Effect of Ipsilateral, Contralateral or Bilateral Repetitive Transcranial Magnetic Stimulation in Patients with Lateralized Tinnitus: A Placebo-Controlled Randomized Study
The relative benefit of ipsilateral, contralateral, and bilateral repetitive transcranial magnetic stimulation (rTMS) for tinnitus treatment remains unclear, especially for patients with lateralized tinnitus. In this study, we compared outcomes after 10 sessions of 1-Hz rTMS at 110% of resting motor...
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MDPI AG
2022-06-01
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| Online Access: | https://www.mdpi.com/2076-3425/12/6/733 |
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| author | Yi Li Yong-Cong Shen John J. Galvin Ji-Sheng Liu Duo-Duo Tao |
| author_facet | Yi Li Yong-Cong Shen John J. Galvin Ji-Sheng Liu Duo-Duo Tao |
| author_sort | Yi Li |
| collection | DOAJ |
| description | The relative benefit of ipsilateral, contralateral, and bilateral repetitive transcranial magnetic stimulation (rTMS) for tinnitus treatment remains unclear, especially for patients with lateralized tinnitus. In this study, we compared outcomes after 10 sessions of 1-Hz rTMS at 110% of resting motor threshold over a two-week period. In total, 104 right-handed patients with lateralized subjective tinnitus were randomly divided into four groups according to rTMS treatment: Left (<i>n</i> = 29), Right (<i>n</i> = 23), Bilateral (<i>n</i> = 30), and Sham stimulation (<i>n</i> = 22). Outcomes included estimates of tinnitus severity, psychological state, and psychoacoustic measures. Patients with left- or right-sided tinnitus were similarly distributed across treatment groups. There were no significant changes in outcome measures for the Right or Sham treatment groups. For the Left and Bilateral groups, tinnitus severity was significantly lower after treatment (<i>p</i> < 0.05). The reduction in tinnitus severity was largest for ipsilateral treatment in the Left group. The overall response rate was 56.1% for the Left group, 46.7% for the Bilateral group, 8.3% for the Right group, and 8.3% for the Sham group. For the Left and Bilateral groups, the response rate was larger for patients with left- than right-sided tinnitus. Changes in tinnitus severity were best predicted by changes in anxiety, depression, and the loudness of the tinnitus. The results suggests that rTMS on the left temporoparietal cortex is more effective for patients with left-sided than with right-sided tinnitus. |
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| last_indexed | 2024-03-10T00:16:23Z |
| publishDate | 2022-06-01 |
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| spelling | doaj.art-de8c92e7cdcd4d359c71e6e0cd3701932023-11-23T15:50:33ZengMDPI AGBrain Sciences2076-34252022-06-0112673310.3390/brainsci12060733Effect of Ipsilateral, Contralateral or Bilateral Repetitive Transcranial Magnetic Stimulation in Patients with Lateralized Tinnitus: A Placebo-Controlled Randomized StudyYi Li0Yong-Cong Shen1John J. Galvin2Ji-Sheng Liu3Duo-Duo Tao4Department of Ear, Nose, and Throat, Dushu Lake Hospital Affiliated of Soochow University, Suzhou 215000, ChinaDepartment of Ear, Nose, and Throat, The First Affiliated of Soochow University, Suzhou 215000, ChinaHouse Institute Foundation, Los Angeles, CA 90057, USADepartment of Ear, Nose, and Throat, The First Affiliated of Soochow University, Suzhou 215000, ChinaDepartment of Ear, Nose, and Throat, Shaanxi Provincial People’s Hospital, Xi’an 710068, ChinaThe relative benefit of ipsilateral, contralateral, and bilateral repetitive transcranial magnetic stimulation (rTMS) for tinnitus treatment remains unclear, especially for patients with lateralized tinnitus. In this study, we compared outcomes after 10 sessions of 1-Hz rTMS at 110% of resting motor threshold over a two-week period. In total, 104 right-handed patients with lateralized subjective tinnitus were randomly divided into four groups according to rTMS treatment: Left (<i>n</i> = 29), Right (<i>n</i> = 23), Bilateral (<i>n</i> = 30), and Sham stimulation (<i>n</i> = 22). Outcomes included estimates of tinnitus severity, psychological state, and psychoacoustic measures. Patients with left- or right-sided tinnitus were similarly distributed across treatment groups. There were no significant changes in outcome measures for the Right or Sham treatment groups. For the Left and Bilateral groups, tinnitus severity was significantly lower after treatment (<i>p</i> < 0.05). The reduction in tinnitus severity was largest for ipsilateral treatment in the Left group. The overall response rate was 56.1% for the Left group, 46.7% for the Bilateral group, 8.3% for the Right group, and 8.3% for the Sham group. For the Left and Bilateral groups, the response rate was larger for patients with left- than right-sided tinnitus. Changes in tinnitus severity were best predicted by changes in anxiety, depression, and the loudness of the tinnitus. The results suggests that rTMS on the left temporoparietal cortex is more effective for patients with left-sided than with right-sided tinnitus.https://www.mdpi.com/2076-3425/12/6/733subjective tinnituslateralized tinnitusrepetitive transcranial magnetic stimulationvisual analogue scale |
| spellingShingle | Yi Li Yong-Cong Shen John J. Galvin Ji-Sheng Liu Duo-Duo Tao Effect of Ipsilateral, Contralateral or Bilateral Repetitive Transcranial Magnetic Stimulation in Patients with Lateralized Tinnitus: A Placebo-Controlled Randomized Study Brain Sciences subjective tinnitus lateralized tinnitus repetitive transcranial magnetic stimulation visual analogue scale |
| title | Effect of Ipsilateral, Contralateral or Bilateral Repetitive Transcranial Magnetic Stimulation in Patients with Lateralized Tinnitus: A Placebo-Controlled Randomized Study |
| title_full | Effect of Ipsilateral, Contralateral or Bilateral Repetitive Transcranial Magnetic Stimulation in Patients with Lateralized Tinnitus: A Placebo-Controlled Randomized Study |
| title_fullStr | Effect of Ipsilateral, Contralateral or Bilateral Repetitive Transcranial Magnetic Stimulation in Patients with Lateralized Tinnitus: A Placebo-Controlled Randomized Study |
| title_full_unstemmed | Effect of Ipsilateral, Contralateral or Bilateral Repetitive Transcranial Magnetic Stimulation in Patients with Lateralized Tinnitus: A Placebo-Controlled Randomized Study |
| title_short | Effect of Ipsilateral, Contralateral or Bilateral Repetitive Transcranial Magnetic Stimulation in Patients with Lateralized Tinnitus: A Placebo-Controlled Randomized Study |
| title_sort | effect of ipsilateral contralateral or bilateral repetitive transcranial magnetic stimulation in patients with lateralized tinnitus a placebo controlled randomized study |
| topic | subjective tinnitus lateralized tinnitus repetitive transcranial magnetic stimulation visual analogue scale |
| url | https://www.mdpi.com/2076-3425/12/6/733 |
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