Effects of Fucoxanthin on the Inhibition of Dexamethasone-Induced Skeletal Muscle Loss in Mice
Fucoxanthin (Fx) has preventive effect against muscle atrophy and myotube loss in vitro, but it has not yet been examined in vivo. Therefore, we aimed to investigate the effect of Fx on dexamethasone (Dex)-induced muscle atrophy and fat mass in mice. ICR mice were fed with Fx diets from 2 weeks befo...
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MDPI AG
2021-03-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/4/1079 |
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| author | Maki Yoshikawa Masashi Hosokawa Kazuo Miyashita Hoyoku Nishino Takeshi Hashimoto |
| author_facet | Maki Yoshikawa Masashi Hosokawa Kazuo Miyashita Hoyoku Nishino Takeshi Hashimoto |
| author_sort | Maki Yoshikawa |
| collection | DOAJ |
| description | Fucoxanthin (Fx) has preventive effect against muscle atrophy and myotube loss in vitro, but it has not yet been examined in vivo. Therefore, we aimed to investigate the effect of Fx on dexamethasone (Dex)-induced muscle atrophy and fat mass in mice. ICR mice were fed with Fx diets from 2 weeks before Dex treatment to the end of the study. Muscle atrophy was induced in the mice by oral administration of Dex. Body weight was significantly lower by Dex treatment. Visceral fat mass in the Fx-treated group were significantly lower than those in the control group. The Dex-induced decrease in tibialis anterior muscle mass was ameliorated by Fx treatment. Fx treatment significantly attenuated muscle lipid peroxidation compared with the control and Dex-treated groups. The phosphorylation of AMPK was significantly higher in the Dex-treated group than in the control group. The expression of cytochrome c oxidase (COX) IV was significantly higher in the Fx-treated group than in the control group. These results suggest that Fx may be a beneficial material to prevent muscle atrophy in vivo, in addition to the effect of fat loss. |
| first_indexed | 2024-03-10T12:53:41Z |
| format | Article |
| id | doaj.art-de8f5e6a4d0047ae9da90a955ec7a9fe |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T12:53:41Z |
| publishDate | 2021-03-01 |
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| series | Nutrients |
| spelling | doaj.art-de8f5e6a4d0047ae9da90a955ec7a9fe2023-11-21T12:05:38ZengMDPI AGNutrients2072-66432021-03-01134107910.3390/nu13041079Effects of Fucoxanthin on the Inhibition of Dexamethasone-Induced Skeletal Muscle Loss in MiceMaki Yoshikawa0Masashi Hosokawa1Kazuo Miyashita2Hoyoku Nishino3Takeshi Hashimoto4Faculty of Sport and Health Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu 525-8577, JapanFaculty of Fisheries Sciences, Hokkaido University, 3-1-1, Minato-cho, Hakodate 041-8611, JapanFaculty of Fisheries Sciences, Hokkaido University, 3-1-1, Minato-cho, Hakodate 041-8611, JapanKyoto Prefecture University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, JapanFaculty of Sport and Health Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu 525-8577, JapanFucoxanthin (Fx) has preventive effect against muscle atrophy and myotube loss in vitro, but it has not yet been examined in vivo. Therefore, we aimed to investigate the effect of Fx on dexamethasone (Dex)-induced muscle atrophy and fat mass in mice. ICR mice were fed with Fx diets from 2 weeks before Dex treatment to the end of the study. Muscle atrophy was induced in the mice by oral administration of Dex. Body weight was significantly lower by Dex treatment. Visceral fat mass in the Fx-treated group were significantly lower than those in the control group. The Dex-induced decrease in tibialis anterior muscle mass was ameliorated by Fx treatment. Fx treatment significantly attenuated muscle lipid peroxidation compared with the control and Dex-treated groups. The phosphorylation of AMPK was significantly higher in the Dex-treated group than in the control group. The expression of cytochrome c oxidase (COX) IV was significantly higher in the Fx-treated group than in the control group. These results suggest that Fx may be a beneficial material to prevent muscle atrophy in vivo, in addition to the effect of fat loss.https://www.mdpi.com/2072-6643/13/4/1079carotenoidantioxidantsarcopenic obesity |
| spellingShingle | Maki Yoshikawa Masashi Hosokawa Kazuo Miyashita Hoyoku Nishino Takeshi Hashimoto Effects of Fucoxanthin on the Inhibition of Dexamethasone-Induced Skeletal Muscle Loss in Mice Nutrients carotenoid antioxidant sarcopenic obesity |
| title | Effects of Fucoxanthin on the Inhibition of Dexamethasone-Induced Skeletal Muscle Loss in Mice |
| title_full | Effects of Fucoxanthin on the Inhibition of Dexamethasone-Induced Skeletal Muscle Loss in Mice |
| title_fullStr | Effects of Fucoxanthin on the Inhibition of Dexamethasone-Induced Skeletal Muscle Loss in Mice |
| title_full_unstemmed | Effects of Fucoxanthin on the Inhibition of Dexamethasone-Induced Skeletal Muscle Loss in Mice |
| title_short | Effects of Fucoxanthin on the Inhibition of Dexamethasone-Induced Skeletal Muscle Loss in Mice |
| title_sort | effects of fucoxanthin on the inhibition of dexamethasone induced skeletal muscle loss in mice |
| topic | carotenoid antioxidant sarcopenic obesity |
| url | https://www.mdpi.com/2072-6643/13/4/1079 |
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