Long Non-Coding RNAs in Cardiac Remodeling
Cardiac remodeling occurs after stress to the heart, manifested as pathological processes, including hypertrophy and apoptosis of cardiomyocytes, dysfunction of vascular endothelial cells and vascular smooth muscle cells as well as differentiation and proliferation of fibroblasts, ultimately resulti...
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| Format: | Article |
| Language: | English |
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Cell Physiol Biochem Press GmbH & Co KG
2017-04-01
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| Series: | Cellular Physiology and Biochemistry |
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| Online Access: | http://www.karger.com/Article/FullText/471913 |
| _version_ | 1818450793239412736 |
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| author | Shutong Shen Huimin Jiang Yihua Bei Junjie Xiao Xinli Li |
| author_facet | Shutong Shen Huimin Jiang Yihua Bei Junjie Xiao Xinli Li |
| author_sort | Shutong Shen |
| collection | DOAJ |
| description | Cardiac remodeling occurs after stress to the heart, manifested as pathological processes, including hypertrophy and apoptosis of cardiomyocytes, dysfunction of vascular endothelial cells and vascular smooth muscle cells as well as differentiation and proliferation of fibroblasts, ultimately resulting in progression of cardiovascular diseases. Emerging evidence has revealed that long non-coding RNAs (lncRNAs) acted as powerful and dynamic modifiers of cardiac remodeling. LncRNAs including Chaer, Chast, Mhrt, CHRF, ROR, H19, and MIAT have been implicated in cardiac hypertrophy while NRF, H19, APF, CARL, UCA, Mhrt and several other lncRNAs (n379599, n379519, n384640, n380433 and n410105) in cardiomyocyte loss and extracellular matrix remodeling. In addition, MALAT1 and TGFB2-OT1 have been reported to contribute to vascular endothelial cells dysfunction while lincRNA-p21 and lnc-Ang362 to vascular smooth muscle cells proliferation. Thus, manipulation of lncRNA expression levels through either the inhibition of disease-up-regulated lncRNAs or increasing disease-down-regulated lncRNAs represents novel therapeutic strategies for cardiac remodeling. |
| first_indexed | 2024-12-14T20:56:57Z |
| format | Article |
| id | doaj.art-de8d441c430d45f9a78a05ffa688eede |
| institution | Directory Open Access Journal |
| issn | 1015-8987 1421-9778 |
| language | English |
| last_indexed | 2024-12-14T20:56:57Z |
| publishDate | 2017-04-01 |
| publisher | Cell Physiol Biochem Press GmbH & Co KG |
| record_format | Article |
| series | Cellular Physiology and Biochemistry |
| spelling | doaj.art-de8d441c430d45f9a78a05ffa688eede2022-12-21T22:47:41ZengCell Physiol Biochem Press GmbH & Co KGCellular Physiology and Biochemistry1015-89871421-97782017-04-014151830183710.1159/000471913471913Long Non-Coding RNAs in Cardiac RemodelingShutong ShenHuimin JiangYihua BeiJunjie XiaoXinli LiCardiac remodeling occurs after stress to the heart, manifested as pathological processes, including hypertrophy and apoptosis of cardiomyocytes, dysfunction of vascular endothelial cells and vascular smooth muscle cells as well as differentiation and proliferation of fibroblasts, ultimately resulting in progression of cardiovascular diseases. Emerging evidence has revealed that long non-coding RNAs (lncRNAs) acted as powerful and dynamic modifiers of cardiac remodeling. LncRNAs including Chaer, Chast, Mhrt, CHRF, ROR, H19, and MIAT have been implicated in cardiac hypertrophy while NRF, H19, APF, CARL, UCA, Mhrt and several other lncRNAs (n379599, n379519, n384640, n380433 and n410105) in cardiomyocyte loss and extracellular matrix remodeling. In addition, MALAT1 and TGFB2-OT1 have been reported to contribute to vascular endothelial cells dysfunction while lincRNA-p21 and lnc-Ang362 to vascular smooth muscle cells proliferation. Thus, manipulation of lncRNA expression levels through either the inhibition of disease-up-regulated lncRNAs or increasing disease-down-regulated lncRNAs represents novel therapeutic strategies for cardiac remodeling.http://www.karger.com/Article/FullText/471913Long non-coding RNAsCardiac remodelingHypertrophyApoptosis |
| spellingShingle | Shutong Shen Huimin Jiang Yihua Bei Junjie Xiao Xinli Li Long Non-Coding RNAs in Cardiac Remodeling Cellular Physiology and Biochemistry Long non-coding RNAs Cardiac remodeling Hypertrophy Apoptosis |
| title | Long Non-Coding RNAs in Cardiac Remodeling |
| title_full | Long Non-Coding RNAs in Cardiac Remodeling |
| title_fullStr | Long Non-Coding RNAs in Cardiac Remodeling |
| title_full_unstemmed | Long Non-Coding RNAs in Cardiac Remodeling |
| title_short | Long Non-Coding RNAs in Cardiac Remodeling |
| title_sort | long non coding rnas in cardiac remodeling |
| topic | Long non-coding RNAs Cardiac remodeling Hypertrophy Apoptosis |
| url | http://www.karger.com/Article/FullText/471913 |
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