| Summary: | Echinococcosis is a serious public health issue that affects people and livestock all over the world. Many synthetic and natural products have been examined in vitro and in vivo on <i>Echinococcus</i> species but only a few are used clinically, however, they may cause some complications and side effects. To overcome these limitations, new horizons of herbal drugs to cure echinococcosis are opening with every passing day. To summarize the developments during the last 21 years, we conducted this review of the literature to identify medicinal herbs utilized throughout the world that have anti-<i>Echinococcus</i> activity. From 2000 to 2021, data were carefully obtained from four English databases: Science Direct, PubMed, Scopus, and OpenGrey. Botanical name, extraction technique, extract quantities, efficacy, duration of treatment, year of publication, and half-maximal inhibitory concentration (IC<sub>50</sub>) values were all well noted. Ninety-one published papers, with 78 in vitro and 15 in vivo, fulfilled our selection criteria. Fifty-eight different plant species were thoroughly tested against <i>Echinococcus</i> <i>granulosus</i>. <i>Zataria multiflora</i>, <i>Nigella sativa</i>, <i>Berberis vulgaris</i>, <i>Zingiber officinale</i> (ginger), and <i>Allium sativum</i> were the most often utilized anti-<i>Echinococcus</i> herbs and the leaves of the herbs were extensively used. The pooled value of IC<sub>50</sub> was 61 (95% CI 60–61.9) according to the random effect model and a large degree of diversity among studies was observed. The current systematic study described the medicinal plants with anti-<i>Echinococcus</i> activity, which could be investigated in future experimental and clinical studies to identify their in vivo efficacy, lethal effects, and mechanisms of action.
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