Fine needle aspiration cytology of thyroid and its correlation with serological findings
<p><strong>Background: </strong>Thyroid autoimmunity can cause several forms of thyroid disorders i.e. Grave’s disease, Hashimoto’s thyroiditis, atrophic autoimmune thyroiditis, post-partum thyroidits etc. Cytological diagnosis may be sometimes difficult is some cases. In such cond...
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| Format: | Article |
| Language: | English |
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Association of Clinical Pathologists of Nepal
2017-03-01
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| Series: | Journal of Pathology of Nepal |
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| Online Access: | http://www.nepjol.info/index.php/JPN/article/view/16777 |
| _version_ | 1818215675831779328 |
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| author | S Karki A Shrestha |
| author_facet | S Karki A Shrestha |
| author_sort | S Karki |
| collection | DOAJ |
| description | <p><strong>Background: </strong>Thyroid autoimmunity can cause several forms of thyroid disorders i.e. Grave’s disease, Hashimoto’s thyroiditis, atrophic autoimmune thyroiditis, post-partum thyroidits etc. Cytological diagnosis may be sometimes difficult is some cases. In such conditions, cytology along with serological tests aid at reaching a correct diagnosis.Hence, this study was undertaken to evaluate the serum level of anti-TPO antibody with respect to serum concentrations of thyroid hormones and its importance in diagnosing autoimmune thyroiditis.</p><p><strong>Material and Methods:</strong> This study was carried out in the department of pathology from June 2013-May 2014. Patients coming to the department of pathology TUTH, Maharajgunj for FNA of thyroid were included. TFT level was noted and anti TPO antibody level was evaluated by CLIA.</p><p><strong>Results:</strong> Ninety-five thyroid FNAC was included in the study, which comprises of 16.8 % males and 83.2% females with a M: F 1: 4.9. Maximum number of cases was seen in the age range 21-30 years (25.3%), mean age being 40.4years. The cytological diagnosis comprised colloid goiter(43.2%), lymphocytic thyroiditis (25.3%), Hashimoto thyroiditis(18.9%). Out of 42 cases of autoimmune thyroiditis diagnosed cytologically, 16 (38%) were hypothyroid, 4 (9.5%) hyperthyroid, 8 (19%) sub-clinical hypothyroid and 14 (33.5%) were euthyroid. The sensitivity and specificity of positive anti TPO in correctly identifying autoimmune thyroiditis was 85.7% and 79.2% respectively. The positive and negative predictive value for the test was 76.5% and 87.5% respectively.</p><p><strong>Conclusion: </strong>Nodular goitre can harbour a certain per cent of autoimmune thyroiditis and in such cases anti TPO antibody level along with cytodiagnosis appears to be helpful.</p> |
| first_indexed | 2024-12-12T06:39:51Z |
| format | Article |
| id | doaj.art-de93b0ed57c2476f9a2522c2fecb9cff |
| institution | Directory Open Access Journal |
| issn | 2091-0797 2091-0908 |
| language | English |
| last_indexed | 2024-12-12T06:39:51Z |
| publishDate | 2017-03-01 |
| publisher | Association of Clinical Pathologists of Nepal |
| record_format | Article |
| series | Journal of Pathology of Nepal |
| spelling | doaj.art-de93b0ed57c2476f9a2522c2fecb9cff2022-12-22T00:34:22ZengAssociation of Clinical Pathologists of NepalJournal of Pathology of Nepal2091-07972091-09082017-03-01711054105810.3126/jpn.v7i1.1677713022Fine needle aspiration cytology of thyroid and its correlation with serological findingsS Karki0A Shrestha1Tribhuvan University Teaching Hospital, MaharjagunjTribhuvan University Teaching Hospital, Maharjagunj<p><strong>Background: </strong>Thyroid autoimmunity can cause several forms of thyroid disorders i.e. Grave’s disease, Hashimoto’s thyroiditis, atrophic autoimmune thyroiditis, post-partum thyroidits etc. Cytological diagnosis may be sometimes difficult is some cases. In such conditions, cytology along with serological tests aid at reaching a correct diagnosis.Hence, this study was undertaken to evaluate the serum level of anti-TPO antibody with respect to serum concentrations of thyroid hormones and its importance in diagnosing autoimmune thyroiditis.</p><p><strong>Material and Methods:</strong> This study was carried out in the department of pathology from June 2013-May 2014. Patients coming to the department of pathology TUTH, Maharajgunj for FNA of thyroid were included. TFT level was noted and anti TPO antibody level was evaluated by CLIA.</p><p><strong>Results:</strong> Ninety-five thyroid FNAC was included in the study, which comprises of 16.8 % males and 83.2% females with a M: F 1: 4.9. Maximum number of cases was seen in the age range 21-30 years (25.3%), mean age being 40.4years. The cytological diagnosis comprised colloid goiter(43.2%), lymphocytic thyroiditis (25.3%), Hashimoto thyroiditis(18.9%). Out of 42 cases of autoimmune thyroiditis diagnosed cytologically, 16 (38%) were hypothyroid, 4 (9.5%) hyperthyroid, 8 (19%) sub-clinical hypothyroid and 14 (33.5%) were euthyroid. The sensitivity and specificity of positive anti TPO in correctly identifying autoimmune thyroiditis was 85.7% and 79.2% respectively. The positive and negative predictive value for the test was 76.5% and 87.5% respectively.</p><p><strong>Conclusion: </strong>Nodular goitre can harbour a certain per cent of autoimmune thyroiditis and in such cases anti TPO antibody level along with cytodiagnosis appears to be helpful.</p>http://www.nepjol.info/index.php/JPN/article/view/16777AutoimmuneAnti-peroxidase antibodygoitreHasimoto’sthyroiditis |
| spellingShingle | S Karki A Shrestha Fine needle aspiration cytology of thyroid and its correlation with serological findings Journal of Pathology of Nepal Autoimmune Anti-peroxidase antibody goitre Hasimoto’s thyroiditis |
| title | Fine needle aspiration cytology of thyroid and its correlation with serological findings |
| title_full | Fine needle aspiration cytology of thyroid and its correlation with serological findings |
| title_fullStr | Fine needle aspiration cytology of thyroid and its correlation with serological findings |
| title_full_unstemmed | Fine needle aspiration cytology of thyroid and its correlation with serological findings |
| title_short | Fine needle aspiration cytology of thyroid and its correlation with serological findings |
| title_sort | fine needle aspiration cytology of thyroid and its correlation with serological findings |
| topic | Autoimmune Anti-peroxidase antibody goitre Hasimoto’s thyroiditis |
| url | http://www.nepjol.info/index.php/JPN/article/view/16777 |
| work_keys_str_mv | AT skarki fineneedleaspirationcytologyofthyroidanditscorrelationwithserologicalfindings AT ashrestha fineneedleaspirationcytologyofthyroidanditscorrelationwithserologicalfindings |