A case report on Mycobacterium houstonense infection after total hip arthroplasty
Abstract Background Mycobacterium houstonense is a category of rapidly growing mycobacteria that is gram-positive, acid-fast, polycrystalline, and non-spore-forming. There have been few reports of human infection caused by Mycobacterium houstonense worldwide. Case presentation We present a case of c...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-10-01
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| Series: | BMC Infectious Diseases |
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| Online Access: | https://doi.org/10.1186/s12879-023-08705-y |
| _version_ | 1797453774624653312 |
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| author | ZhiPeng Li ZhaoFeng Yuan HuiLing Cao DaWei Huan Yue Qiu TianWei Xia JiRong Shen |
| author_facet | ZhiPeng Li ZhaoFeng Yuan HuiLing Cao DaWei Huan Yue Qiu TianWei Xia JiRong Shen |
| author_sort | ZhiPeng Li |
| collection | DOAJ |
| description | Abstract Background Mycobacterium houstonense is a category of rapidly growing mycobacteria that is gram-positive, acid-fast, polycrystalline, and non-spore-forming. There have been few reports of human infection caused by Mycobacterium houstonense worldwide. Case presentation We present a case of chronic periprosthetic joint infection caused by Mycobacterium houstonense in an elderly female patient. The patient developed signs of infection after undergoing total hip arthroplasty. Despite receiving antibiotic treatment and revision surgery, the signs of infection recurred repeatedly. Multiple bacterial cultures during the treatment period were negative. Later, we identified the pathogenic bacteria Mycobacterium houstonense through mNGS testing, isolated the bacteria from the ultrasonically centrifuged fluid of the prosthesis and obtained drug sensitivity results. Finally, we performed a revision surgery and treated the patient with moxifloxacin and clindamycin. After treatment, the patient did not show signs of infection recurrence during 24 months of follow-up. Conclusion Through a relevant literature search, we believe that Mycobacterium houstonense may show higher sensitivity to amikacin and quinolone antibiotics. Additionally, clarifying occult infection sources through methods such as gene testing will improve the diagnosis and treatment of periprosthetic joint infection. |
| first_indexed | 2024-03-09T15:27:44Z |
| format | Article |
| id | doaj.art-de7b7eaef0a4458592a13af4514503e1 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-03-09T15:27:44Z |
| publishDate | 2023-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-de7b7eaef0a4458592a13af4514503e12023-11-26T12:27:19ZengBMCBMC Infectious Diseases1471-23342023-10-012311610.1186/s12879-023-08705-yA case report on Mycobacterium houstonense infection after total hip arthroplastyZhiPeng Li0ZhaoFeng Yuan1HuiLing Cao2DaWei Huan3Yue Qiu4TianWei Xia5JiRong Shen6Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Provincial Hospital of Chinese MedicineAffiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Provincial Hospital of Chinese MedicineAffiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Provincial Hospital of Chinese MedicineAffiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Provincial Hospital of Chinese MedicineAffiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Provincial Hospital of Chinese MedicineAffiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Provincial Hospital of Chinese MedicineAffiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Provincial Hospital of Chinese MedicineAbstract Background Mycobacterium houstonense is a category of rapidly growing mycobacteria that is gram-positive, acid-fast, polycrystalline, and non-spore-forming. There have been few reports of human infection caused by Mycobacterium houstonense worldwide. Case presentation We present a case of chronic periprosthetic joint infection caused by Mycobacterium houstonense in an elderly female patient. The patient developed signs of infection after undergoing total hip arthroplasty. Despite receiving antibiotic treatment and revision surgery, the signs of infection recurred repeatedly. Multiple bacterial cultures during the treatment period were negative. Later, we identified the pathogenic bacteria Mycobacterium houstonense through mNGS testing, isolated the bacteria from the ultrasonically centrifuged fluid of the prosthesis and obtained drug sensitivity results. Finally, we performed a revision surgery and treated the patient with moxifloxacin and clindamycin. After treatment, the patient did not show signs of infection recurrence during 24 months of follow-up. Conclusion Through a relevant literature search, we believe that Mycobacterium houstonense may show higher sensitivity to amikacin and quinolone antibiotics. Additionally, clarifying occult infection sources through methods such as gene testing will improve the diagnosis and treatment of periprosthetic joint infection.https://doi.org/10.1186/s12879-023-08705-yRapidly growing mycobacteriaMycobacteria houstonenseMetagenomic next-generation sequencingPeriprosthetic joint InfectionTwo-stage revision Surgery |
| spellingShingle | ZhiPeng Li ZhaoFeng Yuan HuiLing Cao DaWei Huan Yue Qiu TianWei Xia JiRong Shen A case report on Mycobacterium houstonense infection after total hip arthroplasty BMC Infectious Diseases Rapidly growing mycobacteria Mycobacteria houstonense Metagenomic next-generation sequencing Periprosthetic joint Infection Two-stage revision Surgery |
| title | A case report on Mycobacterium houstonense infection after total hip arthroplasty |
| title_full | A case report on Mycobacterium houstonense infection after total hip arthroplasty |
| title_fullStr | A case report on Mycobacterium houstonense infection after total hip arthroplasty |
| title_full_unstemmed | A case report on Mycobacterium houstonense infection after total hip arthroplasty |
| title_short | A case report on Mycobacterium houstonense infection after total hip arthroplasty |
| title_sort | case report on mycobacterium houstonense infection after total hip arthroplasty |
| topic | Rapidly growing mycobacteria Mycobacteria houstonense Metagenomic next-generation sequencing Periprosthetic joint Infection Two-stage revision Surgery |
| url | https://doi.org/10.1186/s12879-023-08705-y |
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