Results of different kinds of carotid endarterectomy in patients with and without type 2 diabetes mellitus
BACKGROUND: Type 2 diabetes mellitus (DM) is one of the important markers for the development of adverse cardiovascular events after carotid endarterectomy (CEE). However, studies on this issue are based on small sample of patients and do not take into account the type of surgery as an additional fa...
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| Language: | English |
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Endocrinology Research Centre
2022-02-01
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| Series: | Сахарный диабет |
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| Online Access: | https://www.dia-endojournals.ru/jour/article/view/12722 |
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| author | А. N. Kazantsev R. A. Vinogradov M. A. Chernyavsky V. N. Kravchuk D. V. Shmatov A. A. Sorokin A. A. Erofeev V. A. Lutsenko R. V. Sultanov A. R. Shabaev I. M. Radjabov G. Sh. Bagdavadze N. E. Zarkua V. V. Matusevich E. F. Vaiman A. I. Solobuev S. V. Artyukhov R. Yu. Lider V. A. Porkhanov G. G. Khubulava |
| author_facet | А. N. Kazantsev R. A. Vinogradov M. A. Chernyavsky V. N. Kravchuk D. V. Shmatov A. A. Sorokin A. A. Erofeev V. A. Lutsenko R. V. Sultanov A. R. Shabaev I. M. Radjabov G. Sh. Bagdavadze N. E. Zarkua V. V. Matusevich E. F. Vaiman A. I. Solobuev S. V. Artyukhov R. Yu. Lider V. A. Porkhanov G. G. Khubulava |
| author_sort | А. N. Kazantsev |
| collection | DOAJ |
| description | BACKGROUND: Type 2 diabetes mellitus (DM) is one of the important markers for the development of adverse cardiovascular events after carotid endarterectomy (CEE). However, studies on this issue are based on small sample of patients and do not take into account the type of surgery as an additional factor of potentially negative impact on the course of the postoperative period.AIM: Analysis of hospital and long-term results of eversion and classical CEE with plastic surgery of the reconstruction zone with a biological patch in patients with type 2 diabetes and without it.MATERIALS AND METHODS: In this multicenter retrospective study from January 2010 to December 2020. included 5731 patients. Depending on the presence / absence of type 2 diabetes and the type of implemented CEE, 4 groups were formed: group 1 — 12.2% (n = 702) — patients with type 2 diabetes and eversion CEE; Group 2 — 55.0% (n = 3153) patients without type 2 diabetes and eversion CEE; Group 3 — 8.5% (n = 484) patients with type 2 diabetes and classical CEE; Group 4 — 24.3% (n = 1392) patients without type 2 diabetes and classical CEE. The duration of postoperative follow-up was 78.6 ± 39.2 months.RESULTS: At the long-term follow-up stage, patients with type 2 diabetes after the classical surgical technique demonstrated the highest rates of all types of complications: death (p <0.0001), MI (p = 0.011), ischemic stroke (p <0.0001), restenosis / occlusion of the ICA (p <0.0001), combined end point (p <0.0001). At the same time, the group of eversion CEE with impaired carbohydrate metabolism took the second position in terms of the prevalence of adverse events. These circumstances demonstrate that patch implantation is accompanied by an increased risk of developing not only myocardial infarction, but also restenosis of the reconstruction zone, as well as the associated ischemic stroke, which was demonstrated by our results.CONCLUSION: Patients with type 2 diabetes and a history of CEE are at increased risk of ischemic stroke at the hospital stage of observation and all unfavorable cardiovascular conditions (death, myocardial infarction, ischemic stroke, restenosis or ICA occlusion in the reconstruction zone) in the long-term postoperative period. |
| first_indexed | 2024-03-08T15:19:43Z |
| format | Article |
| id | doaj.art-de8c0cd986cb4082b42068fc663b286e |
| institution | Directory Open Access Journal |
| issn | 2072-0351 2072-0378 |
| language | English |
| last_indexed | 2025-03-14T16:35:34Z |
| publishDate | 2022-02-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Сахарный диабет |
| spelling | doaj.art-de8c0cd986cb4082b42068fc663b286e2025-02-21T09:29:37ZengEndocrinology Research CentreСахарный диабет2072-03512072-03782022-02-0124653654710.14341/DM1272210919Results of different kinds of carotid endarterectomy in patients with and without type 2 diabetes mellitusА. N. Kazantsev0R. A. Vinogradov1M. A. Chernyavsky2V. N. Kravchuk3D. V. Shmatov4A. A. Sorokin5A. A. Erofeev6V. A. Lutsenko7R. V. Sultanov8A. R. Shabaev9I. M. Radjabov10G. Sh. Bagdavadze11N. E. Zarkua12V. V. Matusevich13E. F. Vaiman14A. I. Solobuev15S. V. Artyukhov16R. Yu. Lider17V. A. Porkhanov18G. G. Khubulava19City Alexandrovskaya HospitalResearch Institute Regional Clinical Hospital No. 1 named. prof. S.V. Ochapovsky; Kuban State Medical UniversityNational Medical Research Center named after V.A. AlmazovMilitary Medical Academy named after SM Kirov; North-Western State Medical University named