The role of ion channels in T cell function and disease
T lymphocytes (T cells) are an important sub-group of cells in our immune system responsible for cell-mediated adaptive responses and maintaining immune homeostasis. Abnormalities in T cell function, lead the way to the persistence of infection, impaired immunosurveillance, lack of suppression of ca...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-08-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1238171/full |
| _version_ | 1797733163128061952 |
|---|---|
| author | Nicholas Manolios Nicholas Manolios John Papaemmanouil David J. Adams |
| author_facet | Nicholas Manolios Nicholas Manolios John Papaemmanouil David J. Adams |
| author_sort | Nicholas Manolios |
| collection | DOAJ |
| description | T lymphocytes (T cells) are an important sub-group of cells in our immune system responsible for cell-mediated adaptive responses and maintaining immune homeostasis. Abnormalities in T cell function, lead the way to the persistence of infection, impaired immunosurveillance, lack of suppression of cancer growth, and autoimmune diseases. Ion channels play a critical role in the regulation of T cell signaling and cellular function and are often overlooked and understudied. Little is known about the ion “channelome” and the interaction of ion channels in immune cells. This review aims to summarize the published data on the impact of ion channels on T cell function and disease. The importance of ion channels in health and disease plus the fact they are easily accessible by virtue of being expressed on the surface of plasma membranes makes them excellent drug targets. |
| first_indexed | 2024-03-12T12:24:10Z |
| format | Article |
| id | doaj.art-de8722ed837c4be0b5aeacb5f13d2fec |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-12T12:24:10Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-de8722ed837c4be0b5aeacb5f13d2fec2023-08-30T05:00:39ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-08-011410.3389/fimmu.2023.12381711238171The role of ion channels in T cell function and diseaseNicholas Manolios0Nicholas Manolios1John Papaemmanouil2David J. Adams3Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, AustraliaDepartment of Rheumatology, Westmead Hospital, Sydney, NSW, AustraliaFaculty of Medicine and Health, The University of Sydney, Sydney, NSW, AustraliaIllawarra Health and Medical Research Institute (IHMRI), Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, NSW, AustraliaT lymphocytes (T cells) are an important sub-group of cells in our immune system responsible for cell-mediated adaptive responses and maintaining immune homeostasis. Abnormalities in T cell function, lead the way to the persistence of infection, impaired immunosurveillance, lack of suppression of cancer growth, and autoimmune diseases. Ion channels play a critical role in the regulation of T cell signaling and cellular function and are often overlooked and understudied. Little is known about the ion “channelome” and the interaction of ion channels in immune cells. This review aims to summarize the published data on the impact of ion channels on T cell function and disease. The importance of ion channels in health and disease plus the fact they are easily accessible by virtue of being expressed on the surface of plasma membranes makes them excellent drug targets.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1238171/fullion channelscalcium signallingT cellsantigen receptorsignal transductiontherapeutics |
| spellingShingle | Nicholas Manolios Nicholas Manolios John Papaemmanouil David J. Adams The role of ion channels in T cell function and disease Frontiers in Immunology ion channels calcium signalling T cells antigen receptor signal transduction therapeutics |
| title | The role of ion channels in T cell function and disease |
| title_full | The role of ion channels in T cell function and disease |
| title_fullStr | The role of ion channels in T cell function and disease |
| title_full_unstemmed | The role of ion channels in T cell function and disease |
| title_short | The role of ion channels in T cell function and disease |
| title_sort | role of ion channels in t cell function and disease |
| topic | ion channels calcium signalling T cells antigen receptor signal transduction therapeutics |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1238171/full |
| work_keys_str_mv | AT nicholasmanolios theroleofionchannelsintcellfunctionanddisease AT nicholasmanolios theroleofionchannelsintcellfunctionanddisease AT johnpapaemmanouil theroleofionchannelsintcellfunctionanddisease AT davidjadams theroleofionchannelsintcellfunctionanddisease AT nicholasmanolios roleofionchannelsintcellfunctionanddisease AT nicholasmanolios roleofionchannelsintcellfunctionanddisease AT johnpapaemmanouil roleofionchannelsintcellfunctionanddisease AT davidjadams roleofionchannelsintcellfunctionanddisease |