A four-protein metabolon assembled by a small peptide protein creates the pentacyclic carbonate ring of aldgamycins

A four-protein metabolon assembled by a small peptide protein creates the pentacyclic carbonate ring of aldgamycins

Organic carbonates (OCs) are a class of compounds featured by a carbonyl flanked by two alkoxy/aryloxy groups. They exist in either linear or cyclic forms, of which the majority encountered in nature adopt a pentacyclic structure. However, the enzymatic basis for pentacyclic carbonate ring formation...

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Bibliographic Details
Main Authors: Qiaozhen Wang, Xiaolong Tang, Ping Dai, Chuanxi Wang, Weiyang Zhang, Guodong Chen, Kui Hong, Dan Hu, Hao Gao, Xinsheng Yao
Format: Article
Language:English
Published: Elsevier 2021-02-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Aldgamycins
Biosynthesis
N-hydroxylcarbamoyl
Organic carbonate
Protein complex
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383520306572

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http://www.sciencedirect.com/science/article/pii/S2211383520306572

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