Progress and perspectives on the role of RPE cell inflammatory responses in the development of age-related macular degeneration
Suofu Qin, Gerard A RodriguesRetinal Disease Research, Department of Biological Sciences, Allergan, Inc., Irvine, CA, USAAbstract: Age-related macular degeneration (AMD) is the leading cause of blindness in developed countries. The etiology of AMD remains poorly understood and no treatment is curren...
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| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2008-12-01
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| Series: | Journal of Inflammation Research |
| Online Access: | http://www.dovepress.com/progress-and-perspectives-on-the-role-of-rpe-cell-inflammatory-respons-a2661 |
| _version_ | 1818407692466651136 |
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| author | Suofu Qin Gerard A Rodrigues |
| author_facet | Suofu Qin Gerard A Rodrigues |
| author_sort | Suofu Qin |
| collection | DOAJ |
| description | Suofu Qin, Gerard A RodriguesRetinal Disease Research, Department of Biological Sciences, Allergan, Inc., Irvine, CA, USAAbstract: Age-related macular degeneration (AMD) is the leading cause of blindness in developed countries. The etiology of AMD remains poorly understood and no treatment is currently available for the atrophic form of AMD. Atrophic AMD has been proposed to involve abnormalities of the retinal pigment epithelium (RPE), which lies beneath the photoreceptor cells and normally provides critical metabolic support to these light-sensing cells. Cumulative oxidative stress and local inflammation are thought to represent pathological processes involved in the etiology of atrophic AMD. Studies of tissue culture and animal models reveal that oxidative stress-induced injury to the RPE results in a chronic inflammatory response, drusen formation, and RPE atrophy. RPE degeneration in turn causes a progressive degeneration of photoreceptors, leading to the irreversible loss of vision. This review describes some of the potential major molecular and cellular events contributing to RPE death and inflammatory responses. In addition, potential target areas for therapeutic intervention will be discussed and new experimental therapeutic strategies for atrophic AMD will be presented.Keywords: age-related macular degeneration, danger signals, complement, inflammation, retinal pigment epithelial cells |
| first_indexed | 2024-12-14T09:31:53Z |
| format | Article |
| id | doaj.art-de8d80e301fe4178ae6576414fd17ccf |
| institution | Directory Open Access Journal |
| issn | 1178-7031 |
| language | English |
| last_indexed | 2024-12-14T09:31:53Z |
| publishDate | 2008-12-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Inflammation Research |
| spelling | doaj.art-de8d80e301fe4178ae6576414fd17ccf2022-12-21T23:08:03ZengDove Medical PressJournal of Inflammation Research1178-70312008-12-012008default4965Progress and perspectives on the role of RPE cell inflammatory responses in the development of age-related macular degenerationSuofu QinGerard A RodriguesSuofu Qin, Gerard A RodriguesRetinal Disease Research, Department of Biological Sciences, Allergan, Inc., Irvine, CA, USAAbstract: Age-related macular degeneration (AMD) is the leading cause of blindness in developed countries. The etiology of AMD remains poorly understood and no treatment is currently available for the atrophic form of AMD. Atrophic AMD has been proposed to involve abnormalities of the retinal pigment epithelium (RPE), which lies beneath the photoreceptor cells and normally provides critical metabolic support to these light-sensing cells. Cumulative oxidative stress and local inflammation are thought to represent pathological processes involved in the etiology of atrophic AMD. Studies of tissue culture and animal models reveal that oxidative stress-induced injury to the RPE results in a chronic inflammatory response, drusen formation, and RPE atrophy. RPE degeneration in turn causes a progressive degeneration of photoreceptors, leading to the irreversible loss of vision. This review describes some of the potential major molecular and cellular events contributing to RPE death and inflammatory responses. In addition, potential target areas for therapeutic intervention will be discussed and new experimental therapeutic strategies for atrophic AMD will be presented.Keywords: age-related macular degeneration, danger signals, complement, inflammation, retinal pigment epithelial cellshttp://www.dovepress.com/progress-and-perspectives-on-the-role-of-rpe-cell-inflammatory-respons-a2661 |
| spellingShingle | Suofu Qin Gerard A Rodrigues Progress and perspectives on the role of RPE cell inflammatory responses in the development of age-related macular degeneration Journal of Inflammation Research |
| title | Progress and perspectives on the role of RPE cell inflammatory responses in the development of age-related macular degeneration |
| title_full | Progress and perspectives on the role of RPE cell inflammatory responses in the development of age-related macular degeneration |
| title_fullStr | Progress and perspectives on the role of RPE cell inflammatory responses in the development of age-related macular degeneration |
| title_full_unstemmed | Progress and perspectives on the role of RPE cell inflammatory responses in the development of age-related macular degeneration |
| title_short | Progress and perspectives on the role of RPE cell inflammatory responses in the development of age-related macular degeneration |
| title_sort | progress and perspectives on the role of rpe cell inflammatory responses in the development of age related macular degeneration |
| url | http://www.dovepress.com/progress-and-perspectives-on-the-role-of-rpe-cell-inflammatory-respons-a2661 |
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