Two distinct binding modes provide the RNA-binding protein RbFox with extraordinary sequence specificity

Here the authors show that the RRM of RbFox accomplishes extraordinary sequence specificity by employing functionally and structurally distinct binding modes - one for its cognate RNA and one for all non-cognate RNAs.

Bibliographic Details
Main Authors: Xuan Ye, Wen Yang, Soon Yi, Yanan Zhao, Gabriele Varani, Eckhard Jankowsky, Fan Yang
Format: Article
Language:English
Published: Nature Portfolio 2023-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-36394-3

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