after I.I. MechnikovClinic of high medical technologies named after N.I. PirogovClinic of high medical technologies named after N.I. PirogovCity Multidisciplinary Hospital No. 2Kemerovo Regional Clinical Hospital named after S.V. BelyaevaKemerovo Regional Clinical Hospital named after S.V. BelyaevaKemerovo Regional Clinical Cardiological Dispensary named after acad. L.S. BarbarashMain Military Clinical Hospital named after acad. N.N.BurdenkoNorth-Western State Medical University named after I.I. MechnikovNorth-Western State Medical University named after I.I. MechnikovResearch Institute Regional Clinical Hospital No. 1 named. prof. S.V. OchapovskyKemerovo State Medical UniversityKemerovo State Medical UniversityCity Alexandrovskaya HospitalKemerovo State Medical UniversityResearch Institute Regional Clinical Hospital No. 1 named. prof. S.V. OchapovskyMilitary Medical Academy named after SM Kirov; First Saint Petersburg State Medical University named after I.I. acad. I.P. PavlovaBACKGROUND: Type 2 diabetes mellitus (DM) is one of the important markers for the development of adverse cardiovascular events after carotid endarterectomy (CEE). However, studies on this issue are based on small sample of patients and do not take into account the type of surgery as an additional factor of potentially negative impact on the course of the postoperative period.AIM: Analysis of hospital and long-term results of eversion and classical CEE with plastic surgery of the reconstruction zone with a biological patch in patients with type 2 diabetes and without it.MATERIALS AND METHODS: In this multicenter retrospective study from January 2010 to December 2020. included 5731 patients. Depending on the presence / absence of type 2 diabetes and the type of implemented CEE, 4 groups were formed: group 1 — 12.2% (n = 702) — patients with type 2 diabetes and eversion CEE; Group 2 — 55.0% (n = 3153) patients without type 2 diabetes and eversion CEE; Group 3 — 8.5% (n = 484) patients with type 2 diabetes and classical CEE; Group 4 — 24.3% (n = 1392) patients without type 2 diabetes and classical CEE. The duration of postoperative follow-up was 78.6 ± 39.2 months.RESULTS: At the long-term follow-up stage, patients with type 2 diabetes after the classical surgical technique demonstrated the highest rates of all types of complications: death (p <0.0001), MI (p = 0.011), ischemic stroke (p <0.0001), restenosis / occlusion of the ICA (p <0.0001), combined end point (p <0.0001). At the same time, the group of eversion CEE with impaired carbohydrate metabolism took the second position in terms of the prevalence of adverse events. These circumstances demonstrate that patch implantation is accompanied by an increased risk of developing not only myocardial infarction, but also restenosis of the reconstruction zone, as well as the associated ischemic stroke, which was demonstrated by our results.CONCLUSION: Patients with type 2 diabetes and a history of CEE are at increased risk of ischemic stroke at the hospital stage of observation and all unfavorable cardiovascular conditions (death, myocardial infarction, ischemic stroke, restenosis or ICA occlusion in the reconstruction zone) in the long-term postoperative period.https://www.dia-endojournals.ru/jour/article/view/12722carotid endarterectomydiabetes mellitusclassical carotid endarterectomyeversion carotid endarterectomyrestenosispatchbiological patch |
| spellingShingle | А. N. Kazantsev R. A. Vinogradov M. A. Chernyavsky V. N. Kravchuk D. V. Shmatov A. A. Sorokin A. A. Erofeev V. A. Lutsenko R. V. Sultanov A. R. Shabaev I. M. Radjabov G. Sh. Bagdavadze N. E. Zarkua V. V. Matusevich E. F. Vaiman A. I. Solobuev S. V. Artyukhov R. Yu. Lider V. A. Porkhanov G. G. Khubulava Results of different kinds of carotid endarterectomy in patients with and without type 2 diabetes mellitus Сахарный диабет carotid endarterectomy diabetes mellitus classical carotid endarterectomy eversion carotid endarterectomy restenosis patch biological patch |
| title | Results of different kinds of carotid endarterectomy in patients with and without type 2 diabetes mellitus |
| title_full | Results of different kinds of carotid endarterectomy in patients with and without type 2 diabetes mellitus |
| title_fullStr | Results of different kinds of carotid endarterectomy in patients with and without type 2 diabetes mellitus |
| title_full_unstemmed | Results of different kinds of carotid endarterectomy in patients with and without type 2 diabetes mellitus |
| title_short | Results of different kinds of carotid endarterectomy in patients with and without type 2 diabetes mellitus |
| title_sort | results of different kinds of carotid endarterectomy in patients with and without type 2 diabetes mellitus |
| topic | carotid endarterectomy diabetes mellitus classical carotid endarterectomy eversion carotid endarterectomy restenosis patch biological patch |
| url | https://www.dia-endojournals.ru/jour/article/view/12722 |
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