Genetic variation of the mitochondrial D-loop region containing mitochondrial transcription factor A (TFAM) binding sites is not associated with marbling in Wagyu × Limousin F2 crosses
Mitochondrial transcription factor A (TFAM) is a nucleus-encoded protein that is essential for initiation of transcription and replication of mitochondrial DNA (mtDNA). It has been shown that TFAM binds the entire length of the mtDNA, but with higher affinity to sequences around both mitochondrial...
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| Format: | Article |
| Language: | English |
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University of Ljubljana Press (Založba Univerze v Ljubljani)
2005-12-01
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| Series: | Acta Agriculturae Slovenica |
| Subjects: | |
| Online Access: | https://journals.uni-lj.si/aas/article/view/15164 |
| _version_ | 1797390777722077184 |
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| author | Tanja KUNEJ Jennifer J. MICHAL Peter DOVČ Zhihua JIANG |
| author_facet | Tanja KUNEJ Jennifer J. MICHAL Peter DOVČ Zhihua JIANG |
| author_sort | Tanja KUNEJ |
| collection | DOAJ |
| description |
Mitochondrial transcription factor A (TFAM) is a nucleus-encoded protein that is essential for initiation of transcription and replication of mitochondrial DNA (mtDNA). It has been shown that TFAM binds the entire length of the mtDNA, but with higher affinity to sequences around both mitochondrial promoters located in 3’ domain of the D-loop region. The objectives of this study were to detect genetic polymorphisms in the sequence flanking TFAM binding sites of the mtDNA D-loop region and investigate their associations with marbling in Wagyu x Limousin F2 crosses. We identified six polymorphis sites in the TFAM binding sites of the D-loop mtDNA (G8A, T106C, A169G, A173G and C190T and one insertion/deletion at position 221 with one or two cytosines) with no significant differences in frequencies of polymorphic sites between extreme high/low marbling pools.
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| first_indexed | 2024-03-08T23:23:13Z |
| format | Article |
| id | doaj.art-de81b6701f814c0282c125e055099c85 |
| institution | Directory Open Access Journal |
| issn | 1854-1941 |
| language | English |
| last_indexed | 2024-03-08T23:23:13Z |
| publishDate | 2005-12-01 |
| publisher | University of Ljubljana Press (Založba Univerze v Ljubljani) |
| record_format | Article |
| series | Acta Agriculturae Slovenica |
| spelling | doaj.art-de81b6701f814c0282c125e055099c852023-12-14T22:15:39ZengUniversity of Ljubljana Press (Založba Univerze v Ljubljani)Acta Agriculturae Slovenica1854-19412005-12-01862Genetic variation of the mitochondrial D-loop region containing mitochondrial transcription factor A (TFAM) binding sites is not associated with marbling in Wagyu × Limousin F2 crossesTanja KUNEJ0Jennifer J. MICHAL1Peter DOVČ2Zhihua JIANG3Univ. of Ljubljana, Biotechnical Fac., Zootechnical Dept., Groblje 3, SI-1230 DomžaleWashington State Univ., Dept. of Animal Sciences, Pullman, WA 99164-6351Univ. of Ljubljana, Biotechnical Fac., Zootechnical Dept., Groblje 3, SI-1230 DomžaleWashington State Univ., Dept. of Animal Sciences, Pullman, WA 99164-6351 Mitochondrial transcription factor A (TFAM) is a nucleus-encoded protein that is essential for initiation of transcription and replication of mitochondrial DNA (mtDNA). It has been shown that TFAM binds the entire length of the mtDNA, but with higher affinity to sequences around both mitochondrial promoters located in 3’ domain of the D-loop region. The objectives of this study were to detect genetic polymorphisms in the sequence flanking TFAM binding sites of the mtDNA D-loop region and investigate their associations with marbling in Wagyu x Limousin F2 crosses. We identified six polymorphis sites in the TFAM binding sites of the D-loop mtDNA (G8A, T106C, A169G, A173G and C190T and one insertion/deletion at position 221 with one or two cytosines) with no significant differences in frequencies of polymorphic sites between extreme high/low marbling pools. https://journals.uni-lj.si/aas/article/view/15164cattlebreedsLimousinWagyucrossesmolecular genetics |
| spellingShingle | Tanja KUNEJ Jennifer J. MICHAL Peter DOVČ Zhihua JIANG Genetic variation of the mitochondrial D-loop region containing mitochondrial transcription factor A (TFAM) binding sites is not associated with marbling in Wagyu × Limousin F2 crosses Acta Agriculturae Slovenica cattle breeds Limousin Wagyu crosses molecular genetics |
| title | Genetic variation of the mitochondrial D-loop region containing mitochondrial transcription factor A (TFAM) binding sites is not associated with marbling in Wagyu × Limousin F2 crosses |
| title_full | Genetic variation of the mitochondrial D-loop region containing mitochondrial transcription factor A (TFAM) binding sites is not associated with marbling in Wagyu × Limousin F2 crosses |
| title_fullStr | Genetic variation of the mitochondrial D-loop region containing mitochondrial transcription factor A (TFAM) binding sites is not associated with marbling in Wagyu × Limousin F2 crosses |
| title_full_unstemmed | Genetic variation of the mitochondrial D-loop region containing mitochondrial transcription factor A (TFAM) binding sites is not associated with marbling in Wagyu × Limousin F2 crosses |
| title_short | Genetic variation of the mitochondrial D-loop region containing mitochondrial transcription factor A (TFAM) binding sites is not associated with marbling in Wagyu × Limousin F2 crosses |
| title_sort | genetic variation of the mitochondrial d loop region containing mitochondrial transcription factor a tfam binding sites is not associated with marbling in wagyu limousin f2 crosses |
| topic | cattle breeds Limousin Wagyu crosses molecular genetics |
| url | https://journals.uni-lj.si/aas/article/view/15164 |
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