Nrf2 mitigates prolonged PM2.5 exposure-triggered liver inflammation by positively regulating SIKE activity: Protection by Juglanin

Nrf2 mitigates prolonged PM2.5 exposure-triggered liver inflammation by positively regulating SIKE activity: Protection by Juglanin

Air pollution containing particulate matter (PM) less than 2.5 μm (PM2.5) plays an essential role in regulating hepatic disease. However, its molecular mechanism is not yet clear, lacking effective therapeutic strategies. In this study, we attempted to investigate the effects and mechanisms of PM2.5...

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Bibliographic Details
Main Authors: Chenxu Ge, Jun Tan, Shaoyu Zhong, Lili Lai, Geng Chen, Junjie Zhao, Chao Yi, Longyan Wang, Liwei Zhou, Tingting Tang, Qiufeng Yang, Deshuai Lou, Qiang Li, Yekuan Wu, Linfeng Hu, Gang Kuang, Xi Liu, Bochu Wang, Minxuan Xu
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Redox Biology
Subjects:
PM2.5
Nrf2/SIKE
TBK1/NF-κB
Inflammation and oxidative stress
Juglanin
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231720308508

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