Tonin0Marco Pitteri1Robert Leeb2Huaijian Zhang3Emanuele Menegatti4Francesco Piccione5Francesco Piccione6José del R. Millán7Chair in Brain-Machine Interface, Center for Neuroprosthetics, École Polytechnique Fédérale de LausanneGeneva, SwitzerlandNeurology Section, Department of Neurosciences, Biomedicine and Movement Sciences, University of VeronaVerona, ItalyChair in Brain-Machine Interface, Center for Neuroprosthetics, École Polytechnique Fédérale de LausanneGeneva, SwitzerlandChair in Brain-Machine Interface, Center for Neuroprosthetics, École Polytechnique Fédérale de LausanneGeneva, SwitzerlandIntelligent Autonomous Systems Laboratory, Department of Information Engineering, University of PadovaPadova, ItalyLaboratory of Neuropsychology, IRCCS San Camillo Hospital FoundationVenice, ItalyLaboratory of Neurophysiology, IRCCS San Camillo Hospital FoundationVenice, ItalyChair in Brain-Machine Interface, Center for Neuroprosthetics, École Polytechnique Fédérale de LausanneGeneva, SwitzerlandDuring the last years, several studies have suggested that Brain-Computer Interface (BCI) can play a critical role in the field of motor rehabilitation. In this case report, we aim to investigate the feasibility of a covert visuospatial attention (CVSA) driven BCI in three patients with left spatial neglect (SN). We hypothesize that such a BCI is able to detect attention task-specific brain patterns in SN patients and can induce significant changes in their abnormal cortical activity (α-power modulation, feature recruitment, and connectivity). The three patients were asked to control online a CVSA BCI by focusing their attention at different spatial locations, including their neglected (left) space. As primary outcome, results show a significant improvement of the reaction time in the neglected space between calibration and online modalities (p < 0.01) for the two out of three patients that had the slowest initial behavioral response. Such an evolution of reaction time negatively correlates (p < 0.05) with an increment of the Individual α-Power computed in the pre-cue interval. Furthermore, all patients exhibited a significant reduction of the inter-hemispheric imbalance (p < 0.05) over time in the parieto-occipital regions. Finally, analysis on the inter-hemispheric functional connectivity suggests an increment across modalities for regions in the affected (right) hemisphere and decrement for those in the healthy. Although preliminary, this feasibility study suggests a possible role of BCI in the therapeutic treatment of lateralized, attention-based visuospatial deficits.http://journal.frontiersin.org/article/10.3389/fnhum.2017.00336/fullbrain-computer interfacespatial neglectcovert visuospatial attentionelectroencephalogramalpha oscillationsfunctional connectivity |
| spellingShingle | Luca Tonin Marco Pitteri Robert Leeb Huaijian Zhang Emanuele Menegatti Francesco Piccione Francesco Piccione José del R. Millán Behavioral and Cortical Effects during Attention Driven Brain-Computer Interface Operations in Spatial Neglect: A Feasibility Case Study Frontiers in Human Neuroscience brain-computer interface spatial neglect covert visuospatial attention electroencephalogram alpha oscillations functional connectivity |
| title | Behavioral and Cortical Effects during Attention Driven Brain-Computer Interface Operations in Spatial Neglect: A Feasibility Case Study |
| title_full | Behavioral and Cortical Effects during Attention Driven Brain-Computer Interface Operations in Spatial Neglect: A Feasibility Case Study |
| title_fullStr | Behavioral and Cortical Effects during Attention Driven Brain-Computer Interface Operations in Spatial Neglect: A Feasibility Case Study |
| title_full_unstemmed | Behavioral and Cortical Effects during Attention Driven Brain-Computer Interface Operations in Spatial Neglect: A Feasibility Case Study |
| title_short | Behavioral and Cortical Effects during Attention Driven Brain-Computer Interface Operations in Spatial Neglect: A Feasibility Case Study |
| title_sort | behavioral and cortical effects during attention driven brain computer interface operations in spatial neglect a feasibility case study |
| topic | brain-computer interface spatial neglect covert visuospatial attention electroencephalogram alpha oscillations functional connectivity |
| url | http://journal.frontiersin.org/article/10.3389/fnhum.2017.00336/full |
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