Gestational and Lactational Co-Exposure to DEHP and BPA Impairs Hepatic Function via PI3K/AKT/FOXO1 Pathway in Offspring

Gestational and Lactational Co-Exposure to DEHP and BPA Impairs Hepatic Function via PI3K/AKT/FOXO1 Pathway in Offspring

Di-(2-Ethylhexyl) phthalate (DEHP) and bisphenol A (BPA) present significant environmental endocrine-disrupting chemical properties. Although studies have implied reproductive impairment from exposure to BPA and DEHP, no study to date has shown the effect and mechanism of hepatic function after gest...

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Bibliographic Details
Main Authors: Minghan Wang, Yu Wang, Junyuan Han, Zhiwen Duan, Jiye Yin, Rigao Ding, Quanjun Wang
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Toxics
Subjects:
di-(2-ethylhexyl) phthalate
bisphenol A
mixture toxicity
metabolomics
PI3K/AKT/FOXO1 signaling pathway
molecular docking
Online Access:https://www.mdpi.com/2305-6304/11/3/216

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