Two distinct binding modes provide the RNA-binding protein RbFox with extraordinary sequence specificity
Here the authors show that the RRM of RbFox accomplishes extraordinary sequence specificity by employing functionally and structurally distinct binding modes - one for its cognate RNA and one for all non-cognate RNAs.
Main Authors: | Xuan Ye, Wen Yang, Soon Yi, Yanan Zhao, Gabriele Varani, Eckhard Jankowsky, Fan Yang |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2023-02-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-023-36394-3 |
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