The Interplay of Permeability, Metabolism, Transporters, and Dosing in Determining the Dynamics of the Tissue/Plasma Partition Coefficient and Volume of Distribution—A Theoretical Investigation Using Permeability-Limited, Physiologically Based Pharmacokinetic Modeling

The Interplay of Permeability, Metabolism, Transporters, and Dosing in Determining the Dynamics of the Tissue/Plasma Partition Coefficient and Volume of Distribution—A Theoretical Investigation Using Permeability-Limited, Physiologically Based Pharmacokinetic Modeling

A permeability-limited physiologically based pharmacokinetic (PBPK) model featuring four subcompartments (corresponding to the intracellular and extracellular water of the tissue, the residual plasma, and blood cells) for each tissue has been developed in MATLAB/SimBiology and applied to various wha...

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Bibliographic Details
Main Authors:	Lu Gaohua, Mian Zhang, Caroline Sychterz, Ming Chang, Brian James Schmidt
Format:	Article
Language:	English
Published:	MDPI AG 2023-11-01
Series:	International Journal of Molecular Sciences
Subjects:	physiologically based pharmacokinetic (PBPK) model tissue/plasma partition coefficient (Kp) volume of distribution (Vd) permeability metabolism transporter
Online Access:	https://www.mdpi.com/1422-0067/24/22/16224

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