FNDC5/irisin ameliorates bone loss of type 1 diabetes by suppressing endoplasmic reticulum stress‑mediated ferroptosis

FNDC5/irisin ameliorates bone loss of type 1 diabetes by suppressing endoplasmic reticulum stress‑mediated ferroptosis

Abstract Background Ferroptosis is known to play a crucial role in diabetic osteopathy. However, key genes and molecular mechanisms remain largely unclear. This study aimed to identify a crucial ferroptosis-related differentially expressed gene (FR-DEG) in diabetic osteopathy and investigate its pot...

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Bibliographic Details
Main Authors: Qianqian Dong, Ziqi Han, Mingdong Gao, Limin Tian
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Ferroptosis
ER stress
FNDC5/irisin
Type 1 diabetes mellitus
Diabetic osteopathy
Bioinformatics
Online Access:https://doi.org/10.1186/s13018-024-04701-3

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