Research progress on the mechanism of ferroptosis in ocular disease associated with retinal pigment epithelial cell injury
Ferroptosis is a newly identified programmed cell death characterized by lipid peroxidation and iron accumulation. In recent years, with the proposal of the concept of ferroptosis as well as the deepening of its mechanism research, great breakthroughs have been made in the exploration of the pathoge...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Press of International Journal of Ophthalmology (IJO PRESS)
2023-01-01
|
| Series: | Guoji Yanke Zazhi |
| Subjects: | |
| Online Access: | http://ies.ijo.cn/cn_publish/2023/1/202301015.pdf |
| _version_ | 1797962239954649088 |
|---|---|
| author | Qiao-Yun Wang Lai-Qing Xie |
| author_facet | Qiao-Yun Wang Lai-Qing Xie |
| author_sort | Qiao-Yun Wang |
| collection | DOAJ |
| description | Ferroptosis is a newly identified programmed cell death characterized by lipid peroxidation and iron accumulation. In recent years, with the proposal of the concept of ferroptosis as well as the deepening of its mechanism research, great breakthroughs have been made in the exploration of the pathogenesis of ocular diseases related to the function decline of retinal pigment epithelium cells(RPECs), such as age-related macular degeneration(AMD), retinitis pigmentosa(RP)and diabetic retinopathy(DR). This article reviews the basic concept of ferroptosis, the main mechanism of ferroptosis in RPECs and the role of ferroptosis regulation in the development of RPECs-related ocular diseases, hoping to provide references for the study of the pathogenesis of RPECs-related ocular diseases. |
| first_indexed | 2024-04-11T01:10:15Z |
| format | Article |
| id | doaj.art-de8d10ca745947b09d8b36675df8d492 |
| institution | Directory Open Access Journal |
| issn | 1672-5123 |
| language | English |
| last_indexed | 2024-04-11T01:10:15Z |
| publishDate | 2023-01-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | Guoji Yanke Zazhi |
| spelling | doaj.art-de8d10ca745947b09d8b36675df8d4922023-01-04T07:41:52ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51232023-01-01231757810.3980/j.issn.1672-5123.2023.1.15202301015Research progress on the mechanism of ferroptosis in ocular disease associated with retinal pigment epithelial cell injuryQiao-Yun Wang0Lai-Qing Xie1Department of Ophthalmology, the Second Affiliated Hospital of Soochow University, Suzhou 215004, Jiangsu Province, ChinaDepartment of Ophthalmology, the Second Affiliated Hospital of Soochow University, Suzhou 215004, Jiangsu Province, ChinaFerroptosis is a newly identified programmed cell death characterized by lipid peroxidation and iron accumulation. In recent years, with the proposal of the concept of ferroptosis as well as the deepening of its mechanism research, great breakthroughs have been made in the exploration of the pathogenesis of ocular diseases related to the function decline of retinal pigment epithelium cells(RPECs), such as age-related macular degeneration(AMD), retinitis pigmentosa(RP)and diabetic retinopathy(DR). This article reviews the basic concept of ferroptosis, the main mechanism of ferroptosis in RPECs and the role of ferroptosis regulation in the development of RPECs-related ocular diseases, hoping to provide references for the study of the pathogenesis of RPECs-related ocular diseases.http://ies.ijo.cn/cn_publish/2023/1/202301015.pdfferroptosisretinal pigment epithelial cellsocular disease |
| spellingShingle | Qiao-Yun Wang Lai-Qing Xie Research progress on the mechanism of ferroptosis in ocular disease associated with retinal pigment epithelial cell injury Guoji Yanke Zazhi ferroptosis retinal pigment epithelial cells ocular disease |
| title | Research progress on the mechanism of ferroptosis in ocular disease associated with retinal pigment epithelial cell injury |
| title_full | Research progress on the mechanism of ferroptosis in ocular disease associated with retinal pigment epithelial cell injury |
| title_fullStr | Research progress on the mechanism of ferroptosis in ocular disease associated with retinal pigment epithelial cell injury |
| title_full_unstemmed | Research progress on the mechanism of ferroptosis in ocular disease associated with retinal pigment epithelial cell injury |
| title_short | Research progress on the mechanism of ferroptosis in ocular disease associated with retinal pigment epithelial cell injury |
| title_sort | research progress on the mechanism of ferroptosis in ocular disease associated with retinal pigment epithelial cell injury |
| topic | ferroptosis retinal pigment epithelial cells ocular disease |
| url | http://ies.ijo.cn/cn_publish/2023/1/202301015.pdf |
| work_keys_str_mv | AT qiaoyunwang researchprogressonthemechanismofferroptosisinoculardiseaseassociatedwithretinalpigmentepithelialcellinjury AT laiqingxie researchprogressonthemechanismofferroptosisinoculardiseaseassociatedwithretinalpigmentepithelialcellinjury |