An outbreak of locally acquired Plasmodium vivax malaria among migrant workers in Oman
Plasmodium vivax is the most widely distributed human malaria parasite. Outside sub-Saharan Africa, the proportion of P. vivax malaria is rising. A major cause for concern is the re-emergence of Plasmodium vivax in malaria-free areas. Oman, situated in the south-eastern corner of the Arabian Peninsu...
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| Format: | Article |
| Language: | English |
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EDP Sciences
2017-01-01
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| Series: | Parasite |
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| Online Access: | https://doi.org/10.1051/parasite/2017028 |
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| author | Simon Bruno Sow Fatimata Al Mukhaini Said K. Al-Abri Seif Ali Osama A.M. Bonnot Guillaume Bienvenu Anne-Lise Petersen Eskild Picot Stéphane |
| author_facet | Simon Bruno Sow Fatimata Al Mukhaini Said K. Al-Abri Seif Ali Osama A.M. Bonnot Guillaume Bienvenu Anne-Lise Petersen Eskild Picot Stéphane |
| author_sort | Simon Bruno |
| collection | DOAJ |
| description | Plasmodium vivax is the most widely distributed human malaria parasite. Outside sub-Saharan Africa, the proportion of P. vivax malaria is rising. A major cause for concern is the re-emergence of Plasmodium vivax in malaria-free areas. Oman, situated in the south-eastern corner of the Arabian Peninsula, has long been an area of vivax malaria transmission but no locally acquired cases were reported in 2004. However, local transmission has been registered in small outbreaks since 2007. In this study, a local outbreak of 54 cases over 50 days in 2014 was analyzed retrospectively and stained blood slides have been obtained for parasite identification and genotyping. The aim of this study was to identify the geographical origin of these cases, in an attempt to differentiate between imported cases and local transmission. Using circumsporozoite protein (csp), merozoite surface protein 1 (msp1), and merozoite surface protein 3 (msp3) markers for genotyping of parasite DNA obtained by scrapping off the surface of smears, genetic diversity and phylogenetic analysis were performed. The study found that the samples had very low genetic diversity, a temperate genotype, and a high genetic distance, with most of the reference strains coming from endemic countries. We conclude that a small outbreak of imported malaria is not associated with re-emergence of malaria transmission in Oman, as no new cases have been seen since the outbreak ended. |
| first_indexed | 2024-03-11T14:09:38Z |
| format | Article |
| id | doaj.art-de911b576a164bf099c36389821cc2d0 |
| institution | Directory Open Access Journal |
| issn | 1776-1042 |
| language | English |
| last_indexed | 2024-03-11T14:09:38Z |
| publishDate | 2017-01-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | Parasite |
| spelling | doaj.art-de911b576a164bf099c36389821cc2d02023-11-02T00:41:42ZengEDP SciencesParasite1776-10422017-01-01242510.1051/parasite/2017028parasite170039An outbreak of locally acquired Plasmodium vivax malaria among migrant workers in OmanSimon BrunoSow FatimataAl Mukhaini Said K.Al-Abri SeifAli Osama A.M.Bonnot GuillaumeBienvenu Anne-LisePetersen EskildPicot StéphanePlasmodium vivax is the most widely distributed human malaria parasite. Outside sub-Saharan Africa, the proportion of P. vivax malaria is rising. A major cause for concern is the re-emergence of Plasmodium vivax in malaria-free areas. Oman, situated in the south-eastern corner of the Arabian Peninsula, has long been an area of vivax malaria transmission but no locally acquired cases were reported in 2004. However, local transmission has been registered in small outbreaks since 2007. In this study, a local outbreak of 54 cases over 50 days in 2014 was analyzed retrospectively and stained blood slides have been obtained for parasite identification and genotyping. The aim of this study was to identify the geographical origin of these cases, in an attempt to differentiate between imported cases and local transmission. Using circumsporozoite protein (csp), merozoite surface protein 1 (msp1), and merozoite surface protein 3 (msp3) markers for genotyping of parasite DNA obtained by scrapping off the surface of smears, genetic diversity and phylogenetic analysis were performed. The study found that the samples had very low genetic diversity, a temperate genotype, and a high genetic distance, with most of the reference strains coming from endemic countries. We conclude that a small outbreak of imported malaria is not associated with re-emergence of malaria transmission in Oman, as no new cases have been seen since the outbreak ended.https://doi.org/10.1051/parasite/2017028MalariaPlasmodium vivaxOutbreakOmanGenotypingTemperate genotype |
| spellingShingle | Simon Bruno Sow Fatimata Al Mukhaini Said K. Al-Abri Seif Ali Osama A.M. Bonnot Guillaume Bienvenu Anne-Lise Petersen Eskild Picot Stéphane An outbreak of locally acquired Plasmodium vivax malaria among migrant workers in Oman Parasite Malaria Plasmodium vivax Outbreak Oman Genotyping Temperate genotype |
| title | An outbreak of locally acquired Plasmodium vivax malaria among migrant workers in Oman |
| title_full | An outbreak of locally acquired Plasmodium vivax malaria among migrant workers in Oman |
| title_fullStr | An outbreak of locally acquired Plasmodium vivax malaria among migrant workers in Oman |
| title_full_unstemmed | An outbreak of locally acquired Plasmodium vivax malaria among migrant workers in Oman |
| title_short | An outbreak of locally acquired Plasmodium vivax malaria among migrant workers in Oman |
| title_sort | outbreak of locally acquired plasmodium vivax malaria among migrant workers in oman |
| topic | Malaria Plasmodium vivax Outbreak Oman Genotyping Temperate genotype |
| url | https://doi.org/10.1051/parasite/2017028 |
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