An evaluation of the genome-wide false positive rates of common methods for identifying differentially methylated regions using illumina methylation arrays

An evaluation of the genome-wide false positive rates of common methods for identifying differentially methylated regions using illumina methylation arrays

Differentially methylated regions (DMRs) are genomic regions with specific methylation patterns across multiple loci that are associated with a phenotype. We examined the genome-wide false positive (GFP) rates of five widely used DMR methods: comb-p, Bumphunter, DMRcate, mCSEA and coMethDMR using bo...

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Bibliographic Details
Main Authors: Yuanchao Zheng, Kathryn L. Lunetta, Chunyu Liu, Seyma Katrinli, Alicia K. Smith, Mark W. Miller, Mark W. Logue
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Epigenetics
Subjects:
dna methylation
differentially methylated region
genome-wide false positive rate
Online Access:http://dx.doi.org/10.1080/15592294.2022.2115600

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